scholarly journals Object-in-Place Associative Recognition Memory Depends on Glutamate Receptor Neurotransmission Within Two Defined Hippocampal-Cortical Circuits: A Critical Role for AMPA and NMDA Receptors in the Hippocampus, Perirhinal, and Prefrontal Cortices

2013 ◽  
Vol 25 (2) ◽  
pp. 472-481 ◽  
Author(s):  
Gareth Robert Issac Barker ◽  
Elizabeth Clea Warburton
Keyword(s):  
Recognition Memory ◽  
Nmda Receptors ◽  
Glutamate Receptor ◽  
Critical Role ◽  
Associative Recognition ◽  
Cortical Circuits ◽  
Ampa And Nmda Receptors ◽  
Prefrontal Cortices

scholarly journals Aberrant development of excitatory circuits to inhibitory neurons in the primary visual cortex after neonatal binocular enucleation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rongkang Deng ◽  
Joseph P. Y. Kao ◽  
Patrick O. Kanold
Keyword(s):  
Visual Cortex ◽  
Nmda Receptors ◽  
Laser Scanning ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Cortical Circuits ◽  
Retinal Input ◽  
Layer 4 ◽  
Ampa And Nmda Receptors ◽  
Laser Scanning Photostimulation

AbstractThe development of GABAergic interneurons is important for the functional maturation of cortical circuits. After migrating into the cortex, GABAergic interneurons start to receive glutamatergic connections from cortical excitatory neurons and thus gradually become integrated into cortical circuits. These glutamatergic connections are mediated by glutamate receptors including AMPA and NMDA receptors and the ratio of AMPA to NMDA receptors decreases during development. Since previous studies have shown that retinal input can regulate the early development of connections along the visual pathway, we investigated if the maturation of glutamatergic inputs to GABAergic interneurons in the visual cortex requires retinal input. We mapped the spatial pattern of glutamatergic connections to layer 4 (L4) GABAergic interneurons in mouse visual cortex at around postnatal day (P) 16 by laser-scanning photostimulation and investigated the effect of binocular enucleations at P1/P2 on these patterns. Gad2-positive interneurons in enucleated animals showed an increased fraction of AMPAR-mediated input from L2/3 and a decreased fraction of input from L5/6. Parvalbumin-expressing (PV) interneurons showed similar changes in relative connectivity. NMDAR-only input was largely unchanged by enucleation. Our results show that retinal input sculpts the integration of interneurons into V1 circuits and suggest that the development of AMPAR- and NMDAR-only connections might be regulated differently.

scholarly journals Human Hippocampal and Parahippocampal Activity during Visual Associative Recognition Memory for Spatial and Nonspatial Stimulus Configurations

2003 ◽  
Vol 23 (28) ◽  
pp. 9439-9444 ◽  
Author(s):  
Emrah Düzel ◽  
Reza Habib ◽  
Michael Rotte ◽  
Sebastian Guderian ◽  
Endel Tulving ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Associative Recognition

scholarly journals Long-term associative memory in rats: effects of familiarization period in object-place-context recognition test

2019 ◽  
Author(s):  
Shota Shimoda ◽  
Takaaki Ozawa ◽  
Yukio Ichitani ◽  
Kazuo Yamada
Keyword(s):  
Recognition Memory ◽  
Recognition Test ◽  
Associative Memory ◽  
Associative Recognition ◽  
The Novel ◽  
Novelty Preference ◽  
Object Recognition Test ◽  
Spontaneous Recognition ◽  
Familiarization Period

AbstractSpontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.

Are cognitive representations of friends' request refusals implemented in the orbitofrontal and dorsolateral prefrontal cortices? A cognitive neuroscience approach to ‘theory of mind’ in relationships

2006 ◽  
Vol 23 (2) ◽  
pp. 249-265 ◽  
Author(s):  
Alan D. Heisel ◽  
Michael J. Beatty
Keyword(s):  
Theory Of Mind ◽  
Brain Imaging ◽  
Social Relationships ◽  
Cognitive Neuroscience ◽  
Process Model ◽  
Critical Role ◽  
Brain Wave ◽  
Cognitive Representations ◽  
Dorsolateral Prefrontal ◽  
Prefrontal Cortices

Formulating cognitive representations of others' mental states when interpreting behavior (i.e., ‘theory of mind’) rather than merely focusing on the behavior is considered a distinctly human trait which both interpersonal scholars and cognitive neuroscientists agree plays a critical role in the development and maintenance of social relationships. Although brain-imaging studies have led to huge advances in the understanding of memory and language, theories of social relationships remain relatively uninformed by cognitive neuroscience. In the present study, hypotheses regarding the implementation of theory of mind in a relationship context are (a) derived from extant theory and research, and (b) tested via brain-imaging technology. Specifically, spectrum analyses were conducted using brain wave recordings collected by an electroencephalograph (EEG) monitoring oscillations in the gamma range for the orbitofrontal and dorsolateral prefrontal cortices while participants attempted to construct cognitive representations regarding a friend's request refusal. Results indicated statistically greater electrical activity in both cortical regions for participants engaged in the task than for participants in the control condition. The implications of the findings for building a fully elaborated sequential process model of cognitive representations in interpersonal contexts, among other theoretical endeavors, are discussed.

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