scholarly journals Id-1 expression induces androgen-independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R)

2003 ◽  
Vol 25 (4) ◽  
pp. 517-525 ◽  
Author(s):  
M.-T. Ling
Keyword(s):  
Prostate Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Prostate Cancer Cell ◽  
Growth Factor Receptor ◽  
Cancer Cell Growth ◽  
Epidermal Growth ◽  
Androgen Independent

scholarly journals Correction: DeltaNp63alpha-Mediated Induction of Epidermal Growth Factor Receptor Promotes Pancreatic Cancer Cell Growth and Chemoresistance

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192927
Author(s):  
Alexey V. Danilov ◽  
Divas Neupane ◽  
Archana Sidalaghatta Nagaraja ◽  
Elena V. Feofanova ◽  
Leigh Ann Humphries ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Growth Factor Receptor ◽  
Cancer Cell Growth ◽  
Epidermal Growth

scholarly journals DeltaNp63alpha-Mediated Induction of Epidermal Growth Factor Receptor Promotes Pancreatic Cancer Cell Growth and Chemoresistance

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26815 ◽  
Author(s):  
Alexey V. Danilov ◽  
Divas Neupane ◽  
Archana Sidalaghatta Nagaraja ◽  
Elena V. Feofanova ◽  
Leigh Ann Humphries ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Growth Factor Receptor ◽  
Cancer Cell Growth ◽  
Epidermal Growth

scholarly journals Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells.

1994 ◽  
Vol 5 (3) ◽  
pp. 339-347 ◽  
Author(s):  
I Sehgal ◽  
J Bailey ◽  
K Hitzemann ◽  
M R Pittelkow ◽  
N J Maihle
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Cell Line ◽  
Prostate Cancer Cell ◽  
Carcinoma Cell ◽  
Lncap Cells ◽  
Cancer Cell Growth ◽  
Epidermal Growth

Amphiregulin is a heparin-binding epidermal growth factor (EGF)-related peptide that binds to the EGF receptor (EGF-R) with high affinity. In this study, we report a role for amphiregulin in androgen-stimulated regulation of prostate cancer cell growth. Androgen is known to enhance EGF-R expression in the androgen-sensitive LNCaP human prostate carcinoma cell line, and it has been suggested that androgenic stimuli may regulate proliferation, in part, through autocrine mechanisms involving the EGF-R. In this study, we demonstrate that LNCaP cells express amphiregulin mRNA and peptide and that this expression is elevated by androgenic stimulation. We also show that ligand-dependent EGF-R stimulation induces amphiregulin expression and that androgenic effects on amphiregulin synthesis are mediated through this EGF-R pathway. Parallel studies using the estrogen-responsive breast carcinoma cell line, MCF-7, suggest that regulation of amphiregulin by estrogen may also be mediated via an EGF-R pathway. In addition, heparin treatment of LNCaP cells inhibits androgen-stimulated cell growth further suggesting that amphiregulin can mediate androgen-stimulated LNCaP proliferation. Together, these results implicate an androgen-regulated autocrine loop composed of amphiregulin and its receptor in prostate cancer cell growth and suggest that the mechanism of steroid hormone regulation of amphiregulin synthesis may occur through androgen upregulation of the EGF-R and subsequent receptor-dependent pathways.

Sign in / Sign up

Export Citation Format

Share Document