scholarly journals Striatal and extrastriatal dysfunction in Parkinson’s disease with dementia: a 6‐[18F]fluoro‐l‐dopa PET study

Brain ◽  
2002 ◽  
Vol 125 (6) ◽  
pp. 1358-1365 ◽  
Author(s):  
Kengo Ito ◽  
Atsuko Nagano‐Saito ◽  
Takashi Kato ◽  
Yutaka Arahata ◽  
Akinori Nakamura ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Parkinson’S Disease With Dementia

Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia

2009 ◽  
Vol 24 (12) ◽  
pp. 1740-1746 ◽  
Author(s):  
Cristina Sanchez-Castaneda ◽  
Ramon Rene ◽  
Blanca Ramirez-Ruiz ◽  
Jaume Campdelacreu ◽  
Jordi Gascon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Cognitive Deficits ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Parkinson’S Disease With Dementia

P3-195: A TAU CLEAVAGE PRODUCT, ΔTAU314, IS INCREASED IN ALZHEIMER'S DISEASE AND PARKINSON'S DISEASE WITH DEMENTIA

2006 ◽  
Vol 14 (7S_Part_21) ◽  
pp. P1141-P1142
Author(s):  
Benjamin R. Smith ◽  
Kathryn Nelson ◽  
Peng Liu ◽  
Margaret E. Flanagan ◽  
Dirk Keene ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Cleavage Product ◽  
Parkinson’S Disease With Dementia ◽  
Tau Cleavage

scholarly journals The Role of NOX4 in Parkinson’s Disease with Dementia

2019 ◽  
Vol 20 (3) ◽  
pp. 696 ◽  
Author(s):  
Dong-Hee Choi ◽  
In-Ae Choi ◽  
Cheol Lee ◽  
Ji Yun ◽  
Jongmin Lee
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Alpha Synuclein ◽  
Cognitive Status ◽  
Dopamine Neurons ◽  
Parkinson’S Disease With Dementia ◽  
6 Hydroxydopamine ◽  
Nigrostriatal Dopamine Neurons

The neuropathology of Parkinson’s disease with dementia (PDD) has been reported to involve heterogeneous and various disease mechanisms. Alpha-synuclein (α-syn) and amyloid beta (Aβ) pathology are associated with the cognitive status of PDD, and NADPH oxidase (NOX) is known to affect a variety of cognitive functions. We investigated the effects of NOX on cognitive impairment and on α-syn and Aβ expression and aggregation in PDD. In the 6-hydroxydopamine (6-OHDA)-injected mouse model, cognitive and motor function, and the levels of α-syn, Aβ, and oligomer A11 after inhibition of NOX4 expression in the hippocampal dentate gyrus (DG) were measured by the Morris water maze, novel object recognition, rotation, and rotarod tests, as well as immunoblotting and immunohistochemistry. After 6-OHDA administration, the death of nigrostriatal dopamine neurons and the expression of α-syn and NOX1 in the substantia nigra were increased, and phosphorylated α-syn, Aβ, oligomer A11, and NOX4 were upregulated in the hippocampus. 6-OHDA dose-dependent cognitive impairment was observed, and the increased cognitive impairment, Aβ expression, and oligomer A11 production in 6-OHDA-treated mice were suppressed by NOX4 knockdown in the hippocampal DG. Our results suggest that increased expression of NOX4 in the hippocampal DG in the 6-OHDA-treated mouse induces Aβ expression and oligomer A11 production, thereby reducing cognitive function.

Increased temporal blood flow associated with visual hallucinations in Parkinson's disease with dementia

2008 ◽  
Vol 23 (3) ◽  
pp. 464-465 ◽  
Author(s):  
Hiroshi Kataoka ◽  
Yoshiko Furiya ◽  
Masami Morikawa ◽  
Satoshi Ueno ◽  
Makoto Inoue
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Visual Hallucinations ◽  
Parkinson’S Disease With Dementia
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