scholarly journals Modulation of Hippocampus-Prefrontal Cortex Synaptic Transmission and Disruption of Executive Cognitive Functions by MK-801

2013 ◽  
Vol 25 (5) ◽  
pp. 1348-1361 ◽  
Author(s):  
K. Blot ◽  
S.-i. Kimura ◽  
J. Bai ◽  
A. Kemp ◽  
D. Manahan-Vaughan ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Transmission ◽  
Cognitive Functions ◽  
Mk 801 ◽  
Executive Cognitive Functions

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

scholarly journals Association between functional performance and executive cognitive functions in an elderly population including patients with low ankle–brachial index

2015 ◽  
pp. 839 ◽  
Author(s):  
Naomi Ferreira ◽  
Paulo Januzzi Cunha ◽  
Danielle Irigoyen Costa ◽  
Fernando Santos ◽  
Fernanda Consolim-Colombo ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Elderly Population ◽  
Functional Performance ◽  
Executive Cognitive Functions

scholarly journals Developmental Fractionation of Working Memory and Response Inhibition During Childhood

2007 ◽  
Vol 54 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Satoshi Tsujimoto ◽  
Mariko Kuwajima ◽  
Toshiyuki Sawaguchi
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Response Inhibition ◽  
Cognitive Functions ◽  
Cognitive Abilities ◽  
Childhood Development ◽  
Neural Systems ◽  
Older Children ◽  
Efficient Processing ◽  
The Relationship

Abstract. The lateral prefrontal cortex (LPFC) plays a major role in both working memory (WM) and response inhibition (RI), which are fundamental for various cognitive abilities. We explored the relationship between these LPFC functions during childhood development by examining the performance of two groups of children in visuospatial and auditory WM tasks and a go/no-go RI task. In the younger children (59 5- and 6-year-olds), performance on the visuospatial WM task correlated significantly with that in the auditory WM task. Furthermore, accuracy in these tasks correlated significantly with performance on the RI task, particularly in the no-go trials. In contrast, there were no significant correlations among those tasks in older children (92 8- and 9-year-olds). These results suggest that functional neural systems for visuospatial WM, auditory WM, and RI, especially those in the LPFC, become fractionated during childhood, thereby enabling more efficient processing of these critical cognitive functions.

scholarly journals Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

2011 ◽  
Vol 6 (1) ◽  
pp. 11 ◽  
Author(s):  
Claude M Schofield ◽  
Ruby Hsu ◽  
Alison J Barker ◽  
Caitlyn C Gertz ◽  
Robert Blelloch ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Transmission ◽  
Excitatory Synaptic Transmission ◽  
Microrna Biogenesis

scholarly journals Aberrant Auditory Steady-State Response of Awake Mice After Single Application of the NMDA Receptor Antagonist MK-801 Into the Medial Geniculate Body

2020 ◽  
Vol 23 (7) ◽  
pp. 459-468 ◽  
Author(s):  
Xuejiao Wang ◽  
Yingzhuo Li ◽  
Jingyu Chen ◽  
Zijie Li ◽  
Jinhong Li ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Steady State ◽  
Local Field ◽  
Local Field Potential ◽  
Phase Locking ◽  
Field Potential ◽  
Medial Geniculate Body ◽  
Systemic Administration ◽  
Mk 801 ◽  
Medial Geniculate

Abstract Background Systemic administration of noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 is widely used to model psychosis of schizophrenia (SZ). Acute systemic MK-801 in rodents caused an increase of the auditory steady-state responses (ASSRs), the oscillatory neural responses to periodic auditory stimulation, while most studies in patients with SZ reported a decrease of ASSRs. This inconsistency may be attributable to the comprehensive effects of systemic administration of MK-801. Here, we examined how the ASSR is affected by selectively blocking NMDAR in the thalamus. Methods We implanted multiple electrodes in the auditory cortex (AC) and prefrontal cortex to simultaneously record the local field potential and spike activity (SA) of multiple sites from awake mice. Click-trains at a 40-Hz repetition rate were used to evoke the ASSR. We compared the mean trial power and phase-locking factor and the firing rate of SA before and after microinjection of MK-801 (1.5 µg) into the medial geniculate body (MGB). Results We found that both the AC and prefrontal cortex showed a transient local field potential response at the onset of click-train stimulus, which was less affected by the application of MK-801 in the MGB. Following the onset response, the AC also showed a response continuing throughout the stimulus period, corresponding to the ASSR, which was suppressed by the application of MK-801. Conclusion Our data suggest that the MGB is one of the generators of ASSR, and NMDAR hypofunction in the thalamocortical projection may account for the ASSR deficits in SZ.

Sign in / Sign up

Export Citation Format

Share Document