scholarly journals Clinical Manifestations and Molecular Characterization of Pertactin-Deficient and Pertactin-ProducingBordetella pertussisin Children, Philadelphia 2007–2014

2016 ◽  
Vol 64 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Jennifer Vodzak ◽  
Anne Marie Queenan ◽  
Emily Souder ◽  
Alan T. Evangelista ◽  
Sarah S. Long
Keyword(s):  
Molecular Characterization ◽  
Clinical Manifestations

Platelet Function Disorders

2017 ◽  
pp. 117-137
Author(s):  
Zubair A. Karim ◽  
Fadi T. Khasawneh
Keyword(s):  
Clinical Practice ◽  
Molecular Characterization ◽  
Platelet Function ◽  
Clinical Manifestations ◽  
Functional Responses ◽  
Platelet Function Disorders ◽  
Coagulant Activity ◽  
Common Causes ◽  
Adp Receptor

Platelets play an important role in thrombosis and hemostasis. Moreover, platelet dysfunction due to congenital and acquired etiologies is also one of the most common causes of bleeding encountered in clinical practice. Mostly, platelet function disorders are deficiencies of glycoprotein mediators of adhesion and aggregation, whereas defects of primary receptors for stimuli include those of the P2Y12 ADP receptor. Studies on inherited defects of (1) secretion for storage organelles (dense and alpha-granules), (2) the platelet cytoskeleton, and (3) the generation of pro-coagulant activity have allowed for the identification of genes directly and/or indirectly controlling specific functional responses. This chapter will review recent advances in the molecular characterization of platelet function defects, the spectrum of clinical manifestations of these disorders and their management.

scholarly journals Molecular characterization of two rocio flavivirus strains isolated during the encephalitis epidemic in são paulo state, brazil and the development of a one-step rt-pcr assay for diagnosis

2008 ◽  
Vol 50 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Terezinha Lisieux Moraes Coimbra ◽  
Raimundo N. Santos ◽  
Selma Petrella ◽  
Teresa Keico Nagasse-Sugahara ◽  
Silvana Beres Castrignano ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Clinical Manifestations ◽  
Cross Reactivity ◽  
Sao Paulo ◽  
São Paulo ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Paulo State ◽  
São Paulo State

Rocio virus (ROCV) was responsible for an explosive encephalitis epidemic in the 1970s affecting about 1,000 residents of 20 coastland counties in São Paulo State, Brazil. ROCV was first isolated in 1975 from the cerebellum of a fatal human case of encephalitis. Clinical manifestations of the illness are similar to those described for St. Louis encephalitis. ROCV shows intense antigenic cross-reactivity with Japanese encephalitis complex (JEC) viruses, particularly with Ilheus (ILHV), St. Louis encephalitis, Murray Valley and West Nile viruses. In this study, we report a specific RT-PCR assay for ROCV diagnosis and the molecular characterization of the SPAn37630 and SPH37623 strains. Partial nucleotide sequences of NS5 and E genes determined from both strains were used in phylogenetic analysis. The results indicated that these strains are closely related to JEC viruses, but forming a distinct subclade together with ILHV, in accordance with results recently reported by Medeiros et al. (2007).

scholarly journals Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains

2020 ◽  
Vol 7 ◽  
Author(s):  
Natalia Golender ◽  
Velizar Bumbarov ◽  
Avi Eldar ◽  
Alessio Lorusso ◽  
Gabriel Kenigswald ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Clinical Manifestations

1446: Molecular Characterization of Cyclooxygenase-2 in a Stimulated Prostate Stroma Cells

2006 ◽  
Vol 175 (4S) ◽  
pp. 467-467
Author(s):  
Victor K. Lin ◽  
Shih-Ya Wang ◽  
Claus G. Roehrbom
Keyword(s):  
Molecular Characterization ◽  
Cyclooxygenase 2 ◽  
Prostate Stroma

Molecular characterization of lincRNAs in Down syndrome associated leukemia

2012 ◽  
Vol 224 (03) ◽  
Author(s):  
A Streltsov ◽  
S Emmrich ◽  
F Engeland ◽  
JH Klusmann
Keyword(s):  
Down Syndrome ◽  
Molecular Characterization
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