Outcome of esophageal atresia in Germany

2020 ◽  
Author(s):  
A Schmedding ◽  
B Wittekindt ◽  
R Schloesser ◽  
M Hutter ◽  
U Rolle
Keyword(s):  
Mortality Rate ◽  
Esophageal Atresia ◽  
First Year ◽  
Insurance Company ◽  
Associated Anomalies ◽  
Clinical Registry ◽  
Major Health ◽  
First Year Of Life ◽  
Overall Mortality

Abstract The aim of this study was to evaluate the outcome of esophageal atresia in Germany in a retrospective observational study of a large cohort. Data from the major health insurance company in Germany, which covers approximately 30% of German patients, were analyzed. All patients born and registered between 2009 and 2013 with a diagnosis of esophageal atresia at first admission to the hospital were included. Mortality was analyzed during the first year of life. We identified 287 patients with esophageal atresia, including 253 with and 34 without tracheoesophageal fistula. Associated anomalies were found in 53.7% of the patients; the most frequent were cardiac anomalies (41.8%), anomalies of the urinary tract (17.4%), and atresia of the colon, rectum, and anus (9.4%). Forty-one patients (14.3%) had a birth weight <1500 g. Seventeen patients (5.9%) died before surgery. Gastrostomy was performed during the index admission in 70 patients (25.9%). The reconstruction of the esophageal passage was performed in 247 patients (93.9%). Forty-eight percent of the patients who underwent an operation required dilatation. The mortality rate in the patients who underwent an operation was 10.4%. These results from Germany correspond to the international results that have been reported. The number of dilatations was in the middle of the range of those reported in the literature; the overall mortality rate was in the upper portion of the range of the international rates. Efforts should be made to establish a clinical registry to measure and improve the quality of care for this and other rare conditions.

DOZ047.22: FEED-EASY: feeding disorders in children with esophageal atresia study

2019 ◽  
Vol 32 (Supplement_1) ◽  
Author(s):  
A Pham ◽  
E Dugelay ◽  
A Bonnard ◽  
T Gelas ◽  
V Rousseau ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Esophageal Atresia ◽  
Anastomotic Stricture ◽  
Primary Anastomosis ◽  
Feeding Disorders ◽  
First Year ◽  
Aversive Events ◽  
French Study ◽  
First Year Of Life

Abstract Introduction With advances in surgical and neonatal care, survival of patients with esophageal atresia (EA) has improved over time. While a number of conditions associated with EA may have an impact on feeding development (delayed primary anastomosis, anastomotic leaks, recurrent tracheoesophageal fistula, anastomotic stricture, gastroesophageal reflux, esophageal dysmotility, etc.) and although children with EA experience a number of oral aversive events in their first year of life, feeding disorders (FD) are poorly described and frequently unrecognized. The primary aim of this study was to describe FD in children born with EA, with a standardized scale. The secondary aim was to describe conditions associated with FD. Methods FEED-EASY is a multicentric French study. Parents of children born with EA between 2013 and 2016 in one of the 22 participating centers were asked to participate and received the French version of the standardized and reproductive ‘Montreal Children's Hospital Feeding Scale (MCH-FS)’. Results One hundred and forty-five children were included; 61 (42%) had FD according to the MCH-FS. These children were characterized by disinterest in food, oral hypersensitivity, difficulty in touching some textures and food avoidance, with an influence in quality of life. Nineteen (13%) were tube-fed between 1 and 4 years of age. Birth weight and chronic respiratory difficulties were associated with FD in children with EA. Anastomotic stricture (present in 31% of the included children) was not associated with FD. Conclusions FD is frequent and unrecognized in children with EA, and can influence growth and quality of life. MCH-FS allows pediatricians to identify FD in children with EA within a couple of minutes.

scholarly journals ALCAPA: The Al Capone of coronary artery anomalies

2012 ◽  
Vol 16 (3) ◽  
pp. 100-101 ◽  
Author(s):  
Farzanah Ismail
Keyword(s):  
Coronary Artery ◽  
Mortality Rate ◽  
Left Coronary Artery ◽  
First Year ◽  
Coronary Artery Anomalies ◽  
Perfusion System ◽  
Anomalous Left Coronary Artery ◽  
First Year Of Life ◽  
Anomalous Left Coronary ◽  
Artery Perfusion

Anomalous left coronary artery originating from the pulmonary artery (ALCAPA) is a rare coronary artery anomaly that presents with myocardial ischaemia or infarction and/or cardiac failure in infants. It is associated with a mortality rate of 90% within the first year of life. Surgical correction to re-establish a two-coronary artery perfusion system is the treatment of choice, once patients are medically stable.

scholarly journals ANÁLISIS DEL CRECIMIENTO Y LA MORTALIDAD DE ANISOTREMUS INTERRUPTUS (GILL) (PERCIFORMES: HAEMULIDAE) EN LA COSTA DE COLIMA, MÉXICO

2016 ◽  
Vol 33 ◽  
Author(s):  
Elaine Espino Barr ◽  
Manuel Gallardo Cabello ◽  
Fernando González Orozco ◽  
Arturo Garcia Boa
Keyword(s):  
Mortality Rate ◽  
Growth Parameters ◽  
Total Mortality ◽  
Condition Index ◽  
First Year ◽  
The Third ◽  
Second Year ◽  
First Year Of Life ◽  
Mortality Analysis

This paper deals with the growth and mortality analysis of the burrito grunt A n i s o t remus interru p t u s on the coast of Colima, México. The estimated growth parameters are: L¥ = 50.59 cm; W¥ = 5,051.04 g; k = 0.147 years- 1; to = -0.916 years; A0 . 9 5 = 19.46 years. Most of the growth occurred during the first year of life, when the grunt grows 12.52 cm, the second year it grows 4.95 cm and the third, 4.60 cm. The highest value of the condition index took place between February and September. The total mortality rate (Z) was calculated as 0.53 years- 1. These values are basic for the plan of administration of the fishery of this species.

scholarly journals Valuing Health Status in the First Year of Life: The Infant Health-Related Quality of Life Instrument

2019 ◽  
Vol 22 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Ruslan Jabrayilov ◽  
Karin M. Vermeulen ◽  
Patrick Detzel ◽  
Livia Dainelli ◽  
Antoinette D.I. van Asselt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Infant Health ◽  
First Year ◽  
Health Related Quality ◽  
Life Instrument ◽  
Related Quality ◽  
Health Related ◽  
First Year Of Life

Asthma-like symptoms in the first year of life and health-related quality of life at age 12 months: the Generation R study

2011 ◽  
Vol 21 (3) ◽  
pp. 545-554 ◽  
Author(s):  
Ashna D. Mohangoo ◽  
Harry J. de Koning ◽  
Johan C. de Jongste ◽  
Jeanne M. Landgraf ◽  
Johannes C. van der Wouden ◽  
...  
Keyword(s):  
Quality Of Life ◽  
First Year ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
First Year Of Life

Neurodevelopmental outcome in infants with esophageal atresia: risk factors in the first year of life

2020 ◽  
Author(s):  
Bevilacqua Francesca ◽  
Ragni Benedetta ◽  
Conforti Andrea ◽  
Braguglia Annabella ◽  
Gentile Simonetta ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Cognitive Development ◽  
Low Birth Weight ◽  
Multiple Regression ◽  
Esophageal Atresia ◽  
Gestational Age ◽  
Motor Development ◽  
First Year ◽  
First Year Of Life

Summary Data on neurodevelopmental outcomes of infants born with esophageal atresia (EA) are still scarce and controversial. The aims of our study were to evaluate motor and cognitive development during the first year of life, in patients operated on of EA and to investigate potential risk factors for motor and cognitive development both at 6 and 12 months. This is an observational prospective longitudinal study in a selected cohort of type C and D EA infants enrolled in our follow-up program from 2009 to 2017. In order to exclude possible confounding factors, the following exclusion criteria were applied: (i) gestational age ≤ 32 weeks and/or birth weight ≤ 1500 g; (ii) genetic syndrome or chromosomal anomaly known to be associated with neurodevelopmental delay; (iii) neurologic disease; (iv) esophageal gap ≥three vertebral bodies. Patients were evaluated at 6 and 12 months of life (corrected age for infants with a gestational age of 32–37 weeks) with the Bayley Scales of Infant and Toddler Development—3rd Edition. In our selected cohort of EA infants, 82 were evaluated at 6 months and 59 were reevaluated at 12 months. Both Motor and Cognitive average scores were within the norm at both time points. However, we report increased number of infants with motor delay with time: 14% at 6 months and 24% at 12 months. Multiple regression analysis for Motor scores at 6 [F(4,74) = 4.363, P = 0.003] and 12 months [F(6,50) = 2.634, P = 0.027] identified (i) low birth weight, (ii) longer hospital stay and (iii) weight < fifth percentile at 1 year as risk factors. Interestingly, average Cognitive scores also increased with time from 85.2% at 6 months and 96.6% at 12 months. Multiple regression models explaining variance of Cognitive scores at 6 [F(4, 73) = 2.458, P = 0.053] and 12 months [F(6, 49) = 1.232, P = 0.306] were nonsignificant. Our selected cohort of EA patients shows, on the average, Motor and Cognitive scores within the norm both at 6 and 12 months. Nevertheless, the percentage of infants with Motor scores below the average increases regardless gestational age. None of clinical and sociodemographic variables taken into consideration was able to predict cognitive development both at 6 and 12 months whereas risk factors for Motor development change during the first year of life. Healthcare providers should pay particular attention to patients with low birth weight, longer hospital stays and weight under fifth percentile at 1 year. Future studies should include long-term outcomes to reveal possible catch up in motor development and/or possible findings in Cognitive scores.

scholarly journals Outcome in children with brain tumours diagnosed in the first year of life: long-term complications and quality of life

2008 ◽  
Vol 93 (7) ◽  
pp. 582-589 ◽  
Author(s):  
N U Gerber ◽  
D Zehnder ◽  
T J Zuzak ◽  
A Poretti ◽  
E Boltshauser ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumours ◽  
First Year ◽  
First Year Of Life

scholarly journals Effectiveness of Rotarix® vaccine in Africa in the first decade of progressive introduction, 2009-2019:  systematic review and meta-analysis

2020 ◽  
Vol 5 ◽  
pp. 187
Author(s):  
Nickson Murunga ◽  
Grieven P. Otieno ◽  
Marta Maia ◽  
Charles N. Agoti
Keyword(s):  
Meta Analysis ◽  
Age Groups ◽  
Developed Countries ◽  
Point Estimate ◽  
First Year ◽  
Full Dose ◽  
Newcastle Ottawa Scale ◽  
Group A ◽  
First Year Of Life

Background: Randomized controlled trials of licensed oral rotavirus group A (RVA) vaccines, indicated lower efficacy in developing countries compared to developed countries. We investigated the pooled effectiveness of Rotarix® in Africa in 2019, a decade since progressive introduction began in 2009. Methods: A systematic search was conducted in PubMed to identify studies that investigated the effectiveness of routine RVA vaccination in an African country between 2009 and 2019. A meta-analysis was undertaken to estimate pooled effectiveness of the full-dose versus partial-dose of Rotarix® (RV1) vaccine and in different age groups. Pooled odds ratios were estimated using random effects model and the risk of bias assessed using Newcastle-Ottawa scale. The quality of the evidence was assessed using GRADE. Results: By December 2019, 39 (72%) countries in Africa had introduced RVA vaccination, of which 34 were using RV1. Thirteen eligible studies from eight countries were included in meta-analysis for vaccine effectiveness (VE) of RVA by vaccine dosage (full or partial) and age categories. Pooled RV1 VE against RVA associated hospitalizations was 44% (95% confidence interval (CI) 28-57%) for partial dose versus 58% (95% CI 50-65%) for full dose. VE was 61% (95% CI 50-69%), 55% (95% CI 32-71%), 56% (95% CI 43-67%), and 61% (95% CI 42-73%) for children aged <12 months, 12-23 months, <24 months and 12-59 months, respectively. Conclusion: RV1 vaccine use has resulted in a significant reduction in severe diarrhoea in African children and its VE is close to the efficacy findings observed in clinical trials. RV1 VE point estimate was higher for children who received full dose than those who received partial dose, and its protection lasted beyond the first year of life.

scholarly journals The Feeding Infants and Toddlers Study (FITS) 2008: Dramatic changes in the amount and quality of vegetables in the diet occur after the first year of life

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Denise M Deming ◽  
Kathleen C Reidy ◽  
Ronette R Briefel ◽  
Mary Kay Fox ◽  
Elizabeth Condon
Keyword(s):  
First Year ◽  
Infants And Toddlers ◽  
First Year Of Life

INFANT MORTALITY RATES FOR THE TOWN OF SALEM, MASSACHUSETTS, IN 1782 AND 1783

PEDIATRICS ◽  
1966 ◽  
Vol 38 (5) ◽  
pp. 800-800
Author(s):  
T. E. C.
Keyword(s):  
United States ◽  
Mortality Rate ◽  
Infant Mortality ◽  
New England ◽  
The United States ◽  
Infant Mortality Rate ◽  
First Year ◽  
True Index ◽  
First Year Of Life ◽  
The Town

The infant mortality rate for a single New England town for the years 1782 and 1783 cannot be used as a true index of this statistic for the 13 states which made up the United States during the 1780's. As we lack data concerning infant mortality for the country as a whole during this period, information about the mortality of infants in the town of Salem, Massachusetts, where all births were recorded, should be of interest to pediatricians. Doctor Edward A. Holyoke of Salem in a letter to Mr. Caleb Garnett, the Recording Secretary of the American Academy of Arts and Sciences, gave these figures for the town of Salem: In 1782 there were 311 live-born infants and of these 36 died before they reached their first birthday, for an infant mortality rate of 115. In 1783 of 374 live-born infants, 38 died during their first year of life, for an infant mortality of 102. When one recalls that the rate for 1915 in the United States was 100, the infants, at least in Salem, did not fare too badly.

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