scholarly journals Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

Brain ◽  
2014 ◽  
Vol 137 (9) ◽  
pp. 2493-2508 ◽  
Author(s):  
Hélène Hall ◽  
Stefanie Reyes ◽  
Natalie Landeck ◽  
Chris Bye ◽  
Giampiero Leanza ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology ◽  
Cholinergic Dysfunction

A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

2012 ◽  
Vol 45 (1) ◽  
pp. 305-309 ◽  
Author(s):  
Hélène Pouclet ◽  
Thibaud Lebouvier ◽  
Emmanuel Coron ◽  
Stanislas Bruley des Varannes ◽  
Tiphaine Rouaud ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology ◽  
Colonic Biopsies

Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease

2019 ◽  
Vol 139 (2) ◽  
pp. 319-345 ◽  
Author(s):  
Yi Tan ◽  
Carmelo Sgobio ◽  
Thomas Arzberger ◽  
Felix Machleid ◽  
Qilin Tang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mental Retardation ◽  
Fragile X ◽  
Lewy Pathology ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein

scholarly journals Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles

2020 ◽  
Vol 21 (17) ◽  
pp. 6211 ◽  
Author(s):  
Ha Thi Thu Do ◽  
Jungsook Cho
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Garcinia Mangostana ◽  
Brain Penetration ◽  
Xanthone Derivatives ◽  
Cholinergic Dysfunction ◽  
Therapeutic Value ◽  
Carrier Systems

Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression are growing burdens for society globally, partly due to a lack of effective treatments. Mangosteen (Garcinia mangostana L.,) pericarp (MP) and its xanthones may provide therapeutic advantages for these disorders. In this review, we discuss potential therapeutic value of MP-derived agents in AD, PD, and depression with their pharmacokinetic and safety profiles. MP-derived agents have shown multifunctional effects including neuroprotective, antioxidant, and anti-neuroinflammatory actions. In addition, they target specific disease pathologies, such as amyloid beta production and deposition as well as cholinergic dysfunction in AD; α-synuclein aggregation in PD; and modulation of monoamine disturbance in depression. Particularly, the xanthone derivatives, including α-mangostin and γ-mangostin, exhibit potent pharmacological actions. However, low oral bioavailability and poor brain penetration may limit their therapeutic applications. These challenges can be overcome in part by administering as a form of MP extract (MPE) or using specific carrier systems. MPE and α-mangostin are generally safe and well-tolerated in animals. Furthermore, mangosteen-based products are safe for humans. Therefore, MPE and its bioactive xanthones are promising candidates for the treatment of AD, PD, and depression. Further studies including clinical trials are essential to decipher their efficacy, and pharmacokinetic and safety profiles in these disorders.

A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease

2012 ◽  
Vol 24 (4) ◽  
pp. e202-e205 ◽  
Author(s):  
H. Pouclet ◽  
T. Lebouvier ◽  
E. Coron ◽  
S. B. Des Varannes ◽  
M. Neunlist ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology

Lewy pathology in gastric and duodenal biopsies in Parkinson's Disease

2012 ◽  
Vol 27 (6) ◽  
pp. 708-708 ◽  
Author(s):  
Hélène Pouclet ◽  
Thibaud Lebouvier ◽  
Emmanuel Coron ◽  
Michel Neunlist ◽  
Pascal Derkinderen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology ◽  
Duodenal Biopsies

scholarly journals Variants in the Niemann-Pick type C gene NPC1 are not associated with Parkinson’s disease

2020 ◽  
Author(s):  
Bouchra Ouled Amar Bencheikh ◽  
Konstantin Senkevich ◽  
Uladzislau Rudakou ◽  
Eric Yu ◽  
Kheireddin Mufti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rare Variants ◽  
Transmembrane Protein ◽  
Alpha Synuclein ◽  
Common Variants ◽  
Optimal Sequence ◽  
Lewy Pathology ◽  
Type C ◽  
Niemann Pick

AbstractBiallelic variants in NPC1, a lysosomal gene coding for a transmembrane protein involved in cholesterol trafficking, may cause Niemann-Pick disease type C (NPC). A few cases of NPC1 mutation carriers have been reported with a Parkinson’s disease (PD) presentation. In addition, pathological studies demonstrated phosphorylated alpha-synuclein and Lewy pathology in brains of NPC patients. Therefore, we aimed to examine whether NPC1 genetic variants may be associated with PD. Full sequencing of NPC1 was performed in 2,657 PD patients and 3,647 controls from three cohorts, using targeted sequencing with molecular inversion probes. A total of 9 common variants and 126 rare variants were identified across the three cohorts. To examine association with PD, regression models adjusted for age, sex and origin were performed for common variants, and optimal sequence Kernel association test (SKAT-O) was performed for rare variants. After correction for multiple comparisons, common and rare NPC1 variants were not associated with PD. Our results do not support a link between heterozygous variants in NPC1 and PD.

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