scholarly journals Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

2011 ◽  
Vol 33 (2) ◽  
pp. 361-367 ◽  
Author(s):  
E. J. Duell ◽  
N. Sala ◽  
N. Travier ◽  
X. Munoz ◽  
M. C. Boutron-Ruault ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Variation ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Alcohol Dehydrogenase ◽  
Aldehyde Dehydrogenase ◽  
Gastric Cancer Risk ◽  
Prospective Investigation

scholarly journals Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

2011 ◽  
Vol 94 (5) ◽  
pp. 1266-1275 ◽  
Author(s):  
Eric J Duell ◽  
Noémie Travier ◽  
Leila Lujan-Barroso ◽  
Françoise Clavel-Chapelon ◽  
Marie-Christine Boutron-Ruault ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Gastric Cancer Risk ◽  
Prospective Investigation

scholarly journals Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0139059 ◽  
Author(s):  
Ping Sun ◽  
Jiangbo Du ◽  
Xun Zhu ◽  
Chuanli Ren ◽  
Lan Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Chinese Population ◽  
Untranslated Region ◽  
Gastric Cancer Risk ◽  
Nbn Gene

scholarly journals -765 G>C POLYMORPHISM OF THE COX-2 GENE AND GASTRIC CANCER RISK IN BRAZILIAN POPULATION

2014 ◽  
Vol 51 (2) ◽  
pp. 79-83 ◽  
Author(s):  
Vanessa Maria de Lima Pazine CAMPANHOLO ◽  
Aledson Vitor FELIPE ◽  
Jacqueline Miranda de LIMA ◽  
Célia Aparecida Marques PIMENTA ◽  
Rogéria Maria VENTURA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Smoking Behavior ◽  
Personal Data ◽  
Control Group ◽  
Gastric Cancer Risk ◽  
Increased Risk ◽  
Cox 2 ◽  
Gastric Cancer Patients

ContextGenomic alterations play important roles in gastric cancer carcinogenesis. Cyclooxygenases (COX) are important enzymes in the maintenance of mucosal integrity and in pathological processes, mainly in inflammation and cancer. The -765G>C COX-2 polymorphism has been implicated in gastric cancer risk.ObjectivesTo evaluate the COX-2 gene polymorphism as a predictor of gastric cancer risk.MethodsOne hundred gastric cancer patients and 150 controls were enrolled from a Brazilian centre. Personal data regarding related risk factors, including alcohol consumption and smoking behavior, were collected via questionnaire. DNA was extracted from peripheral blood and the genotypes were analyzed using PCR-restriction fragment length polymorphism.ResultsG/G, G/C and C/C genotypes frequencies was 42.7%, 50% and 7.3%, respectively in controls and 59.0%, 34.0% and 7.0% in gastric cancer. The frequency of the genotypes differed between the groups (P = 0.033). A higher risk of gastric cancer was associated with COX-2 -765G/G genotype (P = 0.048; OR:1.98, 95% CI = 1.01-3.90). Alcohol consumption and smoking in patients with -765G/G genotype also increased the risk of gastric cancer.ConclusionsThe -765G/G genotype and the -765G allele had been associated with an increased risk for gastric cancer. The presence of smoking and alcohol consumption increased the risk for gastric cancer in subjects with -765G/G genotype compared with the control group. Polymorphism of COX-2 gene and gastric cancer risk.

scholarly journals Genetic variation and gastric cancer risk: a field synopsis and meta-analysis

Gut ◽  
2015 ◽  
Vol 64 (8) ◽  
pp. 1209-1219 ◽  
Author(s):  
Simone Mocellin ◽  
Daunia Verdi ◽  
Karen A Pooley ◽  
Donato Nitti
Keyword(s):  
Gastric Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Gastric Cancer Risk

scholarly journals Polymorphisms ofHelicobacter pylorisignaling pathway genes and gastric cancer risk in the European prospective investigation into cancer-eurgast cohort

2013 ◽  
Vol 134 (1) ◽  
pp. 92-101 ◽  
Author(s):  
Osmel Companioni ◽  
Catalina Bonet ◽  
Xavier Muñoz ◽  
Elisabete Weiderpass ◽  
Salvatore Panico ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Gastric Cancer Risk ◽  
Prospective Investigation
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