Unraveling the substrates of cognitive impairment in multiple sclerosis: A multiparametric structural and functional MRI study

2021 ◽  
Author(s):  
Lorenzo Conti ◽  
Paolo Preziosa ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Paola Valsasina ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Mri Study

Cognitive impairment in benign multiple sclerosis: a multiparametric structural and functional MRI study

2020 ◽  
Vol 267 (12) ◽  
pp. 3508-3517
Author(s):  
Gianna C. Riccitelli ◽  
Elisabetta Pagani ◽  
Alessandro Meani ◽  
Paola Valsasina ◽  
Paolo Preziosa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Benign Multiple Sclerosis ◽  
Mri Study

Interhemispherical predictors of disability and upper limb motor impairment in patients with multiple sclerosis: A structural and functional MRI study

2021 ◽  
Vol 429 ◽  
pp. 117667
Author(s):  
Claudio Cordani ◽  
Paola Valsasina ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Tetsu Morozumi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Mri ◽  
Upper Limb ◽  
Motor Impairment ◽  
Mri Study

Long-term cognitive impairment of breast cancer patients after chemotherapy: A functional MRI study

2016 ◽  
Vol 85 (6) ◽  
pp. 1053-1057 ◽  
Author(s):  
Hui Miao ◽  
Jingjing Li ◽  
Sheng Hu ◽  
Xiaoxuan He ◽  
Savannah C. Partridge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Cancer Patients ◽  
Functional Mri ◽  
Breast Cancer Patients ◽  
Mri Study

Associative encoding deficits in amnestic mild cognitive impairment: A volumetric and functional MRI study

NeuroImage ◽  
2011 ◽  
Vol 56 (3) ◽  
pp. 1743-1748 ◽  
Author(s):  
Bernard Hanseeuw ◽  
Laurence Dricot ◽  
Martin Kavec ◽  
Cecile Grandin ◽  
Xavier Seron ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Amnestic Mild Cognitive Impairment ◽  
Mri Study

scholarly journals A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis

2021 ◽  
Author(s):  
Danka Jandric ◽  
Anisha Doshi ◽  
Richelle Scott ◽  
David Paling ◽  
David Rog ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Narrative Synthesis ◽  
Clear Link ◽  
Study Methodology ◽  
Definition Of ◽  
Substantial Heterogeneity

Cognitive impairment is common in multiple sclerosis (MS) and resting state functional MRI (rs-fMRI) functional connectivity (FC) is increasingly used to study its pathophysiology. However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology. Embase, Medline and PsycINFO were searched for studies assessing cognitive function and rs-fMRI FC in adults with MS. Fifty-seven studies were included in a narrative synthesis. Of these, 50 found an association between cognitive impairment and FC abnormalities. Worse cognition was linked to high FC in 18 studies, and to low FC in 17 studies. Nine studies found patterns of both high and low FC related to poor cognitive performance, in different regions or for different MR metrics. There was no clear link to increased FC during early stages of MS and reduced FC in later stages, as predicted by common models of MS pathology. Throughout, we found substantial heterogeneity in study methodology, and carefully consider how this may impact on the observed findings. These results indicate an urgent need for greater standardisation in the field, in the choice of MRI analysis and the definition of cognitive impairment. Through this we will be closer to using rsfMRI FC as a biomarker in clinical studies, and as a tool to understand mechanisms underpinning cognitive symptoms in MS.

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