scholarly journals Erratum to: Reply: Broca’s area: why was neurosurgery neglected for so long when seeking to re-establish the scientific truth? and Where is the speech production area? Evidence from direct cortical electrical stimulation mapping

Brain ◽  
2021 ◽  
Author(s):  
Diego L Lorca-Puls ◽  
Andrea Gajardo-Vidal ◽  
David W Green ◽  
Cathy J Price
Keyword(s):  
Electrical Stimulation ◽  
Speech Production ◽  
Broca’S Area ◽  
Broca's Area ◽  
Production Area ◽  
Cortical Electrical Stimulation ◽  
Scientific Truth

The frame/content theory of evolution of speech production

1998 ◽  
Vol 21 (4) ◽  
pp. 499-511 ◽  
Author(s):  
Peter F. MacNeilage
Keyword(s):  
Speech Production ◽  
Vocal Communication ◽  
Vocal Learning ◽  
General Purpose ◽  
External Input ◽  
Anterior Cingulate ◽  
Broca’S Area ◽  
Broca's Area ◽  
Theory Of Evolution ◽  
Species Specific

The species-specific organizational property of speech is a continual mouth open-close alternation, the two phases of which are subject to continual articulatory modulation. The cycle constitutes the syllable, and the open and closed phases are segments – vowels and consonants, respectively. The fact that segmental serial ordering errors in normal adults obey syllable structure constraints suggests that syllabic “frames” and segmental “content” elements are separately controlled in the speech production process. The frames may derive from cycles of mandibular oscillation present in humans from babbling onset, which are responsible for the open-close alternation. These communication- related frames perhaps first evolved when the ingestion-related cyclicities of mandibular oscillation (associated with mastication [chewing] sucking and licking) took on communicative significance as lipsmacks, tonguesmacks, and teeth chatters – displays that are prominent in many nonhuman primates. The new role of Broca's area and its surround in human vocal communication may have derived from its evolutionary history as the main cortical center for the control of ingestive processes. The frame and content components of speech may have subsequently evolved separate realizations within two general purpose primate motor control systems: (1) a motivation-related medial “intrinsic” system, including anterior cingulate cortex and the supplementary motor area, for self-generated behavior, formerly responsible for ancestral vocalization control and now also responsible for frames, and (2) a lateral “extrinsic” system, including Broca's area and surround, and Wernicke's area, specialized for response to external input (and therefore the emergent vocal learning capacity) and more responsible for content.

scholarly journals From Phonemes to Articulatory Codes: An fMRI Study of the Role of Broca's Area in Speech Production

2009 ◽  
Vol 19 (9) ◽  
pp. 2156-2165 ◽  
Author(s):  
Marina Papoutsi ◽  
Jacco A. de Zwart ◽  
J. Martijn Jansma ◽  
Martin J. Pickering ◽  
James A. Bednar ◽  
...  
Keyword(s):  
Speech Production ◽  
Broca’S Area ◽  
Broca's Area ◽  
Fmri Study

scholarly journals Intraoperative subcortical mapping of a language-associated deep frontal tract connecting the superior frontal gyrus to Broca's area in the dominant hemisphere of patients with glioma

2015 ◽  
Vol 122 (6) ◽  
pp. 1390-1396 ◽  
Author(s):  
Masazumi Fujii ◽  
Satoshi Maesawa ◽  
Kazuya Motomura ◽  
Miyako Futamura ◽  
Yuichiro Hayashi ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
White Matter ◽  
Frontal Lobe ◽  
Navigation System ◽  
Broca’S Area ◽  
Language Function ◽  
Broca's Area ◽  
Mr Images ◽  
Language Functions ◽  
Subcortical Mapping

OBJECT The deep frontal pathway connecting the superior frontal gyrus to Broca's area, recently named the frontal aslant tract (FAT), is assumed to be associated with language functions, especially speech initiation and spontaneity. Injury to the deep frontal lobe is known to cause aphasia that mimics the aphasia caused by damage to the supplementary motor area. Although fiber dissection and tractography have revealed the existence of the tract, little is known about its function. The aim of this study was to determine the function of the FAT via electrical stimulation in patients with glioma who underwent awake surgery. METHODS The authors analyzed the data from subcortical mapping with electrical stimulation in 5 consecutive cases (3 males and 2 females, age range 40–54 years) with gliomas in the left frontal lobe. Diffusion tensor imaging (DTI) and tractography of the FAT were performed in all cases. A navigation system and intraoperative MRI were used in all cases. During the awake phase of the surgery, cortical mapping was performed to find the precentral gyrus and Broca's area, followed by tumor resection. After the cortical layer was removed, subcortical mapping was performed to assess language-associated fibers in the white matter. RESULTS In all 5 cases, positive responses were obtained at the stimulation sites in the subcortical area adjacent to the FAT, which was visualized by the navigation system. Speech arrest was observed in 4 cases, and remarkably slow speech and conversation was observed in 1 case. The location of these sites was also determined on intraoperative MR images and estimated on preoperative MR images with DTI tractography, confirming the spatial relationships among the stimulation sites and white matter tracts. Tumor removal was successfully performed without damage to this tract, and language function did not deteriorate in any of the cases postoperatively. CONCLUSIONS The authors identified the left FAT and confirmed that it was associated with language functions. This tract should be recognized by clinicians to preserve language function during brain tumor surgery, especially for tumors located in the deep frontal lobe on the language-dominant side.

scholarly journals A focal brain-cooling device as an alternative to electrical stimulation for language mapping during awake craniotomy: patient series

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Sadahiro Nomura ◽  
Takao Inoue ◽  
Hirochika Imoto ◽  
Hirokazu Sadahiro ◽  
Kazutaka Sugimoto ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Functional Mapping ◽  
Awake Craniotomy ◽  
Mapping Technique ◽  
Broca’S Area ◽  
Brain Cooling ◽  
Broca's Area ◽  
Cooling Device ◽  
Language Mapping ◽  
Patient Series

BACKGROUND Functional mapping in awake craniotomy has the potential risk of electrical stimulation-related seizure. The authors have developed a novel mapping technique using a brain-cooling device. The cooling probe is cylindrical in shape with a thermoelectric cooling plate (10 × 10 mm) at the bottom. A proportional integration and differentiation-controlled system adjusts the temperature accurately (Japan patent no. P5688666). The authors used it in two patients with glioblastoma. Broca’s area was identified by electrical stimulation, and then the cooling probe set at 5°C was attempted on it. OBSERVATIONS Electrocorticogram was suppressed, and the temperature dropped to 8°C in 50 sec. A positive aphasic reaction was reproduced on Broca’s area at a latency of 7 sec. A negative reaction appeared on the adjacent cortices despite the temperature decrease. The sensitivity and specificity were 60% and 100%, respectively. No seizures or other adverse events related to the cooling were recognized, and no histological damage to the cooled cortex was observed. LESSONS The cooling probe suppressed topographical brain function selectively and reversibly. Awake functional mapping based on thermal neuromodulation technology could substitute or compensate for the conventional electrical mapping.

Comprehension deficits elicited by electrical stimulation of Broca's area

Brain ◽  
1993 ◽  
Vol 116 (3) ◽  
pp. 695-715 ◽  
Author(s):  
Leonard Schäffler ◽  
Hans O. Lüders ◽  
Dudley S. Dinner ◽  
Ronald P. Lesser ◽  
Gordon J. Chelune
Keyword(s):  
Electrical Stimulation ◽  
Broca’S Area ◽  
Broca's Area ◽  
Stimulation Of

scholarly journals Brain regions that support accurate speech production after damage to Broca’s area

2021 ◽  
Author(s):  
Diego L Lorca-Puls ◽  
Andrea Gajardo-Vidal ◽  
Ploras Team ◽  
Marion Oberhuber ◽  
Susan Prejawa ◽  
...  
Keyword(s):  
Speech Production ◽  
Brain Activation ◽  
Broca’S Area ◽  
Broca's Area ◽  
Wide Range ◽  
Pars Opercularis ◽  
Crus I ◽  
The Right ◽  
Overt Speech ◽  
Neurologically Intact

Abstract By combining functional neuroimaging and a wide range of tasks that place varying demands on speech production, Lorca-Puls et al. reveal that right cerebellar Crus I and right pars opercularis are likely to play a particularly important role in supporting successful speech production following damage to Broca’s area. Broca’s area in the posterior half of the left inferior frontal gyrus has traditionally been considered an important node in the speech production network. Nevertheless, recovery of speech production has been reported, to different degrees, within a few months of damage to Broca’s area. Importantly, contemporary evidence suggests that, within Broca’s area, its posterior part (i.e. pars opercularis) plays a more prominent role in speech production than its anterior part (i.e. pars triangularis). In the current study, we therefore investigated the brain activation patterns that underlie accurate speech production following stroke damage to the opercular part of Broca’s area. By combining functional MRI and 13 tasks that place varying demands on speech production, brain activation was compared in (i) seven patients of interest with damage to the opercular part of Broca’s area, (ii) 55 neurologically-intact controls and (iii) 28 patient controls with left-hemisphere damage that spared Broca’s area. When producing accurate overt speech responses, the patients with damage to the left pars opercularis activated a substantial portion of the normal bilaterally distributed system. Within this system, there was a lesion-site-dependent effect in a specific part of the right cerebellar Crus I where activation was significantly higher in the patients with damage to the left pars opercularis compared to both neurologically-intact and patient controls. In addition, activation in the right pars opercularis was significantly higher in the patients with damage to the left pars opercularis relative to neurologically-intact controls but not patient controls (after adjusting for differences in lesion size). By further examining how right Crus I and right pars opercularis responded across a range of conditions in the neurologically-intact controls, we suggest that these regions play distinct roles in domain-general cognitive control. Finally, we show that enhanced activation in the right pars opercularis cannot be explained by release from an inhibitory relationship with the left pars opercularis (i.e. dis-inhibition) because right pars opercularis activation was positively related to left pars opercularis activation in neurologically-intact controls. Our findings motivate and guide future studies to investigate (a) how exactly right Crus I and right pars opercularis support accurate speech production after damage to the opercular part of Broca’s area and (b) whether non-invasive neurostimulation to one or both of these regions boosts speech production recovery after damage to the opercular part of Broca’s area.

Electrical stimulation mapping of nouns and verbs in Broca’s area

2015 ◽  
Vol 145-146 ◽  
pp. 53-63 ◽  
Author(s):  
Viktória Havas ◽  
Andreu Gabarrós ◽  
Montserrat Juncadella ◽  
Xavi Rifa-Ros ◽  
Gerard Plans ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Broca’S Area ◽  
Broca's Area
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