scholarly journals Analysis of False-Negative Human Immunodeficiency Virus Rapid Tests Performed on Oral Fluid in 3 International Clinical Research Studies

2017 ◽  
Vol 64 (12) ◽  
pp. 1663-1669 ◽  
Author(s):  
Marcel E. Curlin ◽  
Roman Gvetadze ◽  
Wanna Leelawiwat ◽  
Michael Martin ◽  
Charles Rose ◽  
...  
2009 ◽  
Vol 16 (7) ◽  
pp. 1091-1092 ◽  
Author(s):  
L. G. Wesolowski ◽  
T. Sanchez ◽  
D. A. MacKellar ◽  
B. M. Branson ◽  
S. F. Ethridge ◽  
...  

ABSTRACT The CDC recommends that a reactive rapid human immunodeficiency virus (HIV) test be confirmed with an approved supplemental test; the performance of an intermediate enzyme immunoassay (EIA) is optional. In support of this recommendation, it was found that of 1,431 reactive rapid HIV test results, 2 (0.1%) had false-negative oral fluid Western blot results and both had false-negative EIA results.


1997 ◽  
Vol 8 (S3) ◽  
pp. 273-279 ◽  
Author(s):  
Eric D. Caine

Establishing a medical diagnosis serves two utilitarian purposes: providing information necessary to initiate treatment and communicating information regarding prognosis. A nosology or diagnostic nomenclature (i.e., a classification of diagnoses) provides further utility by establishing a foundation for clinical research. In his book, Wulff outlined four types of diagnoses: (1) symptomatic or pseudoanatomic diagnoses (e.g., chronic headache, persistent diarrhea, or irritable bowel); (2) syndromes; (3) anatomic diagnoses; and (4) causal diagnoses. By definition, syndromes have no means of being validated by measures external to the constructs themselves. Often, specific syndromes reflect diverse origins, and conversely, specific etiologies may cause multiple syndromes (e.g., syphilis, human immunodeficiency virus, and diabetes).


2010 ◽  
Vol 29 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Gayle G. Sherman ◽  
Rivka R. Lilian ◽  
Ashraf H. Coovadia

2016 ◽  
Vol 2 (2) ◽  
pp. 12-16
Author(s):  
Ahmed Nawsher Alam ◽  
Mahmuda Siddiqua ◽  
Shahina Tabassum ◽  
Md Nazrul Islam

In low prevalent countries of Human Immunodeficiency Virus (HIV) like Bangladesh, it is recommended that all HIVpositive sera tested by Enzyme Linked Immunosorbent Assay (ELISA) and/or rapid tests should be confirmed by Line Immune Assay (LIA) or Western Blot (WB) method. As these two tests are quite expensive, Indirect Immunofluorescence Assay (IFA) was evaluated as a confirmatory test and as an alternative to these two methods in the present study. A total of 92 subjects consisting of 46 HIV-antibody-positive patients and 46 controls were included in the study. All samples of sera were tested by ELISA and IFA methods, and some 34 of 46 HIV-antibody-positive samples were tested by LIA. One ELISA positive serum was found negative by both IFA and LIA. This result indicates that ELISA was 100% sensitive and 98.7% specific for detection of HIV antibody. Comparison between LIA with IFA on 34 samples, and WB with IFA on 26 samples showed 100% correlation between these methods. The study concluded that the IFA method is equal in performance as LIA and WB methods for the detection of antibody to HIV and can be used as a confirmatory test.


2003 ◽  
Vol 36 (10) ◽  
pp. 1313-1317 ◽  
Author(s):  
Ellen M. Tedaldi ◽  
Katherine Huppler Hullsiek ◽  
Carlos D. Malvestutto ◽  
Roberto C. Arduino ◽  
Evelyn J. Fisher ◽  
...  

2008 ◽  
Vol 46 (4) ◽  
pp. 1494-1497 ◽  
Author(s):  
B. Louie ◽  
E. Wong ◽  
J. D. Klausner ◽  
S. Liska ◽  
F. Hecht ◽  
...  

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