Opposite Effects of Amphetamine Self-administration Experience on Dendritic Spines in the Medial and Orbital Prefrontal Cortex

The orbital prefrontal cortex (PF) receives inputs from the olfactory, gustatory, somatosensory, visceral, and visual cortex. It is also interconnected with the amygdala which represents the current value of the resources, given the internal state of the animal. The worth of the different foods is compared in a ‘common currency’ of value. The central sector of the orbital prefrontal cortex uses vision to predict the value of the resources. These changes depend on the extent to which the animal has already become satiated on a particular food, and an interaction between the amygdala and the orbital PF cortex supports the ability to choose a new food, rather than the one on which the animal has become satiated. The lateral sector of the orbital PF cortex supports the ability to change behaviour depending on the outcome.

Download Full-text

137. Microglial Pruning of Dendritic Spines in the Prefrontal Cortex During Adolescence

Schizophrenia Bulletin ◽

10.1093/schbul/sbx021.195 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S73-S74

Author(s):

Allyson Mallya ◽

Hui-Dong Wang ◽

Tuula Ritakari ◽

Brad Grueter ◽

Ariel Deutch

Keyword(s):

Prefrontal Cortex ◽

Dendritic Spines

Download Full-text

Dopamine Development in the Mouse Orbital Prefrontal Cortex Is Protracted and Sensitive to Amphetamine in Adolescence

eNeuro ◽

10.1523/eneuro.0372-17.2017 ◽

2018 ◽

Vol 5 (1) ◽

pp. ENEURO.0372-17.2017 ◽

Cited By ~ 18

Author(s):

Daniel Hoops ◽

Lauren M. Reynolds ◽

Jose-Maria Restrepo-Lozano ◽

Cecilia Flores

Keyword(s):

Prefrontal Cortex ◽

Orbital Prefrontal Cortex

Download Full-text

The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration

Addiction Biology ◽

10.1111/adb.12896 ◽

2020 ◽

pp. e12896 ◽

Cited By ~ 1

Author(s):

Lucia Caffino ◽

Francesca Mottarlini ◽

Boyd Van Reijmersdal ◽

Francesca Telese ◽

Michel M.M. Verheij ◽

...

Keyword(s):

Prefrontal Cortex ◽

Serotonin Transporter ◽

Self Administration ◽

Glutamatergic Signaling ◽

Long Access

Download Full-text

Dorsal Prefrontal Cortex

10.1093/oso/9780198844570.003.0006 ◽

2021 ◽

pp. 191-235

Author(s):

Richard E. Passingham

Keyword(s):

Prefrontal Cortex ◽

Eye Movements ◽

Frontal Eye Field ◽

Intraparietal Sulcus ◽

Order Information ◽

Shape Information ◽

Eye Field ◽

Orbital Prefrontal Cortex ◽

Ventral Prefrontal Cortex ◽

Premotor Areas

The dorsal prefrontal (PF) cortex generates and plans the goals or targets for foveal search and manual foraging. The goals are conditional on the relative recency of prior events and actions, and the connections of areas 9/46 and 46 explain how these areas can support the ability to generate the next goal. Area 9/46 can generate sequences of eye movements because it has visuospatial inputs from the cortex in the intraparietal sulcus and outputs to the frontal eye field and superior colliculus. Area 46 can generate sequences of hand and arm movements because it has inputs from the inferior parietal areas PFG and SII and outputs to the forelimb regions of the premotor areas and thence to the motor cortex. Both areas get timing and order information indirectly from the parietal cortex and hippocampus, and colour and shape information from the ventral prefrontal cortex. Inputs from the orbital prefrontal cortex enable both areas to integrate generate goals in accordance with current needs.

Download Full-text

Neural Correlates of Strategy Switching in the Macaque Orbital Prefrontal Cortex

Journal of Neuroscience ◽

10.1523/jneurosci.1969-19.2020 ◽

2020 ◽

Vol 40 (15) ◽

pp. 3025-3034

Author(s):

Valeria Fascianelli ◽

Lorenzo Ferrucci ◽

Satoshi Tsujimoto ◽

Aldo Genovesio

Keyword(s):

Prefrontal Cortex ◽

Neural Correlates ◽

Orbital Prefrontal Cortex

Download Full-text

Cocaine self-administration by rats is inhibited by cyclic GMP-elevating agents: involvement of epigenetic markers

The International Journal of Neuropsychopharmacology ◽

10.1017/s1461145712001630 ◽

2013 ◽

Vol 16 (7) ◽

pp. 1587-1597 ◽

Cited By ~ 6

Author(s):

Elodie Deschatrettes ◽

Pascal Romieu ◽

Jean Zwiller

Keyword(s):

Prefrontal Cortex ◽

Cyclic Gmp ◽

Present Report ◽

Fixed Ratio ◽

Signal Transduction Pathway ◽

Adult Brain ◽

Ratio Schedule ◽

Self Administration ◽

Epigenetic Markers ◽

Histone Deacetylase 2

Abstract The C-type natriuretic peptide (CNP) exerts its action via stimulation of the cyclic GMP (cGMP) signalling pathway, which includes the activation of cGMP-dependent protein kinases. The pathway can also be activated by inhibitors of phosphodiesterases (PDE) that hydrolyse cGMP. The present report shows that activation of the cGMP pathway by CNP, by bromo-cGMP, a cell-permeant cGMP analogue, or by the PDE inhibitor zaprinast dose dependently reduces intravenous cocaine self-administration by rats. The effect was found when the compounds were injected in situ into the prefrontal cortex, but not when they were injected into the nucleus accumbens. A decrease in the number of cocaine infusions performed by rats was obtained under the fixed ratio-1 schedule of reinforcement as well as under a progressive ratio schedule, which evaluates the motivation of the animals for the drug. Decrease in cocaine self-administration was accompanied with reduced expression of the epigenetic markers methyl-CpG-binding protein 2 (MeCP2) and histone deacetylase 2 (HDAC2) in dopaminergic projection areas. An increase in the acetylation level of histone H3, but not of histone H4, was also noticed. Since MeCP2 and HDAC2 are known to modulate dynamic functions in the adult brain, such as synaptic plasticity, our results showing that activation of the cGMP signal transduction pathway decreased both cocaine intake and expression of the epigenetic markers strongly suggest that the MeCP2/HDAC2 complex is involved in the analysis of the reinforcing properties of cocaine in the prefrontal cortex.

Download Full-text