scholarly journals Recirculatory model of fentanyl disposition with the brain as the target organ

2004 ◽  
Vol 93 (5) ◽  
pp. 687-697 ◽  
Author(s):  
R.N. Upton ◽  
C. Grant ◽  
A.M. Martinez ◽  
G.L. Ludbrook
Keyword(s):  
Target Organ ◽  
Recirculatory Model ◽  
The Brain

The brain as a target organ of gonadal steroids

1992 ◽  
Vol 17 (4) ◽  
pp. 385-390 ◽  
Author(s):  
A.R. Genazzani ◽  
M. Gastaldi ◽  
B. Bidzinska ◽  
N. Mercuri ◽  
A.D. Genazzani ◽  
...  
Keyword(s):  
Target Organ ◽  
Gonadal Steroids ◽  
The Brain

The brain is a target organ after acute exposure to depleted uranium

Toxicology ◽  
2005 ◽  
Vol 212 (2-3) ◽  
pp. 219-226 ◽  
Author(s):  
P. Lestaevel ◽  
P. Houpert ◽  
C. Bussy ◽  
B. Dhieux ◽  
P. Gourmelon ◽  
...  
Keyword(s):  
Depleted Uranium ◽  
Target Organ ◽  
Acute Exposure ◽  
The Brain

Neurotoxicity of manganese in the teleost Tilapia

1990 ◽  
Vol 48 (3) ◽  
pp. 828-829
Author(s):  
Annabelle A. Herrera ◽  
Elena S. Catap
Keyword(s):  
Essential Element ◽  
Target Organ ◽  
State University ◽  
Manganese Exposure ◽  
Organ Systems ◽  
The Central Nervous System ◽  
Steel Industries ◽  
Metal Dust ◽  
The Brain ◽  
Manganese Poisoning

Manganese is considered as an essential element for man and other animals. Although it is one of the trace elements least toxic to mammals, man-made pollution related to the steel industries and exposure to the mining of manganese ore represent potential hazards to organisms in these areas.One of the target organ systems of manganese is the central nervous system (Beliles, 1975). Intake of its metal dust can lead to chronic manganese poisoning resembling Parkinson’s disease (Ferraz, et.al., 1988). Symptoms of this disease have been observed in human after prolonged chronic exposure to manganese (Scheuhammer and Cherian, 1981).Studies being reported on manganese deal with mammals and are focused on its neurotoxicity, most of which are based on physiological and neurochemical mechanisms. There has been no report yet of morphological or ultrastructural abnormalities associated with manganese exposure. In this study, the effects of manganese on the morphology and ultrastructure of the brain of Tilapia finger lings will be discussed.Tilapia fingerlings from Central Luzon State University, Muñoz, Nueva Ecija were acclimated prior to MnCl2 exposure.

scholarly journals Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease

2006 ◽  
Vol 19 (1) ◽  
pp. 80-94 ◽  
Author(s):  
Robert S. Fujinami ◽  
Matthias G. von Herrath ◽  
Urs Christen ◽  
J. Lindsay Whitton
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Virus Infection ◽  
Molecular Mimicry ◽  
Viral Persistence ◽  
Target Organ ◽  
Virus Infections ◽  
Epitope Spreading ◽  
Bystander Activation ◽  
The Brain

SUMMARY Virus infections and autoimmune disease have long been linked. These infections often precede the occurrence of inflammation in the target organ. Several mechanisms often used to explain the association of autoimmunity and virus infection are molecular mimicry, bystander activation (with or without epitope spreading), and viral persistance. These mechanisms have been used separately or in various combinations to account for the immunopathology observed at the site of infection and/or sites of autoimmune disease, such as the brain, heart, and pancreas. These mechanisms are discussed in the context of multiple sclerosis, myocarditis, and diabetes, three immune-medicated diseases often linked with virus infections.

scholarly journals Silent cerebral infarction as a form of hypertensive target organ damage in the brain.

Hypertension ◽  
1992 ◽  
Vol 20 (6) ◽  
pp. 816-820 ◽  
Author(s):  
H Hougaku ◽  
M Matsumoto ◽  
K Kitagawa ◽  
K Harada ◽  
N Oku ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Silent Cerebral Infarction ◽  
The Brain

Cardio-respiratory reanimation: The brain is the target organ

2010 ◽  
Vol 21 (1) ◽  
pp. 50-51 ◽  
Author(s):  
Calixto Machado ◽  
Jesus Pérez-Nellar ◽  
Claudio Scherle ◽  
Alejandro Pando ◽  
Julius Korein
Keyword(s):  
Target Organ ◽  
The Brain
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