Autocrine regulation of DU145 human prostate cancer cell growth by epidermal growth factor-related polypeptides

The Prostate ◽  
1991 ◽  
Vol 19 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Jeanne M. Connolly ◽  
David P. Rose
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Prostate Cancer Cell ◽  
Human Prostate Cancer ◽  
Cancer Cell Growth ◽  
Human Prostate Cancer Cell ◽  
Autocrine Regulation ◽  
Epidermal Growth

scholarly journals Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells.

1994 ◽  
Vol 5 (3) ◽  
pp. 339-347 ◽  
Author(s):  
I Sehgal ◽  
J Bailey ◽  
K Hitzemann ◽  
M R Pittelkow ◽  
N J Maihle
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Cell Line ◽  
Prostate Cancer Cell ◽  
Carcinoma Cell ◽  
Lncap Cells ◽  
Cancer Cell Growth ◽  
Epidermal Growth

Amphiregulin is a heparin-binding epidermal growth factor (EGF)-related peptide that binds to the EGF receptor (EGF-R) with high affinity. In this study, we report a role for amphiregulin in androgen-stimulated regulation of prostate cancer cell growth. Androgen is known to enhance EGF-R expression in the androgen-sensitive LNCaP human prostate carcinoma cell line, and it has been suggested that androgenic stimuli may regulate proliferation, in part, through autocrine mechanisms involving the EGF-R. In this study, we demonstrate that LNCaP cells express amphiregulin mRNA and peptide and that this expression is elevated by androgenic stimulation. We also show that ligand-dependent EGF-R stimulation induces amphiregulin expression and that androgenic effects on amphiregulin synthesis are mediated through this EGF-R pathway. Parallel studies using the estrogen-responsive breast carcinoma cell line, MCF-7, suggest that regulation of amphiregulin by estrogen may also be mediated via an EGF-R pathway. In addition, heparin treatment of LNCaP cells inhibits androgen-stimulated cell growth further suggesting that amphiregulin can mediate androgen-stimulated LNCaP proliferation. Together, these results implicate an androgen-regulated autocrine loop composed of amphiregulin and its receptor in prostate cancer cell growth and suggest that the mechanism of steroid hormone regulation of amphiregulin synthesis may occur through androgen upregulation of the EGF-R and subsequent receptor-dependent pathways.

Suppression of human prostate cancer cell growth by forced expression of connexin genes

1999 ◽  
Vol 24 (1-2) ◽  
pp. 91-110 ◽  
Author(s):  
Parmender P. Mehta ◽  
Carlos Perez-Stable ◽  
Mehrdad Nadji ◽  
Mohsin Mian ◽  
Kamlesh Asotra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Cell Growth ◽  
Human Prostate Cancer Cell ◽  
Connexin Genes

scholarly journals PARP1-siRNA suppresses human prostate cancer cell growth and progression

2018 ◽  
Author(s):  
Yongchang Lai ◽  
Zhenzhen Kong ◽  
Tao Zeng ◽  
Shaohong Xu ◽  
Xiaolu Duan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Cell Growth ◽  
Human Prostate Cancer Cell
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