Pharmacokinetic Drug Interaction Study of Bazedoxifene and Ibuprofen

2018 ◽  
Vol 7 (4) ◽  
pp. 358-364 ◽  
Author(s):  
William McKeand ◽  
Susan Baird-Bellaire ◽  
James Ermer ◽  
Alain Patat
Keyword(s):  
Drug Interaction ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug

Pharmacokinetic Drug Interaction Study

1998 ◽  
Vol 5 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Elaine Radwanski ◽  
Amin Nomeir ◽  
Chin-Chung Lin ◽  
David Cutler ◽  
Melton Affrime
Keyword(s):  
Drug Interaction ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug

scholarly journals LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY DETERMINATION METHOD OF BENCYCLOQUIDIUM BROMIDE: APPLICATION TO DRUG INTERACTION STUDY IN HUMAN

2021 ◽  
pp. 43-46
Author(s):  
JANVIER ENGELBERT AGBOKPONTO ◽  
LOCONON ACHILLE YEMOA ◽  
ASSOGBA GABIN ASSANHOU ◽  
RUIJUAN LIU ◽  
HABIB GANFON ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Solid Phase ◽  
Storage Conditions ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Limit Of Quantification ◽  
Pharmacokinetic Drug Interaction ◽  
Liquid Chromatography Tandem Mass ◽  
The Stability ◽  
Pharmacokinetic Drug

Objective: This study was conducted to develop a sensitive and effective LC-MS/MS method for the determination of bencycloquidium bromide (BCQB) and its application in pharmacokinetic drug interaction study between BCQB and paroxetine. Methods: The chromatographic separation was performed on Hedera ODS-2 C18 column with a mobile phase consisted of acetonitrile-10 mmol/l ammonium acetate containing 0.2% acetic acid (33:67, v/v) at 550 μl/min, and the plasma samples were processed using solid-phase extraction. The MS/MS transitions were m/z 330.2 → 142.0 for BCQB and m/z 344.2 → 156.1 for the I. S in positive ESI mode. Results: The validated method was linear over the concentration range of 2-1200 pg/ml with the correlation coefficient r2>0.998. The intra-and inter-batch precisions of the assay were lower than 8.2% and 9.1%, respectively. The lower limit of quantification (LLOQ) was 2 pg/ml. The stability data at different storage conditions of BCQB were within±5% RE. The mean AUC0-36 of BCQB was increased by approximately 33%, after the administration of BCQB alone and upon co-administration with paroxetine during the drug interaction study. Conclusion: The LC-MS/MS method validated in this study was robust, reproducible, accurate, precise and reliable and was successfully applied in the pharmacokinetic drug interaction studies.

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