Attention and Sentence Processing Deficits in Parkinson's Disease: The Role of Anterior Cingulate Cortex

1992 ◽  
Vol 2 (6) ◽  
pp. 513-525 ◽  
Author(s):  
Murray Grossman ◽  
Peter Crino ◽  
Martin Reivich ◽  
Matthew B. Stem ◽  
Howard I. Hurtig
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Anterior Cingulate Cortex ◽  
Sentence Processing ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Processing Deficits

scholarly journals Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease

2016 ◽  
Vol 195 (5) ◽  
pp. 1613-1620 ◽  
Author(s):  
Takeya Kitta ◽  
Michael B. Chancellor ◽  
William C. de Groat ◽  
Nobuo Shinohara ◽  
Naoki Yoshimura
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Micturition Reflex

scholarly journals Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Zhaoxiang Zhou ◽  
Penghai Ye ◽  
Xu-Hui Li ◽  
Yuxiang Zhang ◽  
Muhang Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Chronic Pain ◽  
Parkinson's Disease ◽  
Synaptic Transmission ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Mechanical Hypersensitivity ◽  
Mptp Treatment ◽  
Emotional Changes

AbstractParkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models. We found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treatment caused significant changes in all measurements. Mechanical hypersensitivity of PD model induced by MPTP peaked at 3 days and persisted for at least 14 days. Using Fos transgenic mice, we found that neurons in the anterior cingulate cortex (ACC) were activated after MPTP treatment. Inhibiting ACC by bilateral microinjection of muscimol significantly reduced mechanical hypersensitivity and anxiety-like responses. By contrast, MPTP induced motor deficit was not affected, indicating ACC activity is mostly responsible for sensory and emotional changes. We also investigated excitatory synaptic transmission and plasticity using brain slices of MPTP treated animals. While L-LTP was blocked or significantly reduced. E-LTP was not significantly affected in slices of MPTP treated animals. LTD induced by repetitive stimulation was not affected. Furthermore, we found that paired-pulse facilitation and spontaneous release of glutamate were also altered in MPTP treated animals, suggesting presynaptic enhancement of excitatory transmission in PD. Our results suggest that ACC synaptic transmission is enhanced in the animal model of PD, and cortical excitation may play important roles in PD related pain and anxiety.

Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease

2003 ◽  
Vol 106 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Enikö Kövari ◽  
Gabriel Gold ◽  
François R. Herrmann ◽  
Alessandra Canuto ◽  
Patrick R. Hof ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Anterior Cingulate Cortex ◽  
Cognitive Deficits ◽  
Lewy Body ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Role of the Anterior Cingulate Cortex in Translational Pain Research

2021 ◽  
Vol 37 (3) ◽  
pp. 405-422
Author(s):  
Xiao Xiao ◽  
Ming Ding ◽  
Yu-Qiu Zhang
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Pain Research

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine
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