scholarly journals Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study

Brain ◽  
2004 ◽  
Vol 127 (1) ◽  
pp. 111-119 ◽  
Author(s):  
J. Wuerfel
Keyword(s):  
Multiple Sclerosis ◽  
Cerebral Perfusion ◽  
Plaque Formation ◽  
Perfusion Mri ◽  
Mri Study

Spinal multiple sclerosis: A clinical and MRI study

1995 ◽  
Vol 56-63 ◽  
pp. 44-44
Author(s):  
JW Thorpe ◽  
AJ Thompson ◽  
IF Moseley ◽  
DAS Compston ◽  
WI McDonald ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mri Study

Interhemispherical predictors of disability and upper limb motor impairment in patients with multiple sclerosis: A structural and functional MRI study

2021 ◽  
Vol 429 ◽  
pp. 117667
Author(s):  
Claudio Cordani ◽  
Paola Valsasina ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Tetsu Morozumi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Mri ◽  
Upper Limb ◽  
Motor Impairment ◽  
Mri Study

scholarly journals Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

2018 ◽  
Vol 40 (1) ◽  
pp. 99-106 ◽  
Author(s):  
G. Pontillo ◽  
S. Cocozza ◽  
R. Lanzillo ◽  
C. Russo ◽  
M.D. Stasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Multimodal Mri ◽  
Deep Gray Matter ◽  
Mri Study

scholarly journals Tumefactive Multiple Sclerosis Clinically Mimicking Acute Stroke and Lesional Migration Along the Biopsy Tract: A Case Report

2019 ◽  
Vol 19 (2) ◽  
pp. 148-153
Author(s):  
Oranan Tritanon ◽  
Arunee Singhsnaeh ◽  
Jiraporn Laothamatus ◽  
Atthaporn Boongird ◽  
Disya Ratanakorn ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Acute Stroke ◽  
Demyelinating Disease ◽  
Internal Capsule ◽  
Chronic Inflammatory Cell ◽  
Left Frontal Lobe ◽  
Lentiform Nucleus ◽  
Mri Study ◽  
Tumefactive Multiple Sclerosis

Tumefactive multiple sclerosis is a form of demyelinating disease which patient can present with acute stroke. We reported a case of a 49-year-old woman with well controlled hypertension, who presented with right hemiplegia 15 hours prior to admission. The initial diagnosis of acute stroke was made. Emergency computed tomography showed hypodense lesion at the left lentiform nucleus and posterior limb of the left internal capsule. The magnetic resonance imaging (MRI) study showed hyperintense FLAIR lesion in the left lentiform nucleus, left internal capsule, left thalamus, and periventricular area of the left frontoparietal region, some areas of restricted diffusion and inhomogeneous enhancement. The MR spectroscopy (MRS) of the lesion showed increased choline peak, decreased creatine and NAA peaks, and maximal choline to creatine ratio 2.25. Her symptoms deteriorated with progressive headache and motor aphasia. The follow up MRI showed extension of the inhomogeneous enhancing lesion along the biopsy tract at the left frontal lobe with the enhancing and MR spectra pattern similar to the lesion. The craniotomy with left frontal lesion excision included the mass and the biopsy tract was done. The lesion showed acute and chronic inflammatory cell infiltration with macrophages, necrotic tissue and reactive gliosis. The further pathological worked up demonstrated foci of demyelination with relative axonal preservation, numerous CD68+ macrophages with intracyto-plasmic Luxol fast blue(+) myelin debris. Perivascular and parenchymal CD3+ T-cells were identified, especially in demyelinating foci. These findings supported the diagnosis of tumefactive multiple sclerosis. Her conditions were improved after treating with pulse methylprednisolone and intravenous immunoglobulin (IVIG). Follow up MRI study 4 months after treatment revealed almost resolution of the preexisting inhomogeneous enhancing lesion.

scholarly journals Disconnection Mechanism and Regional Cortical Atrophy Contribute to Impaired Processing of Facial Expressions and Theory of Mind in Multiple Sclerosis: A Structural MRI Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82422 ◽  
Author(s):  
Andrea Mike ◽  
Erzsebet Strammer ◽  
Mihaly Aradi ◽  
Gergely Orsi ◽  
Gabor Perlaki ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Theory Of Mind ◽  
Facial Expressions ◽  
Structural Mri ◽  
Cortical Atrophy ◽  
Mri Study

Objective duplex ultrasound evaluation of the extracranial circulation in multiple sclerosis patients undergoing venoplasty of internal jugular vein stenoses: A pilot study

2013 ◽  
Vol 30 (2) ◽  
pp. 98-104 ◽  
Author(s):  
P Thibault ◽  
W Lewis ◽  
S Niblett
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Perfusion ◽  
Objective Assessment ◽  
Duplex Ultrasound ◽  
Additional Parameter ◽  
Non Invasive ◽  
Venous Circulation ◽  
Ultrasound Evaluation ◽  
Multiple Sclerosis Patients

Objective Chronic cerebrospinal venous insufficiency (CCSVI) is a condition associated with multiple sclerosis (MS) and manifested by stenoses in the extracranial venous circulation. There is a need for an objective non-invasive assessment of CCSVI that is able to accurately identify the location of stenoses and quantify physiological changes in blood flows following treatment. Method A duplex ultrasound method, extracranial duplex ultrasound (ECDU), is described where the internal jugular veins (IJVs) and vertebral veins (VVs) were examined in the supine and sitting position before and after venoplasty in eight patients with clinically diagnosed MS. High-resolution B-mode imaging was used to detect obvious stenoses, intra-luminal membranes, valve abnormalities and vein wall thickening. ECDU was then used to assess blood flow including reflux. To assess obstruction, venous blood volume flows (BVFs) were taken bilaterally from the proximal (J1), mid (J2) and distal (J3) segments of the IJVs and the mid cervical VVs. To assess cerebral perfusion, bilateral BVF measurements were taken, in the supine position only, from the proximal internal carotid arteries (ICA) and mid cervical vertebral arteries (VA). The global arterial cerebral blood flow (GACBF) was then calculated as the sum of the ICA and VA measurements. Results Pre-venography ECDU detected IJV stenoses or obstruction in all patients. Venography findings were consistent with those of the pre-treatment ECDU with the exception of the detection of bilateral IJV stenoses in two patients diagnosed with unilateral IJV stenosis by ECDU. A significant improvement in GACBF was evident following venoplasty ( p < 0.05). A trend to improvement in the post-treatment BVFs of both the IJVs and the mid cervical VVs was also observed. This improvement was most marked in the left VVs ( p = 0.052) and the J2 segment of right IJVs ( p < 0.05). Conclusion The ECDU examination described provides a reliable objective assessment of IJV and VV stenoses and, with the use of BVFs, can quantify the degree of obstruction. These results support the use of ECDU as a non-invasive post-operative assessment of the success of venoplasty. The ability of ECDU to measure GACBF provides an additional parameter to monitor vascular pathophysiology in MS patients. The current findings support the view that the early symptomatic benefits observed after venoplasty for stenoses in the extracranial venous circulation may be the result of increased cerebral perfusion.

Unraveling the substrates of cognitive impairment in multiple sclerosis: A multiparametric structural and functional MRI study

2021 ◽  
Author(s):  
Lorenzo Conti ◽  
Paolo Preziosa ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Paola Valsasina ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Mri Study
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