scholarly journals Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitis

Brain ◽  
2013 ◽  
Vol 136 (8) ◽  
pp. 2474-2485 ◽  
Author(s):  
Yoni Pertzov ◽  
Thomas D. Miller ◽  
Nikos Gorgoraptis ◽  
Diana Caine ◽  
Jonathan M. Schott ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Limbic Encephalitis ◽  
Voltage Gated

scholarly journals Anti-voltage-gated potassium channel complex antibody–mediated limbic encephalitis: a case report of a 53-year-old man admitted to intensive care psychiatric unit with psychotic mania

2020 ◽  
Vol 33 (4) ◽  
pp. e100196
Author(s):  
Homayun Shahpesandy ◽  
Rosemary Mohammed-Ali ◽  
Ahmed Oladosu ◽  
Tarik Al-Kubaisy ◽  
Moses Anene ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Medial Temporal Lobe ◽  
Short Term Memory ◽  
Limbic Encephalitis ◽  
Neuropsychiatric Symptoms ◽  
Autoimmune Encephalitis ◽  
Clonic Seizure ◽  
Neurological Symptoms ◽  
Psychiatric Symptomatology ◽  
Voltage Gated

Limbic encephalitis represents a cluster of autoimmune disorders, with inflammation in the medial temporal lobe characterised by subacute onset of neuropsychiatric symptoms such as anxiety, affective symptoms, psychosis, short-term memory impairment as well as faciobrachial and grand mal seizures. We aim to present a case of a 53-year-old man with positive anti–voltage-gated potassium channel (VGKC) complex antibodies who initially presented with symptoms of psychotic mania. Six weeks post-psychiatric symptomatology, he presented with neurological symptoms such as faciobrachial jerking and tonic-clonic seizure. The patient had no previous psychiatric history and was initially treated with psychotropic medications. Our experience emphasises the fact that limbic encephalitis is not easy to identify as most patients initially present with psychiatric symptomatology than neurological symptoms. Furthermore, immunological and laboratory testing takes a rather long time to determine the diagnosis. What is more, few psychiatrists consider autoimmune nature of the neuropsychiatric presentation. Therefore, it is important to consider autoimmune encephalitis in patients with new-onset psychosis or mania who also present with neurological symptoms at some stage of their illness. Characteristic indicators of autoimmune encephalitis include neurological symptoms such as facial twitching, seizures, confusion and cognitive decline.

Limbic encephalitis with voltage gated potassium channel antibodies in a child

2008 ◽  
Vol 39 (01) ◽  
Author(s):  
E Haberlandt ◽  
CG Bien ◽  
A Reiter ◽  
B Simma ◽  
R Crazzolara ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Voltage Gated

Voltage-gated potassium channel limbic encephalitis presenting as functional cognitive impairment

2020 ◽  
Vol 13 (12) ◽  
pp. e233179
Author(s):  
Eric Garrels ◽  
Fawziya Huq ◽  
Gavin McKay
Keyword(s):  
Cognitive Impairment ◽  
Case Report ◽  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Psychiatric Symptoms ◽  
Differential Diagnoses ◽  
Visual Hallucinations ◽  
Voltage Gated ◽  
History Of ◽  
Impaired Cognition

Limbic encephalitis is often reported to present as seizures and impaired cognition with little focus on psychiatric presentations. In this case report, we present a 49-year-old man who initially presented to the Psychiatric Liaison Service with a several month history of confusion with the additional emergence of visual hallucinations and delusions. Due to the inconsistent nature of the symptoms in the context of a major financial stressor, a provisional functional cognitive impairment diagnosis was made. Investigations later revealed a positive titre of voltage-gated potassium channel (VGKC) antibodies, subtype leucine-rich glioma inactivated 1 accounting for his symptoms which dramatically resolved with steroids and immunoglobulins. This case highlighted the need for maintaining broad differential diagnoses in a patient presenting with unusual psychiatric symptoms.

Reversible Dementia: Two Nursing Home Patients With Voltage-Gated Potassium Channel Antibody-Associated Limbic Encephalitis

2015 ◽  
Vol 16 (9) ◽  
pp. 790-794 ◽  
Author(s):  
Wesley Reintjes ◽  
Marloes D.M. Romijn ◽  
Daan Hollander ◽  
Jan P. ter Bruggen ◽  
Rob J. van Marum
Keyword(s):  
Nursing Home ◽  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Voltage Gated ◽  
Nursing Home Patients

A case of voltage-gated potassium channel antibody-related limbic encephalitis

2006 ◽  
Vol 2 (6) ◽  
pp. 339-343 ◽  
Author(s):  
Tim Harrower ◽  
Tom Foltynie ◽  
Luke Kartsounis ◽  
Rajith N De Silva ◽  
John R Hodges
Keyword(s):  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Voltage Gated

scholarly journals Anti–Voltage-gated Potassium Channel Limbic Encephalitis with Psychiatric Features: a Case Report

2019 ◽  
Vol 29 (3) ◽  
pp. 95-96 ◽  
Author(s):  
Jia Min Hee ◽  
Sheng Hng Keith Low ◽  
Shian Ming Tan
Keyword(s):  
Case Report ◽  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Voltage Gated
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