scholarly journals Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal

Brain ◽  
2001 ◽  
Vol 124 (5) ◽  
pp. 893-906 ◽  
Author(s):  
G. M. O'Hanlon
Keyword(s):  
Nerve Terminal ◽  
Motor Nerve ◽  
Motor Nerve Terminal ◽  
Ganglioside Antibodies ◽  
Gq1b Ganglioside

Motor nerve terminal loss from degenerating muscle fibers

Neuron ◽  
1989 ◽  
Vol 3 (6) ◽  
pp. 677-688 ◽  
Author(s):  
Mark Rich ◽  
Jeff W. Lichtman
Keyword(s):  
Nerve Terminal ◽  
Motor Nerve ◽  
Muscle Fibers ◽  
Motor Nerve Terminal

Motor nerve terminal morphologic plasticity induced by small changes in the locomotor activtty of the adult rat

1990 ◽  
Vol 14 ◽  
pp. 227
Author(s):  
J TOMAS ◽  
R FENOLL ◽  
J BATLLE ◽  
M SANTAFE ◽  
V PIERA ◽  
...  
Keyword(s):  
Nerve Terminal ◽  
Motor Nerve ◽  
Motor Nerve Terminal ◽  
Adult Rat

scholarly journals Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. I. Ultrastructural autoradiographic localization and quantitation of distinct membrane acceptors for types A and B on motor nerves.

1986 ◽  
Vol 103 (2) ◽  
pp. 521-534 ◽  
Author(s):  
J D Black ◽  
J O Dolly
Keyword(s):  
Plasma Membrane ◽  
Neuromuscular Junction ◽  
Nerve Terminal ◽  
Motor Nerve ◽  
Type A ◽  
Nerve Trunk ◽  
Metabolic Inhibitors ◽  
Motor Nerve Terminal ◽  
Electron Microscopic Autoradiography

The labeling patterns produced by radioiodinated botulinum neurotoxin (125I-BoNT) types A and B at the vertebrate neuromuscular junction were investigated using electron microscopic autoradiography. The data obtained allow the following conclusions to be made. 125I-BoNT type A, applied in vivo or in vitro to mouse diaphragm or frog cutaneous pectoris muscle, interacts saturably with the motor nerve terminal only; silver grains occur on the plasma membrane, within the synaptic bouton, and in the axoplasm of the nerve trunk, suggesting internalization and retrograde intra-axonal transport of toxin or fragments thereof. 125I-BoNT type B, applied in vitro to the murine neuromuscular junction, interacts likewise with the motor nerve terminal except that a lower proportion of internalized radioactivity is seen. This result is reconcilable with the similar, but not identical, pharmacological action of these toxin types. The saturability of labeling in each case suggested the involvement of acceptors; on preventing the internalization step with metabolic inhibitors, their precise location became apparent. They were found on all unmyelinated areas of the nerve terminal membrane, including the preterminal axon and the synaptic bouton. Although 125I-BoNT type A interacts specifically with developing terminals of newborn rats, the unmyelinated plasma membrane of the nerve trunk is not labeled, indicating that the acceptors are unique components restricted to the nerve terminal area. BoNT types A and B have distinct acceptors on the terminal membrane. Having optimized the conditions for saturation of these binding sites and calibrated the autoradiographic procedure, we found the densities of the acceptors for types A and B to be approximately 150 and 630/micron 2 of membrane, respectively. It is proposed that these membrane acceptors target BoNT to the nerve terminal and mediate its delivery to an intracellular site, thus contributing to the toxin's selective inhibitory action on neurotransmitter release.

Bursts of miniature end-plate potentials can be released from localized regions of the frog motor nerve terminal

1981 ◽  
Vol 221 (2) ◽  
pp. 382-386 ◽  
Author(s):  
Ira S. Cohen ◽  
William Van Der Kloot ◽  
Stuart B. Barton
Keyword(s):  
Nerve Terminal ◽  
Motor Nerve ◽  
Motor Nerve Terminal ◽  
End Plate

scholarly journals The Frog Motor Nerve Terminal Has Very Brief Action Potentials and Three Electrical Regions Predicted to Differentially Control Transmitter Release

2020 ◽  
Vol 40 (18) ◽  
pp. 3504-3516 ◽  
Author(s):  
Scott P. Ginebaugh ◽  
Eric D. Cyphers ◽  
Viswanath Lanka ◽  
Gloria Ortiz ◽  
Evan W. Miller ◽  
...  
Keyword(s):  
Nerve Terminal ◽  
Transmitter Release ◽  
Action Potentials ◽  
Motor Nerve ◽  
Motor Nerve Terminal
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