scholarly journals Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis

2017 ◽  
Vol 64 (10) ◽  
pp. 1328-1334 ◽  
Author(s):  
Sudhir Venkatesan ◽  
Puja R. Myles ◽  
Jo Leonardi-Bee ◽  
Stella G. Muthuri ◽  
Malak Al Masri ◽  
...  
Keyword(s):  
High Risk ◽  
Influenza A ◽  
Neuraminidase Inhibitor ◽  
Individual Participant Data ◽  
Influenza A H1n1 ◽  
Individual Participant ◽  
Inhibitor Treatment

scholarly journals Impact of outpatient neuraminidase inhibitor treatment on hospitalisation in patients infected with influenza A (H1N1)pdm09: An IPD analysis

2016 ◽  
Vol 45 ◽  
pp. 248 ◽  
Author(s):  
S. Venkatesan ◽  
P.R. Myles ◽  
J. Leonardi-Bee ◽  
P. Consortium Investigators ◽  
J.S. Nguyen-Van-Tam
Keyword(s):  
Influenza A ◽  
Neuraminidase Inhibitor ◽  
Influenza A H1n1 ◽  
Inhibitor Treatment

scholarly journals Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

2016 ◽  
Vol 10 (3) ◽  
pp. 192-204 ◽  
Author(s):  
Stella G. Muthuri ◽  
Sudhir Venkatesan ◽  
Puja R. Myles ◽  
Jo Leonardi-Bee ◽  
Wei Shen Lim ◽  
...  
Keyword(s):  
Influenza A ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Neuraminidase Inhibitors ◽  
Influenza A H1n1 ◽  
Individual Participant

scholarly journals Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

2019 ◽  
Author(s):  
Sudhir Venkatesan ◽  
Puja R Myles ◽  
Kirsty J Bolton ◽  
Stella G Muthuri ◽  
Tarig Al Khuwaitir ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Symptom Onset ◽  
Influenza A ◽  
Negative Binomial ◽  
H1n1 Virus ◽  
Meta Analysis ◽  
Hospital Length Of Stay ◽  
Individual Participant Data ◽  
Influenza A H1n1 ◽  
Individual Participant

Abstract Background The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. Methods We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. Results We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78–.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. Conclusions When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment.

scholarly journals Administration of the Adjuvanted pH1N1 Vaccine in Egg-allergic Children at High Risk for Influenza A/H1N1 Disease

2011 ◽  
Vol 102 (3) ◽  
pp. 196-199 ◽  
Author(s):  
Jane E. SchulerCHEO ◽  
W. James King ◽  
Natalie L. Dayneka ◽  
Lynn Rastelli ◽  
Evelyn Marquis ◽  
...  
Keyword(s):  
High Risk ◽  
Influenza A ◽  
Influenza A H1n1

Transmission and control in an institutional pandemic influenza A(H1N1) 2009 outbreak

2011 ◽  
Vol 140 (6) ◽  
pp. 1102-1110 ◽  
Author(s):  
N. ARINAMINPATHY ◽  
N. RAPHAELY ◽  
L. SALDANA ◽  
C. HODGEKISS ◽  
J. DANDRIDGE ◽  
...  
Keyword(s):  
High Risk ◽  
Infection Control ◽  
Pandemic Influenza ◽  
Summer School ◽  
Influenza A ◽  
Control Measures ◽  
Infection Control Measures ◽  
Influenza A H1n1 ◽  
Hygiene Measures ◽  
The Impact

SUMMARYA pandemic influenza A(H1N1) 2009 outbreak in a summer school affected 117/276 (42%) students. Residential social contact was associated with risk of infection, and there was no evidence for transmission associated with the classroom setting. Although the summer school had new admissions each week, which provided susceptible students the outbreak was controlled using routine infection control measures (isolation of cases, basic hygiene measures and avoidance of particularly high-risk social events) and prompt treatment of cases. This was in the absence of chemoprophylaxis or vaccination and without altering the basic educational activities of the school. Modelling of the outbreak allowed estimation of the impact of interventions on transmission. These models and follow-up surveillance supported the effectiveness of routine infection control measures to stop the spread of influenza even in this high-risk setting for transmission.

scholarly journals Characterization of neuraminidase inhibitor-resistant influenza A(H1N1)pdm09 viruses isolated in four seasons during pandemic and post-pandemic periods in Japan

2013 ◽  
Vol 7 (6) ◽  
pp. 1390-1399 ◽  
Author(s):  
Emi Takashita ◽  
Seiichiro Fujisaki ◽  
Noriko Kishida ◽  
Hong Xu ◽  
Masaki Imai ◽  
...  
Keyword(s):  
Influenza A ◽  
Neuraminidase Inhibitor ◽  
Four Seasons ◽  
Influenza A H1n1

scholarly journals Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8

2010 ◽  
Vol 15 (6) ◽  
Author(s):  
U Buchholz ◽  
S Brockmann ◽  
S Duwe ◽  
B Schweiger ◽  
M an der Heiden ◽  
...  
Keyword(s):  
Influenza A ◽  
Case Control Study ◽  
Neuraminidase Inhibitor ◽  
Case Control ◽  
P Value ◽  
Influenza B ◽  
Travel History ◽  
Influenza A H1n1 ◽  
Nested Case Control ◽  
Control Study

During the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested case-control study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting.

scholarly journals Analysis of Spatial-Temporal Distribution of Respiratory Infectious Diseases in Shandong Province, China During 2005-2014

2020 ◽  
Author(s):  
Xiaomei Li ◽  
Dongzhen Chen ◽  
Yan Zhang ◽  
Xiaojia Xue ◽  
Xuewen Li ◽  
...  
Keyword(s):  
High Risk ◽  
Infectious Diseases ◽  
Scarlet Fever ◽  
Influenza A ◽  
Temporal Distribution ◽  
Meningococcal Meningitis ◽  
Shandong Province ◽  
Influenza A H1n1 ◽  
Respiratory Infectious Diseases ◽  
Risk Maps

Abstract Background: Little comprehensive information on overall epidemic trend of respiratory infectious diseases is available in Shandong Province, China. This study aimed to determine the spatiotemporal distribution and epidemic characteristics of respiratory infectious diseases.Methods: Time series was firstly performed to describe the temporal distribution feature of respiratory infectious diseases during 2005-2014 in Shandong Province. GIS Natural Breaks (Jenks) was applied to divide the average annual incidence of respiratory infectious diseases into five grades. Spatial empirical Bayesian smoothed risk maps and excess risk maps were further used to investigate spatial patterns of respiratory infectious diseases. Global and local Moran’s I statistics were used to measure the spatial autocorrelation. Spatial-temporal scanning was used to detect spatiotemporal clusters and identify high-risk locations. Results: A total of 537,506 cases of respiratory infectious diseases were reported in Shandong province during 2005-2014. The morbidity of respiratory infectious diseases had obvious seasonality with high morbidity in winter and spring. Local Moran’s I analysis showed that there were 5, 23, 24, 4, 20, 8, 14, 10 and 7 high-risk counties determined for influenza A (H1N1), measles, tuberculosis, meningococcal meningitis, pertussis, scarlet fever, influenza, mumps and rubella, respectively. The spatial-temporal clustering analysis determined that the most likely cluster of influenza A (H1N1), measles, tuberculosis, meningococcal meningitis, pertussis, scarlet fever, influenza, mumps and rubella included 74, 66, 58, 56, 22, 64, 2, 75 and 56 counties, and the time frame was November 2009, March 2008, January 2007, February 2005, July 2007, December 2011, November 2009, June 2012 and May 2005, respectively.Conclusions: There were obvious spatiotemporal clusters of respiratory infectious diseases in Shandong during 2005–2014. More attention should be paid to the epidemiological and spatiotemporal characteristics of respiratory infectious diseases to establish new strategies for its control.

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