Comprehension deficits elicited by electrical stimulation of Broca's area

Brain ◽  
1993 ◽  
Vol 116 (3) ◽  
pp. 695-715 ◽  
Author(s):  
Leonard Schäffler ◽  
Hans O. Lüders ◽  
Dudley S. Dinner ◽  
Ronald P. Lesser ◽  
Gordon J. Chelune
Keyword(s):  
Electrical Stimulation ◽  
Broca’S Area ◽  
Broca's Area ◽  
Stimulation Of

scholarly journals Intraoperative subcortical mapping of a language-associated deep frontal tract connecting the superior frontal gyrus to Broca's area in the dominant hemisphere of patients with glioma

2015 ◽  
Vol 122 (6) ◽  
pp. 1390-1396 ◽  
Author(s):  
Masazumi Fujii ◽  
Satoshi Maesawa ◽  
Kazuya Motomura ◽  
Miyako Futamura ◽  
Yuichiro Hayashi ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
White Matter ◽  
Frontal Lobe ◽  
Navigation System ◽  
Broca’S Area ◽  
Language Function ◽  
Broca's Area ◽  
Mr Images ◽  
Language Functions ◽  
Subcortical Mapping

OBJECT The deep frontal pathway connecting the superior frontal gyrus to Broca's area, recently named the frontal aslant tract (FAT), is assumed to be associated with language functions, especially speech initiation and spontaneity. Injury to the deep frontal lobe is known to cause aphasia that mimics the aphasia caused by damage to the supplementary motor area. Although fiber dissection and tractography have revealed the existence of the tract, little is known about its function. The aim of this study was to determine the function of the FAT via electrical stimulation in patients with glioma who underwent awake surgery. METHODS The authors analyzed the data from subcortical mapping with electrical stimulation in 5 consecutive cases (3 males and 2 females, age range 40–54 years) with gliomas in the left frontal lobe. Diffusion tensor imaging (DTI) and tractography of the FAT were performed in all cases. A navigation system and intraoperative MRI were used in all cases. During the awake phase of the surgery, cortical mapping was performed to find the precentral gyrus and Broca's area, followed by tumor resection. After the cortical layer was removed, subcortical mapping was performed to assess language-associated fibers in the white matter. RESULTS In all 5 cases, positive responses were obtained at the stimulation sites in the subcortical area adjacent to the FAT, which was visualized by the navigation system. Speech arrest was observed in 4 cases, and remarkably slow speech and conversation was observed in 1 case. The location of these sites was also determined on intraoperative MR images and estimated on preoperative MR images with DTI tractography, confirming the spatial relationships among the stimulation sites and white matter tracts. Tumor removal was successfully performed without damage to this tract, and language function did not deteriorate in any of the cases postoperatively. CONCLUSIONS The authors identified the left FAT and confirmed that it was associated with language functions. This tract should be recognized by clinicians to preserve language function during brain tumor surgery, especially for tumors located in the deep frontal lobe on the language-dominant side.

scholarly journals A focal brain-cooling device as an alternative to electrical stimulation for language mapping during awake craniotomy: patient series

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Sadahiro Nomura ◽  
Takao Inoue ◽  
Hirochika Imoto ◽  
Hirokazu Sadahiro ◽  
Kazutaka Sugimoto ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Functional Mapping ◽  
Awake Craniotomy ◽  
Mapping Technique ◽  
Broca’S Area ◽  
Brain Cooling ◽  
Broca's Area ◽  
Cooling Device ◽  
Language Mapping ◽  
Patient Series

BACKGROUND Functional mapping in awake craniotomy has the potential risk of electrical stimulation-related seizure. The authors have developed a novel mapping technique using a brain-cooling device. The cooling probe is cylindrical in shape with a thermoelectric cooling plate (10 × 10 mm) at the bottom. A proportional integration and differentiation-controlled system adjusts the temperature accurately (Japan patent no. P5688666). The authors used it in two patients with glioblastoma. Broca’s area was identified by electrical stimulation, and then the cooling probe set at 5°C was attempted on it. OBSERVATIONS Electrocorticogram was suppressed, and the temperature dropped to 8°C in 50 sec. A positive aphasic reaction was reproduced on Broca’s area at a latency of 7 sec. A negative reaction appeared on the adjacent cortices despite the temperature decrease. The sensitivity and specificity were 60% and 100%, respectively. No seizures or other adverse events related to the cooling were recognized, and no histological damage to the cooled cortex was observed. LESSONS The cooling probe suppressed topographical brain function selectively and reversibly. Awake functional mapping based on thermal neuromodulation technology could substitute or compensate for the conventional electrical mapping.

Transcranial magnetic stimulation-evoked potentials after the stimulation of the right-hemispheric homologue of Broca’s area

Neuroreport ◽  
2019 ◽  
Vol 30 (16) ◽  
pp. 1110-1114
Author(s):  
Karita S.-T. Salo ◽  
Selja M.I. Vaalto ◽  
Pantelis Lioumis ◽  
Risto J. Ilmoniemi
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Evoked Potentials ◽  
Magnetic Stimulation ◽  
Broca’S Area ◽  
Broca's Area ◽  
The Right ◽  
Stimulation Of

Electrical stimulation mapping of nouns and verbs in Broca’s area

2015 ◽  
Vol 145-146 ◽  
pp. 53-63 ◽  
Author(s):  
Viktória Havas ◽  
Andreu Gabarrós ◽  
Montserrat Juncadella ◽  
Xavi Rifa-Ros ◽  
Gerard Plans ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Broca’S Area ◽  
Broca's Area

scholarly journals Selective Priming of Syntactic Processing by Event-Related Transcranial Magnetic Stimulation of Broca's Area

Neuron ◽  
2002 ◽  
Vol 35 (6) ◽  
pp. 1177-1182 ◽  
Author(s):  
Kuniyoshi L Sakai ◽  
Yasuki Noguchi ◽  
Tatsuya Takeuchi ◽  
Eiju Watanabe
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Syntactic Processing ◽  
Broca’S Area ◽  
Broca's Area ◽  
Stimulation Of
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