Less Severe but Prolonged Course of Acute Hepatitis A in Human Immunodeficiency Virus (HIV)–Infected Patients Compared With HIV-Uninfected Patients During an Outbreak: A Multicenter Observational Study

2018 ◽  
Vol 67 (10) ◽  
pp. 1595-1602 ◽  
Author(s):  
Yu-Lin Lee ◽  
Guan-Jhou Chen ◽  
Nan-Yu Chen ◽  
Bo-Huang Liou ◽  
Ning-Chi Wang ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Observational Study ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Multicenter Observational Study ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis A

scholarly journals 1061. False Positive Human Immunodeficiency Virus Testing Due to Acute Hepatitis A Infection: A Case Series

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S559-S559
Author(s):  
Maria V Bandres ◽  
Daniel Mueller
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acute Hepatitis ◽  
Hiv Testing ◽  
False Positive ◽  
Hepatitis A ◽  
Screening Tests ◽  
Hiv Screening ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis A ◽  
Hiv 1

Abstract Background In our urban, underserved patient population, Human Immunodeficiency Virus (HIV) is hyper-endemic, and HIV screening is frequently performed. Although HIV screening tests have high specificity, false positives can occur. Numerous reasons for false positive testing have been cited, including vaccinations, autoimmune diseases, and viral infections. In 2019, Philadelphia experienced a large Hepatitis A outbreak, during which time false positive HIV screening tests were discovered. Our aim was to further describe these patients who had been diagnosed with acute Hepatitis A infection and in whom false positive HIV testing had occurred. Methods We conducted a retrospective chart review of adult patients admitted to our hospital between January 2017 and December 2019 who had a positive Hepatitis A Virus (HAV) IgM. Demographics, HIV tests, viral hepatitis tests, and liver tests were recorded. False positive HIV was defined as a positive HIV screen (p24 antigen and HIV-1 and 2 antibody combo), followed by a negative differentiation assay for HIV-1 and 2 antibodies, combined with a negative HIV PCR. Results A total of 156 unique patients were found to have acute HAV, with 138 cases identified in 2019. Of these, 3 patients had confirmed false positive HIV testing, and 1 patient had suspected false positive HIV testing (HIV-2 differentiation assay indeterminate, with very low local prevalence of HIV-2), for a false positive test rate of 2.6% (4/156). Ages ranged from 36-47 years, 3 were male, and 2 were persons who injected drugs (PWID). Three patients had prior negative HIV testing. Two patients had fevers during admission, but none of the four were febrile at the time of HIV test collection. Three patients had elevated transaminases, and two had abnormal coagulation testing. Coinfection with Hepatitis C was found in three patients. One patient had follow-up HIV testing performed, which was negative. Conclusion To our knowledge, this is the first report of false positive HIV testing related to acute HAV. Prevalence of false positives was low, but awareness can facilitate patient counseling. With low sample size, conclusions cannot be drawn about risk factors related to false positive testing. Disclosures All Authors: No reported disclosures

Hepatitis E Virus Infections Among Human Immunodeficiency Virus–Positive Individuals During an Outbreak of Acute Hepatitis A in Taiwan

Hepatology ◽  
2019 ◽  
Vol 70 (6) ◽  
pp. 1892-1902 ◽  
Author(s):  
Kuan‐Yin Lin ◽  
Pi‐Han Lin ◽  
Hsin‐Yun Sun ◽  
Yi‐Ting Chen ◽  
Li‐Hsin Su ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Hepatitis E ◽  
Virus Infections ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis A

scholarly journals Occurrence of Acute Hepatitis A in Patients Infected with Human Immunodeficiency Virus

2001 ◽  
Vol 32 (2) ◽  
pp. 297-299 ◽  
Author(s):  
L. Fonquernie ◽  
J. L. Meynard ◽  
A. Charrois ◽  
C. Delamare ◽  
M. C. Meyohas ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis A

Serologic responses and effectiveness of hepatitis A vaccination among human immunodeficiency virus-positive individuals during the outbreak of acute hepatitis A

Hepatology ◽  
2018 ◽  
Vol 68 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Kuan-Yin Lin ◽  
Szu-Min Hsieh ◽  
Hsin-Yun Sun ◽  
Yi-Chun Lo ◽  
Wang-Huei Sheng ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis A

Sources of Infection Among Persons With Acute Hepatitis A and No Identified Risk Factors During a Sustained Community-Wide Outbreak

PEDIATRICS ◽  
2000 ◽  
Vol 106 (4) ◽  
pp. e54-e54 ◽  
Author(s):  
C. J. Staes ◽  
T. L. Schlenker ◽  
I. Risk ◽  
K. G. Cannon ◽  
H. Harris ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Acute Hepatitis A ◽  
Sources Of Infection
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