scholarly journals The Immunodominant CD8 T Cell Response to the Human Cytomegalovirus Tegument Phosphoprotein pp65495–503Epitope Critically Depends on CD4 T Cell Help in Vaccinated HLA-A*0201 Transgenic Mice

2011 ◽  
Vol 187 (5) ◽  
pp. 2172-2180 ◽  
Author(s):  
Michael Reiser ◽  
Andreas Wieland ◽  
Bodo Plachter ◽  
Thomas Mertens ◽  
Jochen Greiner ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
Human Cytomegalovirus ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cd4 T Cell Help ◽  
T Cell Help

scholarly journals The Antiviral CD8+T Cell Response Is Differentially Dependent on CD4+T Cell Help Over the Course of Persistent Infection

2007 ◽  
Vol 179 (2) ◽  
pp. 1113-1121 ◽  
Author(s):  
Christopher C. Kemball ◽  
Christopher D. Pack ◽  
Heath M. Guay ◽  
Zhu-Nan Li ◽  
David A. Steinhauer ◽  
...  
Keyword(s):  
T Cell ◽  
Persistent Infection ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cd4 T Cell Help ◽  
T Cell Help

scholarly journals Promotion of a Subdominant CD8 T Cell Response during Murine Gammaherpesvirus 68 Infection in the Absence of CD4 T Cell Help

2014 ◽  
Vol 88 (14) ◽  
pp. 7862-7869 ◽  
Author(s):  
Michael L. Freeman ◽  
Alan D. Roberts ◽  
Claire E. Burkum ◽  
David L. Woodland ◽  
Marcia A. Blackman
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
Cd4 T Cells ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Cd4 T Cell Help ◽  
T Cell Help

ABSTRACTCD8 and CD4 T cells are each critically important for immune control of murine gammaherpesvirus 68 (γHV68) infection. In immunocompetent mice, acute γHV68 infection results in lifelong latency, but in the absence of CD4 T cell help, mice succumb to viral recrudescence and disease. However, the requirements for CD4 T cell help in the generation and maintenance of antiviral CD8 T cell responses are incompletely understood, and it is unclear whether there are epitope-specific differences in the requirement of CD8 T cells for CD4 help. In this report, we characterized the CD8 T cell response to γHV68 in major histocompatibility complex (MHC) class II−/−mice, which lack CD4 T cells, or after antibody-mediated depletion of CD4 T cells. All antiviral CD8 T cells exhibited marked upregulation of surface expression of the inhibitory receptor programmed death-1 (PD-1), but surprisingly, while the immunodominant memory response appeared to be functionally impaired, helpless CD8 T cells of a subdominant specificity had increased numbers and enhanced functionality. Thus, we demonstrate differential requirements for CD4 help in the antiviral CD8 T cell response to a latent gammaherpesvirus.IMPORTANCEγHV68 is a mouse pathogen closely related to the oncogenic human γHVs, which infect a majority of the world's population. Reactivation of these viruses from latency can lead to complications, disease, and even death. CD4 T cells are required for complete immune control of long-term infection, in part by providing key signals to dendritic cells that in turn instruct optimal antiviral CD8 T cell responses. We have investigated multiple virus-specific CD8 T cell responses during infection and identified a subdominant CD8 T cell response that is numerically and functionally enhanced in the absence of CD4 T cell help. This occurs in spite of high surface expression of an inhibitory receptor and in contrast to the immunodominant response, which is impaired. Our data suggest that signals from CD4 T cells are important in maintaining the CD8 T cell hierarchy during γHV infections.

scholarly journals Induction of cytotoxic T‐cell response by optimal‐length peptides does not require CD4 + T‐cell help

Immunology ◽  
1996 ◽  
Vol 89 (1) ◽  
pp. 41-45 ◽  
Author(s):  
C. FAYOLLE ◽  
U. M. ABDEL‐MOTAL ◽  
L. BERG ◽  
E. DERIAUD ◽  
M. JONDAL ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cytotoxic T Cell ◽  
Optimal Length ◽  
Cd4 T Cell Help ◽  
T Cell Help

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

Nature ◽  
2005 ◽  
Vol 434 (7029) ◽  
pp. 88-93 ◽  
Author(s):  
Edith M. Janssen ◽  
Nathalie M. Droin ◽  
Edward E. Lemmens ◽  
Michael J. Pinkoski ◽  
Steven J. Bensinger ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Memory ◽  
Cell Memory ◽  
Activation Induced Cell Death ◽  
Cd4 T Cell Help ◽  
Cd8 T Cell Memory ◽  
T Cell Help
Sign in / Sign up

Export Citation Format

Share Document