scholarly journals Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients

2016 ◽  
Vol 63 (4) ◽  
pp. 569-570 ◽  
Author(s):  
Sven Pischke ◽  
Jens Hiller ◽  
Marc Lütgehetmann ◽  
Susanne Polywka ◽  
Meike Rybczynski ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Virus Transmission ◽  
Hepatitis E ◽  
Immunosuppressed Patients

Transfusion-transmitted hepatitis E virus infections: a risk for immunosuppressed patients

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
D Westhölter ◽  
J Hartl ◽  
J Hiller ◽  
U Denzer ◽  
S Peine ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Infections ◽  
Immunosuppressed Patients

Safety measures to prevent hepatitis E virus transmission by blood transfusion

Transfusion ◽  
2014 ◽  
Vol 54 (8) ◽  
pp. 2134-2135 ◽  
Author(s):  
Syria Laperche ◽  
Jacques Izopet ◽  
Jean-Jacques Lefrère
Keyword(s):  
Blood Transfusion ◽  
Hepatitis E Virus ◽  
Virus Transmission ◽  
Hepatitis E ◽  
Safety Measures

scholarly journals Comprehensive Evaluation of Hepatitis E Serology and Molecular Testing in a Large Cohort

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Olympia E. Anastasiou ◽  
Viktoria Thodou ◽  
Annemarie Berger ◽  
Heiner Wedemeyer ◽  
Sandra Ciesek
Keyword(s):  
Hepatitis E Virus ◽  
Clinical Laboratory ◽  
Comprehensive Evaluation ◽  
Cost Effective ◽  
Hepatitis E ◽  
Molecular Testing ◽  
Real World Setting ◽  
Immunosuppressed Patients ◽  
Immunocompromised Hosts ◽  
Time Point

Introduction: Reliable and cost-effective diagnostics for hepatitis E virus (HEV) infection are necessary. The aim of our study was to investigate which diagnostic test is most accurate to detect HEV infection in immunocompetent and immunosuppressed patients in a real world setting. Patients and Methods: We performed a retrospective analysis of 1165 patients tested for HEV antibodies and HEV PCR at the same time point. Clinical, laboratory and virological data were taken from patient charts. HEV IgA was measured in a subgroup of 185 patients. Results: HEV RNA was detectable in 61 patients (5.2%); most of them (n = 49, 80.3%/n = 43, 70.5%) were HEV IgM+ and IgG+; however, 12 patients (19.6%) were HEV RNA positive/HEV IgM negative and 17 patients (27.8%) were HEV RNA positive/HEV IgG negative. Ten HEV RNA positive patients (16.4%) had neither HEV IgG nor IgM antibodies. Importantly, all of them were immunosuppressed. HEV IgA testing was less sensitive than HEV IgM for HEV diagnosis. Conclusions: HEV infection can be overlooked in patients without HEV specific antibodies. Performing PCR is necessary to diagnose or exclude HEV infection in immunocompromised hosts. In immunocompetent patients, a screening based on HEV antibodies (IgG/IgM) is sufficient.

scholarly journals Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Aftab Ahmed ◽  
Ijlal Akbar Ali ◽  
Hira Ghazal ◽  
Javid Fazili ◽  
Salman Nusrat
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis E Virus ◽  
Treatment Options ◽  
Antiviral Drug ◽  
Pegylated Interferon ◽  
Hepatitis E ◽  
Recent Advances ◽  
Immunosuppressed Patients ◽  
History Of ◽  
Acute And Chronic Hepatitis

Mysterious aspects of the long presumed to be well-known hepatitis E virus (HEV) have recently surfaced that distinguish it from other hepatotropic viruses. It is a cause of chronic hepatitis in immunosuppressed patients. It has human to human transmission through blood and mantains high seroprevalence in blood donors. HEV has also been found to occur more frequently in the West in those without a history of travel to endemic countries. It has varied extrahepatic manifestations and has multiple non-human reservoirs including pigs and rats. Considering these recent discoveries, it appears odd that HEV is not sought more frequently when working up acute and chronic hepatitis patients. The disease is particularly severe among pregnant women and has a high attack rate in young adults. What adds to its ambiguity is the absence of a well-established diagnostic criteria for its detection and that there is no specific antiviral drug for hepatitis E, except for isolated cases where ribavirin or pegylated interferon alpha has been used with occasional success. This review paper discusses the recent advances in the knowledge of the virus itself, its epidemiology, diagnostic approach and prevention, and the treatment options available.

scholarly journals Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma

2020 ◽  
Vol 26 (12) ◽  
pp. 2881-2886
Author(s):  
Pierre Gallian ◽  
Sébastien Lhomme ◽  
Pascal Morel ◽  
Sylvie Gross ◽  
Carole Mantovani ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Virus Transmission ◽  
Hepatitis E

A Waterborne Outbreak of Hepatitis E Virus Transmission in Southwestern Vietnam

1996 ◽  
Vol 54 (6) ◽  
pp. 559-562 ◽  
Author(s):  
Andrew Lee Corwin ◽  
Vu Thuy Yen ◽  
Junkun He ◽  
Edward T. Clayson ◽  
Pham Kim Sac ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Virus Transmission ◽  
Hepatitis E ◽  
Waterborne Outbreak

scholarly journals Current Paradigm of Hepatitis E Virus Among Pediatric and Adult Patients

2021 ◽  
Vol 9 ◽  
Author(s):  
Oana Belei ◽  
Oana Ancusa ◽  
Adelina Mara ◽  
Laura Olariu ◽  
Elena Amaricai ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Published Data ◽  
Serological Tests ◽  
Vulnerable Patients ◽  
Lower Accuracy ◽  
Immunosuppressed Patients ◽  
Nucleic Acid Analysis ◽  
Limiting Condition ◽  
Current Paradigm

Hepatitis E virus (HEV) infection is a polymorphic condition, present throughout the world and involving children and adults. Multiple studies over the last decade have contributed to a better understanding of the natural evolution of this infection in various population groups, several reservoirs and transmission routes being identified. To date, acute or chronic HEV-induced hepatitis has in some cases remained underdiagnosed due to the lower accuracy of serological tests and due to the evolutionary possibility with extrahepatic manifestations. Implementation of diagnostic tests based on nucleic acid analysis has increased the detection rate of this disease. The epidemiological and clinical features of HEV hepatitis differ depending on the geographical areas studied. HEV infection is usually a self-limiting condition in immunocompetent patients, but in certain categories of vulnerable patients it can induce a sudden evolution toward acute liver failure (pregnant women) or chronicity (immunosuppressed patients, post-transplant, hematological, or malignant diseases). In acute HEV infections in most cases supportive treatment is sufficient. In patients who develop chronic hepatitis with HEV, dose reduction of immunosuppressive medication should be the first therapeutic step, especially in patients with transplant. In case of unfavorable response, the initiation of antiviral therapy is recommended. In this review, the authors summarized the essential published data related to the epidemiological, clinical, paraclinical, and therapeutic aspects of HEV infection in adult and pediatric patients.

Hepatitis E virus transmission to a volunteer

The Lancet ◽  
1993 ◽  
Vol 341 (8838) ◽  
pp. 149-150 ◽  
Author(s):  
A. Chauhan ◽  
J.B. Dilawari ◽  
Y.K. Chawla ◽  
S. Jameel ◽  
U. Kaur ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Virus Transmission ◽  
Hepatitis E

Porcine blood used as ingredient in meat productions may serve as a vehicle for hepatitis E virus transmission

2017 ◽  
Vol 257 ◽  
pp. 225-231 ◽  
Author(s):  
Ingeborg L.A. Boxman ◽  
Claudia C.C. Jansen ◽  
Geke Hägele ◽  
Ans Zwartkruis-Nahuis ◽  
Jeroen Cremer ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Virus Transmission ◽  
Hepatitis E ◽  
Porcine Blood
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