Influence of Human Immunodeficiency Virus Type 1 Infection on Acute Hepatitis A Virus Infection

2002 ◽  
Vol 34 (3) ◽  
pp. 379-385 ◽  
Author(s):  
S. Ida ◽  
N. Tachikawa ◽  
A. Nakajima ◽  
M. Daikoku ◽  
M. Yano ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis A

scholarly journals Inhibitory role of CXCR4 glycan in CD4-independent X4-tropic human immunodeficiency virus type 1 infection and its abrogation in CD4-dependent infection

2007 ◽  
Vol 88 (11) ◽  
pp. 3139-3144 ◽  
Author(s):  
Yoshinao Kubo ◽  
Masaru Yokoyama ◽  
Hiroaki Yoshii ◽  
Chiho Mitani ◽  
Chika Tominaga ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Viral Envelope ◽  
Extracellular Region ◽  
Immunodeficiency Virus ◽  
Env Protein ◽  
Hiv 1

CXCR4 functions as an infection receptor of X4 human immunodeficiency virus type 1 (HIV-1) . CXCR4 is glycosylated at the N-terminal extracellular region, which is important for viral envelope (Env) protein binding. We compared the effects of CXCR4 glycan on the CD4-dependent and –independent infections in human cells by X4 viruses. We found that transduction mediated by Env proteins of CD4-independent HIV-1 strains increased up to 5.5-fold in cells expressing unglycosylated CXCR4, suggesting that the CXCR4 glycan inhibits CD4-independent X4 virus infection. Co-expression of CD4 on the target cell surface or pre-incubation of virus particles with soluble CD4 abrogates the glycan-mediated inhibition of X4 virus infection, suggesting that interaction of Env protein with CD4 counteracts the inhibition. These findings indicate that it will be advantageous for X4 HIV-1 to remain CD4-dependent. A structural model that explains the glycan-mediated inhibition is discussed.

scholarly journals Hepatitis G Virus Infection in Human Immunodeficiency Virus Type 1‐Infected Mothers and Their Children

1998 ◽  
Vol 178 (3) ◽  
pp. 862-865 ◽  
Author(s):  
Maurizio de Martino ◽  
Chiara Azzari ◽  
Massimo Resti ◽  
Maria Moriondo ◽  
Maria Elisabetta Rossi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Hepatitis G Virus ◽  
Immunodeficiency Virus ◽  
Hepatitis G
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