scholarly journals Establishing the Dopamine Dependency of Human Striatal Signals During Reward and Punishment Reversal Learning

2012 ◽  
Vol 24 (3) ◽  
pp. 633-642 ◽  
Author(s):  
Marieke E. van der Schaaf ◽  
Martine R. van Schouwenburg ◽  
Dirk E.M. Geurts ◽  
Arnt F.A. Schellekens ◽  
Jan K. Buitelaar ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Reward And Punishment

scholarly journals Population coding of valence in the basolateral amygdala

2018 ◽  
Author(s):  
Xian Zhang ◽  
Bo Li
Keyword(s):  
Associative Learning ◽  
Reversal Learning ◽  
Basolateral Amygdala ◽  
Population Coding ◽  
Neuronal Responses ◽  
Conditioned Stimuli ◽  
Reward And Punishment

AbstractThe basolateral amygdala (BLA) plays an important role in associative learning, by representing both conditioned stimuli (CSs) and unconditioned stimuli (USs) of positive and negative valences, and by forming associations between CSs and USs. However, how such associations are formed and updated during learning remains unclear. Here we show that associative learning driven by reward and punishment profoundly alters BLA neuronal responses at population levels, reducing noise correlations and transforming the representations of CSs to resemble the distinctive valence-specific representations of USs. This transformation is accompanied by the emergence of prevalent inhibitory CS and US responses, and by the plasticity of CS responses in individual BLA neurons. During reversal learning wherein the expected valences are reversed, BLA population CS representations are remapped onto ensembles representing the opposite valences and track the switching in valence-specific behavioral actions. Our results reveal how signals predictive of opposing valences in the BLA evolve during reward and punishment learning, and how these signals might be updated and used to guide flexible behaviors.

scholarly journals Cortical Hemodynamic Mechanisms of Reversal learning using High-Resolution Functional Near-Infrared Spectroscopy: A Pilot Study

2021 ◽  
Author(s):  
charlotte piau ◽  
Mahdi Mahmoudzadeh ◽  
Astrid Kibleur ◽  
Mircea Polosan ◽  
Olivier David ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Reversal Learning ◽  
Near Infrared ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Behavioral Flexibility ◽  
Reward Processing ◽  
Functional Near Infrared Spectroscopy ◽  
Behavioral Abnormalities ◽  
Reward And Punishment

Abstract Background: Reversal learning is widely used to analyze cognitive flexibility and characterize behavioral abnormalities associated with impulsivity and disinhibition. Recent studies using fMRI have focused on regions involved in reversal learning with negative and positive reinforcers. Although the frontal cortex has been consistently implicated in reversal learning, few studies have focused on whether reward and punishment may have different effects on lateral frontal structures in these tasks. Here, in eight healthy subjects, we used functional near infra-red spectroscopy (fNIRS) to characterize brain activity dynamics and differentiate the involvement of frontal structures in learning driven by reward and punishment. Results: We observed functional hemispheric asymmetries between punishment and reward processing by fNIRS following reversal of a learned rule. Moreover, the left dorsolateral prefrontal cortex (l-DLPFC) and inferior frontal gyrus (IFG) were activated under the reward condition only, whereas the orbito-frontal cortex (OFC) was significantly activated under the punishment condition, with a tendency towards activation for the right cortical hemisphere (r-DLPFC and r-IFG). Our results are compatible with the suggestion that the DLPFC is involved in the detection of contingency change. We propose a new representation for reward and punishment, with left lateralization for the reward process. Conclusions: These results provide insights into the indirect neural mechanisms of reversal learning and behavioral flexibility and confirm the use of fNIRS imaging in reversal-learning tasks as a translational strategy, particularly in subjects who cannot undergo fMRI recordings.

scholarly journals Reward and punishment reversal-learning in major depressive disorder.

2020 ◽  
Vol 129 (8) ◽  
pp. 810-823
Author(s):  
Dahlia Mukherjee ◽  
Alexandre L. S. Filipowicz ◽  
Khoi Vo ◽  
Theodore D. Satterthwaite ◽  
Joseph W. Kable
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Reversal Learning ◽  
Major Depressive ◽  
Reward And Punishment

scholarly journals Common Neural Mechanisms Underlying Reversal Learning by Reward and Punishment

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82169 ◽  
Author(s):  
Gui Xue ◽  
Feng Xue ◽  
Vita Droutman ◽  
Zhong-Lin Lu ◽  
Antoine Bechara ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Neural Mechanisms ◽  
Reward And Punishment

scholarly journals Ventral Striatum Response During Reward and Punishment Reversal Learning in Unmedicated Major Depressive Disorder

2012 ◽  
Vol 169 (2) ◽  
pp. 152-159 ◽  
Author(s):  
Oliver J. Robinson ◽  
Roshan Cools ◽  
Christina O. Carlisi ◽  
Barbara J. Sahakian ◽  
Wayne C. Drevets
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Reversal Learning ◽  
Ventral Striatum ◽  
Major Depressive ◽  
Reward And Punishment
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