scholarly journals Simultaneous Determination of Antipsychotic Drugs and Their Active Metabolites by LC–MS-MS and its Application to Therapeutic Drug Monitoring

2018 ◽  
Vol 56 (6) ◽  
pp. 510-517 ◽  
Author(s):  
Igor I Miroshnichenko ◽  
Natalia V Baymeeva
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Drug Monitoring ◽  
Antipsychotic Drugs ◽  
Therapeutic Drug ◽  
Active Metabolites

LC-MS for Simultaneous Determination of Vancomycin and Teicoplanin in Patient Plasma and its Application to Therapeutic Drug Monitoring

2018 ◽  
Vol 15 (1) ◽  
pp. 95-102
Author(s):  
Guiyan Yuan ◽  
Danni Liu ◽  
Fanlong Bu ◽  
Yanyan Wang ◽  
Benjie Wang ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Drug Monitoring ◽  
Severe Infection ◽  
Gradient Elution ◽  
Storage Conditions ◽  
Therapeutic Drug ◽  
Individual Response ◽  
Ionization Source

Background: Therapeutic drug monitoring is recommended for patients taking vancomycin and teicoplanin to ensure pharmaceutical efficacy and prevent toxicity. Only few studies were reported regarding the simultaneous determination of vancomycin and teicoplanin in human plasma. Objective: The study aimed at developing and validating a Liquid Chromatography-Mass Spectrometry (LC-MS) method for simultaneous determination and therapeutic drug monitoring of vancomycin and teicoplanin in patients with severe infection. Method: Plasma was processed by protein precipitation extraction. The analytes were separated on a C18 column by gradient elution with 0.1% formic acid and acetonitrile as mobile phase and measured by electrospray ionization source in positive selective ion monitoring mode at m/z 724.7 (vancomycin), 940.7 (teicoplanin) and 329.0 (bergenin). The plasma samples (104) were obtained from patients who were taking vancomycin or teicoplanin for further analysis. Results: The calibration curves were linear within the range of 0.25–40 µg/mL for vancomycin, and 0.5-40 µg/mL for teicoplanin. Either inter- or intra-day precision was less than 10.01 %. The extraction recoveries ranged from 89.99 to 94.29% for vancomycin and from 39.83 to 40.16 % for teicoplanin. Vancomycin and teicoplanin in plasma were stable at various storage conditions. The measured mean trough concentrations were 12.313 µg/mL for vancomycin and 8.765 µg/mL for teicoplanin. Conclusion: This method was successfully applied to therapeutic drug monitoring of vancomycin and teicoplanin in patients. It is with great clinic value for monitoring and predicting the individual response of patients under treatment.

A simple and automated online SPE-LC-MS/MS method for simultaneous determination of olanzapine, fluoxetine and norfluoxetine in human plasma and its application in therapeutic drug monitoring

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 34342-34352 ◽  
Author(s):  
Yiran Fan ◽  
Guanghu Shen ◽  
Ping Li ◽  
Xiaonan Xi ◽  
Haiting Wu ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Drug Monitoring ◽  
Sample Pretreatment ◽  
Therapeutic Drug ◽  
High Quality ◽  
Online Spe

An integration of sample pretreatment automation using online SPE technique could provide an easy to use, efficient, sensitive and high quality methods for TDM.

scholarly journals Determination of Serum/Plasma Concentrations of Psychotropic Drugs in Therapeutic Drug Monitoring

2021 ◽  
pp. 3-13
Author(s):  
I. I. Miroshnichenko ◽  
N. V. Baymeeva ◽  
A. I. Platova
Keyword(s):  
Mental Health ◽  
Therapeutic Drug Monitoring ◽  
Psychotropic Drugs ◽  
Drug Monitoring ◽  
Antipsychotic Drugs ◽  
Plasma Concentrations ◽  
Mental Health Research ◽  
Therapeutic Drug ◽  
Made In

The article considers the main methodological methods of therapeutic drug monitoring (TDM) of psychotropic drugs. Analytical methods that allow performing these studies have been described. It has been given the interpretation, examples and brief results of two studies of TDM of antipsychotic drugs made in FSBSI “Mental Health Research Center” and Psychiatric hospital No.14 in Moscow.

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