scholarly journals Simultaneous determination of rosuvastatin, naringin and naringenin in rat plasma by RRLC–MS/MS and its application to a pharmacokinetic drug interaction study

2018 ◽  
Vol 56 (7) ◽  
pp. 611-618 ◽  
Author(s):  
Xuan Zeng ◽  
Weiwei Su ◽  
Hong Liu ◽  
Yuying Zheng ◽  
Taobin Chen ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Simultaneous Determination ◽  
Rat Plasma ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug

scholarly journals Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Sijia Gao ◽  
Xuelin Zhou ◽  
Liwei Lang ◽  
Honghong Liu ◽  
Jianyu Li ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Simultaneous Determination ◽  
Water Extract ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Interaction Study ◽  
Triple Quadrupole Mass Spectrometer ◽  
Drug Interaction Study ◽  
Limit Of Quantification

This study aimed to develop a selective, simple, and sensitive HPLC-MS/MS method for the simultaneous determination of schisandrin and promethazine (PMZ) with its metabolite in rat plasma, which was further used for a pharmacokinetic herb-drug interaction study. HPLC-MS/MS analyses were performed on an Agilent Technologies 1290 LC and a 6410 triple quadrupole mass spectrometer. The following parameters, the lower limit of quantification (LLOQ), calibration curve, accuracy, precision, stability, matrix effect, and recovery, were validated. The linear range of the developed method for PMZ, its metabolite promethazine sulfoxide (PMZSO), and schisandrin in rat plasma was 0.5–200 ng/mL (R2 > 0.995), with an LLOQ of 0.5 ng/mL, which completely met the determination requirements of biosamples. The intra- and interday precision (RSD, %) was below 13.31% (below 16.67% for the LLOQ) in various plasma, whose accuracy (bias, %) was from −8.52% to 11.40%, which were both within an acceptable range. This method was successfully applied to a pharmacokinetic herb-drug interaction study after oral administration of PMZ with or without S. chinensis water extract. The results demonstrated that coadministration with the S. chinensis water extract might affect the pharmacokinetic behaviors of PMZ. In turn, when taken together with PMZ, the pharmacokinetic parameters of schisandrin, the main active component of S. chinensis, were also affected. The method established in the current study was selective, simple, sensitive, and widely available with good linearity, high accuracy and precision, and a stable sample preparation process. Moreover, this analytical method provides a significant approach for the investigation of herb-drug interaction between S. chinensis and PMZ. The potential pharmacokinetic herb-drug interaction of PMZ- and schisandrin-containing preparations should be noted.

Simultaneous Determination of Methadone, Fluoxetine, Venlafaxine and Their Metabolites in Rat Plasma by UPLC–MS/MS for Drug Interaction Study

2016 ◽  
Vol 79 (9-10) ◽  
pp. 601-608 ◽  
Author(s):  
Pei-Pei Pan ◽  
Shuang-Hu Wang ◽  
Jun Wang ◽  
Jun Luo ◽  
Pei-Wu Geng ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Simultaneous Determination ◽  
Rat Plasma ◽  
Interaction Study ◽  
Drug Interaction Study

scholarly journals Simultaneous determination of amoxicillin and chloramphenicol and their drug interaction study by the validated UPLC method

2016 ◽  
Vol 10 (5) ◽  
pp. 755-765 ◽  
Author(s):  
Mohammad Nasir Uddin ◽  
Suman Das ◽  
Shakhawat Hasan Khan ◽  
Swapon Kumar Shill ◽  
Habibur Rahman Bhuiyan ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Simultaneous Determination ◽  
Interaction Study ◽  
Drug Interaction Study

Pharmacokinetic Drug Interaction Study of Bazedoxifene and Ibuprofen

2018 ◽  
Vol 7 (4) ◽  
pp. 358-364 ◽  
Author(s):  
William McKeand ◽  
Susan Baird-Bellaire ◽  
James Ermer ◽  
Alain Patat
Keyword(s):  
Drug Interaction ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug

Pharmacokinetic Drug Interaction Study

1998 ◽  
Vol 5 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Elaine Radwanski ◽  
Amin Nomeir ◽  
Chin-Chung Lin ◽  
David Cutler ◽  
Melton Affrime
Keyword(s):  
Drug Interaction ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug
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