scholarly journals Human Cytomegalovirus–Specific Memory CD4+ T-Cell Response and Its Correlation With Virus Transmission to the Fetus in Pregnant Women With Primary Infection

2017 ◽  
Vol 65 (10) ◽  
pp. 1659-1665 ◽  
Author(s):  
Chiara Fornara ◽  
Irene Cassaniti ◽  
Maurizio Zavattoni ◽  
Milena Furione ◽  
Kodjo M G Adzasehoun ◽  
...  
Keyword(s):  
T Cell ◽  
Pregnant Women ◽  
Human Cytomegalovirus ◽  
Cell Response ◽  
Primary Infection ◽  
Virus Transmission ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Specific Memory

Prospective study of viral clearance and CD4+ T-cell response in acute hepatitis C primary infection and reinfection

2006 ◽  
Vol 36 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Judith H. Aberle ◽  
Elisabeth Formann ◽  
Petra Steindl-Munda ◽  
Lukas Weseslindtner ◽  
Calin Gurguta ◽  
...  
Keyword(s):  
Hepatitis C ◽  
T Cell ◽  
Prospective Study ◽  
Acute Hepatitis ◽  
Cell Response ◽  
Primary Infection ◽  
T Cell Response ◽  
Viral Clearance ◽  
Cd4 T Cell ◽  
Acute Hepatitis C

scholarly journals Development of Human Cytomegalovirus–Specific T Cell Immunity during Primary Infection of Pregnant Women and Its Correlation with Virus Transmission to the Fetus

2007 ◽  
Vol 195 (7) ◽  
pp. 1062-1070 ◽  
Author(s):  
Daniele Lilleri ◽  
Chiara Fornara ◽  
Milena Furione ◽  
Maurizio Zavattoni ◽  
Maria Grazia Revello ◽  
...  
Keyword(s):  
T Cell ◽  
Pregnant Women ◽  
Human Cytomegalovirus ◽  
Primary Infection ◽  
Virus Transmission ◽  
T Cell Immunity ◽  
Cell Immunity

Human Cytomegalovirus–Specific Memory CD8+and CD4+T Cell Differentiation after Primary Infection

2008 ◽  
Vol 198 (4) ◽  
pp. 536-543 ◽  
Author(s):  
Daniele Lilleri ◽  
Chiara Fornara ◽  
Maria Grazia Revello ◽  
Giuseppe Gerna
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Human Cytomegalovirus ◽  
Primary Infection ◽  
T Cell Differentiation ◽  
Cd4 T Cell ◽  
Specific Memory

scholarly journals Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination

2020 ◽  
Author(s):  
George Elias ◽  
Pieter Meysman ◽  
Esther Bartholomeus ◽  
Nicolas De Neuter ◽  
Nina Keersmaekers ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
High Throughput Sequencing ◽  
Vaccine Development ◽  
Memory T Cells ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Vaccine Antigen ◽  
Specific Memory

AbstractAntigen recognition through the T cell receptor (TCR) αβ heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naïve T cells with high specificity to expand and differentiate into memory T cells that allow for a quick and robust T cell response upon exposure to the pathogen or re-exposure to the vaccine antigen. This is why the induction of memory T cells is a key feature in vaccine development. However, it has become increasingly evident that antigen-specific memory CD4 and CD8 T cells exist in unexposed antigen-naïve hosts and it is likely that exposure to one antigen might alter the TCR repertoire of memory T cells to a different unrelated antigen. In this study, we utilize high-throughput sequencing to profile the memory CD4 TCRβ repertoire and track vaccine-specific TCRβ clonotypes following the de novo administration of hepatitis B (HepB) vaccine in healthy HepB-naïve individuals and show that vaccinees with preexisting vaccine-specific memory CD4 T cell clonotypes elicited earlier and higher antibody concentrations and mounted a more robust CD4 T cell response to the vaccine. We further identify vaccine-specific TCRβ sequence patterns that can be used to predict which individuals will have an early and more vigorous vaccine-elicited immunity to HepB vaccine. Moreover, we find that an expansion of 4-1BB+ memory TREG is a prominent feature in individuals with delayed and modest vaccine-induced immunity. Our approach shows that modeling pre-vaccination TCRβ repertoire enables prediction of both antibody and CD4 responses to vaccines.

Analysis of HIV-1–  and CMV-specific memory CD4 T-cell responses during primary and chronic infection

Blood ◽  
2002 ◽  
Vol 100 (4) ◽  
pp. 1381-1387 ◽  
Author(s):  
Alexandre Harari ◽  
G. Paolo Rizzardi ◽  
Kim Ellefsen ◽  
Donatella Ciuffreda ◽  
Patrick Champagne ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Responses ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cmv Infection ◽  
Cell Responses ◽  
Specific Memory ◽  
Hiv 1

CD4 T-cell–specific memory antiviral responses to human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 of the 16 subjects also had primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV coinfection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1– and CMV-specific interferon-γ–secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV coinfection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T-cell response was significantly greater than that of chronic CMV infection, whereas there were no differences between primary and chronic HIV-1–specific CD4 T-cell responses. A substantial proportion of CD4+CCR7− T cells were infected with HIV-1. These results advance the characterization of antiviral memory CD4 T-cell response and the delineation of the potential mechanisms that likely prevent the generation of a robust CD4 T-cell immune response during primary infection.

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