scholarly journals Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study

2017 ◽  
Vol 64 (suppl_3) ◽  
pp. S378-S386 ◽  
Author(s):  
Melissa M. Higdon ◽  
Tham Le ◽  
Katherine L. O’Brien ◽  
David R. Murdoch ◽  
Christine Prosperi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Syncytial Virus

scholarly journals Transient Neutropenia in Immunocompetent Infants with Respiratory Syncytial Virus Infection

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 301
Author(s):  
Tatsuya Korematsu ◽  
Hiroshi Koga
Keyword(s):  
Risk Factors ◽  
Respiratory Syncytial Virus ◽  
Streptococcus Pneumoniae ◽  
Moraxella Catarrhalis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serious Infection ◽  
Hematological Disorder ◽  
Rsv Infection ◽  
Syncytial Virus

The incidence of neutropenia and the association between neutropenia and severity of respiratory symptoms among infants with respiratory syncytial virus (RSV) infections remain to be elucidated. This single-center, retrospective study included immunocompetent infants (<10 months old) with laboratory-confirmed RSV infection admitted to our center between January 2012 and December 2019. Incidence of neutropenia (<1.0 × 109/L) within 10 days of onset and risk factors associated with subsequent neutropenia were evaluated. Among the 292 infants with RSV infection, including 232 (79%) with mild infection, neutropenia was observed in 31 (11%), with severe neutropenia (<0.5 × 109/L) in 3 (1.0%). No neutropenic infants developed serious infection or hematological disorder. Infants without neutropenia showed age <3 months at onset in 34%, C-reactive protein level <1.0 mg/L in 27%, and nasopharyngeal microbiota composition with any of Moraxella catarrhalis, Streptococcus pneumoniae, or Haemophilus influenzae in 63%. In comparison, infants with neutropenia showed age <3 months at onset in 74% (relative risk [RR] 2.15; 95% confidence interval [CI] 1.65–2.81), C-reactive protein level <1.0 mg/L in 55% (RR 2.02; 95% CI 1.38–2.94), and microbiota including Moraxella catarrhalis, Streptococcus pneumoniae, or Haemophilus influenzae in 15% (RR 0.24; 95% CI 0.10–0.61). Multiple logistic regression analyses showed that younger age at onset and absence of that nasopharyngeal microbiota profile were associated with development of neutropenia. In conclusion, age and airway microbiota are considered as risk factors for the development of transient neutropenia among infants with RSV infection. However, the neutropenia seems not to develop serious infection or hematological disorder.

scholarly journals Burden of Respiratory Syncytial Virus Associated Severe Pneumonia in Hospitalized Children

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Madhusha Gonapaladeniya ◽  
Thushari Dissanayake ◽  
Guwani Liyanage
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infections ◽  
Tertiary Care ◽  
Severe Pneumonia ◽  
Community Acquired Pneumonia ◽  
Hospitalized Children ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory infections. We examined the burden of RSV-associated severe community-acquired pneumonia among hospitalized children and factors that predict RSV etiology. A hospital-based prospective study examined children below five years of age admitted with radiologically confirmed severe or very severe pneumonia in two tertiary care centers in Sri Lanka. Nasopharyngeal secretions (NPS) were tested for 19 viruses by multiplex RT-PCR. Univariate and multivariate analysis was performed to determine whether RSV etiology could be predicted based on clinical, sociodemographic, environmental, radiological, and laboratory parameters. A total of 108 children with severe or very severe were included in the study. At least one virus was found in NPS in 92.5% of children. Forty-six children had RSV (+) pneumonia. Mean RSV proportion was 42.6% (95% CI: 33.1-52.5%, p value = 0.149). RSV as a single virus was found in 41.3% (19/46). The children with RSV (+) pneumonia were younger ( p = 0.026 ) and had lower C-reactive protein ( p = 0.003 ) and household crowding ( p = 0.012 ) than the RSV (-) group, after controlling for confounding covariates. In conclusion, the present study demonstrated that respiratory syncytial virus was the commonest virus associated with CAP in children under five years. Younger age, crowded housing, and lower C-reactive protein levels were predictors of severe RSV-associated pneumonia.

scholarly journals Importance of respiratory syncytial virus as a predictor of hospital length of stay in bronchiolitis

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 110
Author(s):  
Jefferson Antonio Buendia ◽  
Diana Guerrero Patino
Keyword(s):  
Hospital Stay ◽  
Negative Binomial ◽  
Length Of Hospital Stay ◽  
Negative Binomial Regression ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Negative Binomial Regression Model ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Syncytial Virus

IIntroduction : Bronchiolitis is the leading cause of hospitalization in children. Estimate potentially preventable variables that impact the length of hospital stay are a priority to reduce the costs associated with this disease. This study aims to identify clinical variables associated with length of hospital stay of bronchiolitis in children in a tropical middle-income country Methods: We conducted a retrospective cohort study in 417 infants with bronchiolitis in tertiary centers in Colombia. All medical records of all patients admitted throughto the emergency department were reviewed. To identify factors independently associated we use negative binomial regression model, to estimate incidence rate ratios (IRR) and adjust for potential confounding variables Results : The median of the length of hospital stay was 3.68 days, with a range of 0.774 days to 29 days, 138 (33.117%) of patients have a hospital stay of 5 or more days. After modeling and controlling for potential confounders age <6 months, comorbidities (CHD or neurological), BPD,  chest indrawing, Detection of RSV isolation, and C-reactive protein were independent predictors of LOS Conclusions : Our results show that in infants with bronchiolitis, Detection of RSV isolation, age <6 months, comorbidities (CHD or neurological), BPD,  chest indrawing, and C-reactive protein were independent predictors of LOS. As a potentially modifiable risk factor, efforts to reduce the probability of RSV infection can reduce the high medical cost associates with prolonged LOS in bronchiolitis.

scholarly journals Importance of Respiratory Syncytial Virus as a Predictor of Hospital Length of Stay in Bronchiolitis

2020 ◽  
Author(s):  
jefferson buendia ◽  
Diana Guerrero ◽  
Carlos Rodriguez Martinez
Keyword(s):  
Hospital Stay ◽  
Negative Binomial ◽  
Length Of Hospital Stay ◽  
Negative Binomial Regression ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Negative Binomial Regression Model ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Syncytial Virus

Abstract BackgroundBronchiolitis is the leading cause of hospitalization in children. Estimate potentially preventable variables that impact the length of hospital stay are a priority to reduce the costs associated with this disease.ObjectiveThis study aims to identify clinical variables associated with length of hospital stay of bronchiolitis in children in a tropical middle-income countryMethodsWe conducted a retrospective cohort study in 417 infants with bronchiolitis in tertiary centers in Colombia. All medical records of all patients admitted to the emergency department were reviewed. To identify factors independently associated we use negative binomial regression model, to estimate incidence rate ratios (IRR) and adjust for potential confounding variablesResultsThe median of the length of hospital stay was 3.68 days, with a range of 0.74 days to 29 days, 138 (33.17%) of patients have a hospital stay of 5 or more days. After modeling and controlling for potential confounders age < 6 months, comorbidities (CHD or neurological), BPD, chest indrawing, RSV isolation, and C-reactive protein were independent predictors of LOSConclusionsOur results show that in infants with bronchiolitis, RSV isolation, age < 6 months, comorbidities (CHD or neurological), BPD, chest indrawing, and C-reactive protein were independent predictors of LOS. As a potentially modifiable risk factor, efforts to reduce the probability of RSV infection can reduce the hight medical cost associates with prolonged LOS in bronchiolitis.

scholarly journals #83: Leukocytes and C-Reactive Protein Levels in Children with Influenza-positive and Influenza-negative Viral Pneumonia in a Third-level Pediatric Center in Mexico City from 2011 to 2016

2021 ◽  
Vol 10 (Supplement_1) ◽  
pp. S24-S24
Author(s):  
G H Cristerna Tarrasa ◽  
N González Saldaña ◽  
M Hernández Porras ◽  
S Fortes Gutiérrez
Keyword(s):  
Complete Blood Count ◽  
White Blood Cells ◽  
H1n1 Influenza ◽  
Viral Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Influenza Pneumonia ◽  
Syncytial Virus ◽  
Student’S T

Abstract Background Influenza has been a major source of morbidity and mortality worldwide. Children are one of the most susceptible groups for severe influenza. Clinical differentiation between viral and bacterial pneumonia is difficult to assess in children, so the aid of the complete blood count (CBC) and C-reactive protein (CRP) are used to differentiate between them. However, differential diagnosis between influenza-positive and -negative viral pneumonia is difficult. CRP levels have been found to be higher in H1N1 influenza adult patients. However, there are no studies regarding CBC, and CRP levels in pediatric patients with influenza-positive and -negative pneumonia. Methods From 2011 to 2016, we found children less than 18 years old with viral pneumonia who had positive viral RT–PCR test for adenovirus, bocavirus, influenza, parainfluenza, metapneumovirus, rhinovirus, coronavirus or respiratory syncytial virus (RSV). Means for white blood cells (WBC), neutrophils, lymphocytes and CRP were calculated. Comparisons between influenza and other respiratory viral pneumonia WBC and CRP means were made. Student’s t-test was used for statistical analysis. Results We analyzed 183 patients with positive viral pneumonia cases; of which, 37 (20.2%) had two viruses detected. Mean age was 1 year old and 56.5% were male. Viral detections were rhinovirus 75 (40.9%), RSV 45 (24.5%), influenza 31 (16.9%), metapneumovirus 30 (16.3%), bocavirus 20 (10.9%), parainfluenza 14 (7.6%), coronavirus 3 (1.6%) and adenovirus 2 (1.1%). Mean influenza WBC were 10,900 ± 2040/μL, neutrophils were 6998 ± 1510/μL, lymphocytes 2882 ± 826/μL and CRP 5.41 ± 1.9 mg/dL. Mean influenza negative, viral-positive pneumonia were WBC 12227 ± 868/μL, neutrophils 6787 ± 696/μL, lymphocytes 4469 ± 426/μL, CRP 2.81 ± 0.56 mg/dL. Lower lymphocyte counts (P = 0.002) and higher CRP levels (P = 0.019) were found in patients with influenza comparing them with pneumonia caused by other viruses. Conclusions In our study, children with positive influenza pneumonia showed lower levels of lymphocytes and higher levels of CRP compared with negative influenza. Lower lymphocyte counts and high CRP levels have been found in influenza-positive patients mainly in adult studies. In children with suspected influenza pneumonia, lower lymphocyte counts and higher CRP levels can aid clinical diagnosis before molecular confirmation in influenza pneumonia.

scholarly journals Importance of respiratory syncytial virus as a predictor of hospital length of stay in bronchiolitis

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 110
Author(s):  
Jefferson Antonio Buendia ◽  
Diana Guerrero Patino
Keyword(s):  
Hospital Stay ◽  
Negative Binomial ◽  
Length Of Hospital Stay ◽  
Negative Binomial Regression ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Negative Binomial Regression Model ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Syncytial Virus

Introduction: Bronchiolitis is the leading cause of hospitalization in children. Estimate potentially preventable variables that impact the length of hospital stay are a priority to reduce the costs associated with this disease. This study aims to identify clinical variables associated with length of hospital stay of bronchiolitis in children in a tropical middle-income country Methods: We conducted a retrospective cohort study in 417 infants with bronchiolitis in tertiary centers in Colombia. All medical records of all patients admitted to the emergency department were reviewed. To identify factors independently associated we use negative binomial regression model, to estimate incidence rate ratios (IRR) and adjust for potential confounding variables Results: The median of the length of hospital stay was 3.68 days, with a range of 0.74 days to 29 days, 138 (33.17%) of patients have a hospital stay of 5 or more days. After modeling and controlling for potential confounders age <6 months, comorbidities (CHD or neurological), BPD,  chest indrawing, RSV isolation, and C-reactive protein were independent predictors of LOS Conclusions: Our results show that in infants with bronchiolitis, RSV isolation, age <6 months, comorbidities (CHD or neurological), BPD,  chest indrawing, and C-reactive protein were independent predictors of LOS. As a potentially modifiable risk factor, efforts to reduce the probability of RSV infection can reduce the high medical cost associates with prolonged LOS in bronchiolitis.

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