scholarly journals Genetic and Environmental Contributions to Regional Cortical Surface Area in Humans: A Magnetic Resonance Imaging Twin Study

2011 ◽  
Vol 21 (10) ◽  
pp. 2313-2321 ◽  
Author(s):  
Lisa T. Eyler ◽  
Elizabeth Prom-Wormley ◽  
Matthew S. Panizzon ◽  
Allison R. Kaup ◽  
Christine Fennema-Notestine ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Surface Area ◽  
Twin Study ◽  
Cortical Surface ◽  
Resonance Imaging ◽  
Cortical Surface Area

scholarly journals A Comparison of Heritability Maps of Cortical Surface Area and Thickness and the Influence of Adjustment for Whole Brain Measures: A Magnetic Resonance Imaging Twin Study

2012 ◽  
Vol 15 (3) ◽  
pp. 304-314 ◽  
Author(s):  
Lisa T. Eyler ◽  
Chi-Hua Chen ◽  
Matthew S. Panizzon ◽  
Christine Fennema-Notestine ◽  
Michael C. Neale ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Surface Area ◽  
Cortical Thickness ◽  
Brain Structure ◽  
Twin Study ◽  
Genetic Influences ◽  
Resonance Imaging ◽  
Area Measure ◽  
Regional Patterns

Understanding the genetic and environmental contributions to measures of brain structure such as surface area and cortical thickness is important for a better understanding of the nature of brain-behavior relationships and changes due to development or disease. Continuous spatial maps of genetic influences on these structural features can contribute to our understanding of regional patterns of heritability, since it remains to be seen whether genetic contributions to brain structure respect the boundaries of any traditional parcellation approaches. Using data from magnetic resonance imaging scans collected on a large sample of monozygotic and dizygotic twins in the Vietnam Era Twin Study of Aging, we created maps of the heritability of areal expansion (a vertex-based area measure) and cortical thickness and examined the degree to which these maps were affected by adjustment for total surface area and mean cortical thickness. We also compared the approach of estimating regional heritability based on the average heritability of vertices within the region to the more traditional region-of-interest (ROI)-based approach. The results suggested high heritability across the cortex for areal expansion and, to a slightly lesser degree, for cortical thickness. There was a great deal of genetic overlap between global and regional measures for surface area, so maps of region-specific genetic influences on surface area revealed more modest heritabilities. There was greater inter-regional variability in heritabilities when calculated using the traditional ROI-based approach compared to summarizing vertex-by-vertex heritabilities within regions. Discrepancies between the approaches were greatest in small regions and tended to be larger for surface area than for cortical thickness measures. Implications regarding brain phenotypes for future genetic association studies are discussed.

Regional measurements of pulmonary edema by using magnetic resonance imaging

1998 ◽  
Vol 84 (6) ◽  
pp. 2143-2153 ◽  
Author(s):  
S. D. Caruthers ◽  
C. B. Paschal ◽  
N. A. Pou ◽  
R. J. Roselli ◽  
T. R. Harris
Keyword(s):  
Magnetic Resonance Imaging ◽  
Oleic Acid ◽  
Magnetic Resonance ◽  
Pulmonary Edema ◽  
Surface Area ◽  
Extravascular Lung Water ◽  
Three Dimensional ◽  
Indicator Dilution ◽  
Resonance Imaging ◽  
Lung Water

A three-dimensional magnetic resonance imaging (MRI) method to measure pulmonary edema and lung microvascular barrier permeability was developed and compared with conventional methods in nine mongrel dogs. MRIs were obtained covering the entire lungs. Injury was induced by injection of oleic acid (0.021–0.048 ml/kg) into a jugular catheter. Imaging followed for 0.75–2 h. Extravascular lung water and permeability-related parameters were measured from multiple-indicator dilution curves. Edema was measured as magnetic resonance signal-to-noise ratio (SNR). Postinjury wet-to-dry lung weight ratio was 5.30 ± 0.38 ( n = 9). Extravascular lung water increased from 2.03 ± 1.11 to 3.00 ± 1.45 ml/g ( n = 9, P < 0.01). Indicator dilution studies yielded parameters characterizing capillary exchange of urea and butanediol: the product of the square root of equivalent diffusivity of escape from the capillary and capillary surface area ( D 1/2 S) and the capillary permeability-surface area product ( PS). The ratio of D 1/2 Sfor urea to D 1/2 Sfor butanediol increased from 0.583 ± 0.027 to 0.852 ± 0.154 ( n = 9, P < 0.05). Whole lung SNR at baseline, before injury, correlated with D 1/2 Sand PS ratios (both P < 0.02). By using rate of SNR change, the mismatch of transcapillary filtration flow and lymph clearance was estimated to be 0.2–1.8 ml/min. The filtration coefficient was estimated from these values. Results indicate that pulmonary edema formation during oleic acid injury can be imaged regionally and quantified globally, and the results suggest possible regional quantification by using three-dimensional MRI.

Regional Cortical Surface Area in Adolescents: A Preliminary MRI Twin Study of Genetic and Environmental Contributions

2015 ◽  
Vol 46 (2) ◽  
pp. 205-216 ◽  
Author(s):  
Xingshun Ma ◽  
Lisa T. Eyler ◽  
Xiaomei Hu ◽  
Xiao Hou ◽  
Wei Deng ◽  
...  
Keyword(s):  
Surface Area ◽  
Twin Study ◽  
Cortical Surface ◽  
Cortical Surface Area

scholarly journals Heritability of left ventricular and papillary muscle heart size: a twin study with cardiac magnetic resonance imaging

2009 ◽  
Vol 30 (13) ◽  
pp. 1643-1647 ◽  
Author(s):  
Christoph A. Busjahn ◽  
Jeanette Schulz-Menger ◽  
Hassan Abdel-Aty ◽  
Andre Rudolph ◽  
Jens Jordan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cardiac Magnetic Resonance Imaging ◽  
Papillary Muscle ◽  
Twin Study ◽  
Left Ventricular ◽  
Resonance Imaging ◽  
Heart Size

scholarly journals Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twin study

2010 ◽  
Vol 32 (4) ◽  
pp. 641-653 ◽  
Author(s):  
Lisa T. Eyler ◽  
Elizabeth Prom-Wormley ◽  
Christine Fennema-Notestine ◽  
Matthew S. Panizzon ◽  
Michael C. Neale ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Twin Study ◽  
Resonance Imaging ◽  
Genetic Patterns ◽  
Subcortical Volumes
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