scholarly journals Autologous olfactory ensheathing cell transplantation in human spinal cord injury

Brain ◽  
2005 ◽  
Vol 128 (12) ◽  
pp. 2951-2960 ◽  
Author(s):  
F. Féron ◽  
C. Perry ◽  
J. Cochrane ◽  
P. Licina ◽  
A. Nowitzke ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Olfactory Ensheathing Cell ◽  
Human Spinal Cord ◽  
Cord Injury

scholarly journals Safety and Feasibility of Autologous Olfactory Ensheathing Cell and Bone Marrow Mesenchymal Stem Cell Co-transplantation in Chronic Human Spinal Cord Injury: A Clinical Trial

2021 ◽  
Author(s):  
Homa Zamani ◽  
Mina Soufizomorrod ◽  
Saeed Oraee-Yazdani ◽  
Dariush Naviafar ◽  
Mohammadhosein Akhlaghpasand ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Safety Issue ◽  
Functional Evaluation ◽  
Olfactory Ensheathing Cell ◽  
Human Spinal Cord ◽  
Cord Injury

Abstract Cell-based therapies are considered as promising strategies for spinal cord regeneration. However, a combinatorial cell therapeutic approach seems more beneficial as it can target various aspects of the injury. Here, we assessed the safety and feasibility of autologous mucosal Olfactory Ensheathing Cell (OEC) and bone marrow Mesenchymal Stem Cell (MSC) co-transplantation in patients with chronic, complete (American Spinal Injury Association (ASIA) classification A) Spinal Cord Injury (SCI). Three patients with the traumatic SCI of the thoracic level were enrolled. They received autologous OEC and MSC combination through the lumbar puncture. All adverse events and possible functional outcomes were documented performing pre- and post-operative general clinical examination, Magnetic Resonance Imaging (MRI), neurological assessment based on the International Standard of Neurological Classification for SCI (ISNCSCI), and functional evaluation using Spinal Cord Independence Measure version III (SCIM III). No serious safety issue was recorded during the two years of follow-up. MRI findings remained unchanged with no neoplastic tissue formation. ASIA impairment scale improved from A to B in one of the participants. SCIM III evaluation also showed some degrees of progress in this patient's quality of life. The two other patients had negligible or no improvement in their sensory scores without any changes in the ASIA impairment scale and SCIM III scores. No motor recovery was observed in any of the participants. Overall, this two-year trial was not associated with any adverse findings, which may suggest the safety of autologous OEC and bone marrow MSC combination for the treatment of human SCI.This study was registered at the Iranian Registry of Clinical Trials (IRCT registration number: IRCT20160110025930N2/ registration date: 2018-09-29).

scholarly journals Comparison of intramedullary transplantation of olfactory ensheathing cell for patients with chronic complete spinal cord injury worldwide

2018 ◽  
Vol 1 (1) ◽  
pp. 146-151 ◽  
Author(s):  
Lin Chen ◽  
Yuqi Zhang ◽  
Xijing He ◽  
Saberi Hooshang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Clinical Results ◽  
Postoperative Management ◽  
Olfactory Ensheathing Cells ◽  
Olfactory Ensheathing Cell ◽  
Advantages And Disadvantages ◽  
Cord Injury ◽  
Ensheathing Cells

Objectives:Traumatic spinal cord injury (tSCI) remains a major clinical challenge. Cell transplantation brings a glimmer of light, among them olfactory ensheathing cells (OECs) have shown some neurorestorative effect. Due to the results of each group lack basic consistency, many technical details are believed to affect the overall outcome. We compare the clinical outcome of intramedullary transplant of olfactory ensheathing cells for patients with spinal cord injury at multi-centers worldwide, and to explore the potential standardized transplantation that suits for the clinical requirements.Methods:Here, we used the Pubmed and CNKI databases to search online the literatures published in the last 20 years for the clinical studies/trials of OECs for chronic spinal cord injury in the representative clinical center. The results of these representative clinical treatment centers were searched and analyzed. The parameters which may affect the effect including the concentration of cells, the total number of cells, the choice of incision, the site of transplantation, the number of transplantation sites, the advantages and disadvantages of transplantation equipment, and postoperative management, were compared carefully to clarify its impact on the clinical results.Results:In these literatures, 2 Chinese centers, 1 Australian center and 1 European center were selected for intraspinal transplantation. The reason of different results may be due to the excessive injection times and/or the excessive total injection volume.Conclusions:Cell implant to the spinal cord parenchyma is effective for restoring neurological functions, but improper procedures may lead to ineffective results. Concise surgery appears to be more suitable for clinical application than ostensibly precise and complex injection procedures. Sufficient rehabilitation training is surely necessary for the integration of motor recovery after cell transplantation.

Optimizing Olfactory Ensheathing Cell Transplantation for Spinal Cord Injury Repair

2020 ◽  
Vol 37 (5) ◽  
pp. 817-829 ◽  
Author(s):  
Aaron D. Gilmour ◽  
Ronak Reshamwala ◽  
Alison A. Wright ◽  
Jenny A.K. Ekberg ◽  
James A. St John
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Olfactory Ensheathing Cell ◽  
Injury Repair ◽  
Cord Injury

Motor recovery following olfactory ensheathing cell transplantation in rats with spinal cord injury

2011 ◽  
Vol 59 (4) ◽  
pp. 566 ◽  
Author(s):  
George Tharion ◽  
M Durai ◽  
SureshR Devasahayam ◽  
Cassandra Solomons ◽  
K Indirani ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Motor Recovery ◽  
Olfactory Ensheathing Cell ◽  
Cord Injury
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