scholarly journals Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses

2017 ◽  
Vol 65 (suppl_2) ◽  
pp. S100-S111 ◽  
Author(s):  
Neal J Russell ◽  
Anna C Seale ◽  
Megan O’Driscoll ◽  
Catherine O’Sullivan ◽  
Fiorella Bianchi-Jassir ◽  
...  
Keyword(s):  
Systematic Review ◽  
Group B Streptococcus ◽  
Serotype Distribution ◽  
Group B ◽  
Meta Analyses

scholarly journals Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses

2017 ◽  
Vol 65 (suppl_2) ◽  
pp. S112-S124 ◽  
Author(s):  
Jennifer Hall ◽  
Nadine Hack Adams ◽  
Linda Bartlett ◽  
Anna C Seale ◽  
Theresa Lamagni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Group B Streptococcus ◽  
Serotype Distribution ◽  
Group B ◽  
Meta Analyses ◽  
Maternal Disease

scholarly journals Preterm Birth Associated With Group B Streptococcus Maternal Colonization Worldwide: Systematic Review and Meta-analyses

2017 ◽  
Vol 65 (suppl_2) ◽  
pp. S133-S142 ◽  
Author(s):  
Fiorella Bianchi-Jassir ◽  
Anna C Seale ◽  
Maya Kohli-Lynch ◽  
Joy E Lawn ◽  
Carol J Baker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Preterm Birth ◽  
Group B Streptococcus ◽  
Group B ◽  
Meta Analyses

scholarly journals Stillbirth With Group B Streptococcus Disease Worldwide: Systematic Review and Meta-analyses

2017 ◽  
Vol 65 (suppl_2) ◽  
pp. S125-S132 ◽  
Author(s):  
Anna C Seale ◽  
Hannah Blencowe ◽  
Fiorella Bianchi-Jassir ◽  
Nicholas Embleton ◽  
Quique Bassat ◽  
...  
Keyword(s):  
Systematic Review ◽  
Group B Streptococcus ◽  
Group B ◽  
Meta Analyses

scholarly journals Systematic Review and Meta-Analyses of Incidence for Group B Streptococcus Disease in Infants and Antimicrobial Resistance, China

2020 ◽  
Vol 26 (11) ◽  
pp. 2651-2659
Author(s):  
Yijun Ding ◽  
Yajuan Wang ◽  
Yingfen Hsia ◽  
Neal Russell ◽  
Paul T. Heath
Keyword(s):  
Systematic Review ◽  
Antimicrobial Resistance ◽  
Group B Streptococcus ◽  
Group B ◽  
Meta Analyses

scholarly journals Burden of invasive group B Streptococcus disease in non-pregnant adults: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0258030
Author(s):  
Adoración Navarro-Torné ◽  
Daniel Curcio ◽  
Jennifer C. Moïsi ◽  
Luis Jodar
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Systematic Review ◽  
Older Adults ◽  
Antimicrobial Resistance ◽  
Group B Streptococcus ◽  
The Elderly ◽  
Incidence Rates ◽  
Serotype Distribution ◽  
Group B

Background Streptococcus agalactiae or group B Streptococcus (GBS) has emerged as an important cause of invasive disease in adults, particularly among the elderly and those with underlying comorbidities. Traditionally, it was recognised as an opportunistic pathogen colonising and causing disease in pregnant women, neonates, and young infants. Reasons for the upsurge of invasive GBS (iGBS) among the elderly remain unclear, although it has been related to risk factors such as underlying chronic diseases, immunosenescence, impaired inflammatory response, and spread of virulent clones. Antibiotics are successfully as treatment or prophylaxis against iGBS. Several candidate vaccines against iGBS are under development. Objectives To conduct a systematic review of the current literature on invasive GBS in order to determine disease incidence and case fatality ratio (CFR) among non-pregnant adults. Additionally, information on risk factors, clinical presentation, serotype distribution, and antimicrobial resistance was also retrieved. Methods Between January and June 2020, electronic searches were conducted in relevant databases: MEDLINE, EMBASE, Global Health, and SCOPUS. Studies were included in the systematic review if they met the inclusion/exclusion criteria. The authors assessed the selected studies for relevance, risk of bias, outcome measures, and heterogeneity. Meta-analyses on incidence and CFR were conducted after evaluating the quality of methods for assessment of exposure and outcomes. Results Pooled estimates of iGBS incidence in non-pregnant adults 15 years and older were 2.86 cases per 100.000 population (95% CI, 1.68–4.34). Incidence rates in older adults were substantially higher, 9.13 (95%CI, 3.53–17.22) and 19.40 (95%CI, 16.26–22.81) per 100.000 population ≥50 and ≥ 65 years old, respectively. Incidence rates ranged from 0.40 (95% CI, 0.30–0.60) in Africa to 5.90 cases per 100.000 population (95% CI, 4.30–7.70) in North America. The overall CFR was and 9.98% (95% CI, 8.47–11.58). CFR was highest in Africa at 22.09% (95% CI, 12.31–33.57). Serotype V was the most prevalent serotype globally and in North America accounting for 43.48% (n = 12926) and 46,72% (n = 12184) of cases, respectively. Serotype Ia was the second and serotype III was more prevalent in Europe (25.0%) and Asia (29.5%). Comorbidities were frequent among non-pregnant adult iGBS cases. Antimicrobial resistance against different antibiotics (i.e., penicillin, erythromycin) is increasing over time. Conclusions This systematic review revealed that iGBS in non-pregnant adults has risen in the last few years and has become a serious public health threat especially in older adults with underlying conditions. Given the current serotype distribution, vaccines including serotypes predominant among non-pregnant adults (i.e., serotypes V, Ia, II, and III) in their formulation are needed to provide breadth of protection. Continued surveillance monitoring potential changes in serotype distribution and antimicrobial resistance patterns are warranted to inform public health interventions.

Rectovaginal group B streptococcus colonization among pregnant women in Nicaragua: a systematic review and meta-analysis

2019 ◽  
pp. 1-9
Author(s):  
Nadja A. Vielot ◽  
Christian E. Toval-Ruíz ◽  
Rachel Palmieri Weber ◽  
Sylvia Becker-Dreps ◽  
Teresa de Jesús Alemán Rivera
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Group B Streptococcus ◽  
Group B

scholarly journals Group B Streptococcus and the vaginal microbiome among pregnant women: a systematic review

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11437
Author(s):  
Sungju Lim ◽  
Shilpa Rajagopal ◽  
Ye Ryn Jeong ◽  
Dumebi Nzegwu ◽  
Michelle L. Wright
Keyword(s):  
Systematic Review ◽  
Group B Streptococcus ◽  
Taxonomic Composition ◽  
Vaginal Microbiome ◽  
Large Variability ◽  
Microbiome Analysis ◽  
Genus Level ◽  
Level Data ◽  
Subsequent Birth ◽  
Group B

Background Vaginal microbiome studies frequently report diversity metrics and communities of microbiomes associated with reproductive health outcomes. Reports of Streptococcus agalactiae (also known as Group B Streptococcus or GBS), the leading cause of neonatal infectious morbidity and mortality, are notably lacking from the studies of the vaginal microbiome, despite being a known contributor to preterm birth and other complications. Therefore, the purpose of this systematic review was to explore the frequency of GBS reporting in vaginal microbiome literature pertaining to pregnancy and to examine methodological bias that contributes to differences in species and genus-level microbiome reporting. Lack of identification of GBS via sequencing-based approaches due to methodologic or reporting bias may result incomplete understanding of bacterial composition during pregnancy and subsequent birth outcomes. Methodology A systematic review was conducted following the PRISMA guideline. Three databases (PubMed, CINAHL, and Web of Science) were used to identify papers for review based on the search terms “vaginal microbiome”, “pregnancy”, and “16S rRNA sequencing”. Articles were evaluated for methods of DNA extraction and sequencing, 16S region, taxonomy classification database, number of participants or vaginal specimens, and pregnancy trimester. Results Forty-five research articles reported employing a metagenomic approach or 16S approach for vaginal microbiome analysis during pregnancy that explicitly reported taxonomic composition and were included in this review. Less than 30% of articles reported the presence of GBS (N = 13). No significant differences in methodology were identified between articles that reported versus did not report GBS. However, there was large variability across research methods used for vaginal microbiome analysis and species-level bacterial community reporting. Conclusion Considerable differences in study design and data formatting methods may contribute to underrepresentation of GBS, and other known pathogens, in existing vaginal microbiome literature. Previous studies have identified considerable variation in methodology across vaginal microbiome studies. This study adds to this body of work because in addition to laboratory or statistical methods, how results and data are shared (e.g., only analyzing genus level data or 20 most abundant microbes), may hinder reproducibility and limit our understanding of the influence of less abundant microbes. Sharing detailed methods, analysis code, and raw data may improve reproducibility and ability to more accurately compare microbial communities across studies.

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