scholarly journals Bioinformatics tools for the structural elucidation of multi-subunit protein complexes by mass spectrometric analysis of protein-protein cross-links

2011 ◽  
Vol 12 (6) ◽  
pp. 660-671 ◽  
Author(s):  
S. L. N. Mayne ◽  
H.-G. Patterton
Keyword(s):  
Protein Complexes ◽  
Structural Elucidation ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Subunit Protein ◽  
Bioinformatics Tools ◽  
Cross Links

Computer-assisted mass spectrometric analysis of naturally occurring and artificially introduced cross-links in proteins and protein complexes

FEBS Journal ◽  
2006 ◽  
Vol 273 (2) ◽  
pp. 281-291 ◽  
Author(s):  
Leo J. Koning ◽  
Piotr T. Kasper ◽  
Jaap Willem Back ◽  
Merel A. Nessen ◽  
Frank Vanrobaeys ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Computer Assisted ◽  
Naturally Occurring ◽  
Cross Links

A new crosslinker for mass spectrometric analysis of the quaternary structure of protein complexes

2001 ◽  
Vol 12 (2) ◽  
pp. 222-227 ◽  
Author(s):  
J. W. Back ◽  
A. F. Hartog ◽  
H. L. Dekker ◽  
Anton O. Muijsers ◽  
L. J. Koning ◽  
...  
Keyword(s):  
Quaternary Structure ◽  
Protein Complexes ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis

scholarly journals SECAT: Quantifying differential protein-protein interaction states by network-centric analysis

2019 ◽  
Author(s):  
George Rosenberger ◽  
Moritz Heusel ◽  
Isabell Bludau ◽  
Ben Collins ◽  
Claudia Martelli ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Protein Interactions ◽  
Molecular Mechanisms ◽  
Protein Complexes ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Size Exclusion ◽  
Spectrometric Analysis ◽  
Differential Analysis ◽  
Ppi Networks

AbstractProtein-protein interactions (PPIs) play critical functional and regulatory roles in virtually all cellular processes. They are essential for the formation of macromolecular complexes, which in turn constitute the basis for extended protein interaction networks that determine the functional state of a cell. We and others have previously shown that chromatographic fractionation of native protein complexes in combination with bottom-up mass spectrometric analysis of consecutive fractions supports the multiplexed characterization and detection of state-specific changes of protein complexes.In this study, we describe a computational approach that extends the analysis of data from the co-fractionation / mass spectrometric analysis of native complexes to the level of PPI networks, thus enabling a qualitative and quantitative comparison of the proteome organization between samples and states. The Size-Exclusion Chromatography Algorithmic Toolkit (SECAT) implements a novel, network-centric strategy for the scalable and robust differential analysis of PPI networks. SECAT and its underlying statistical framework elucidate differential quantitative abundance and stoichiometry attributes of proteins in the context of their PPIs. We validate algorithm predictions using publicly available datasets and demonstrate that SECAT represents a more scalable and effective methodology to assess protein-network state and that our approach thus obviates the need to explicitly infer individual protein complexes. Further, by differential analysis of PPI networks of HeLa cells in interphase and mitotic state, respectively, we demonstrate the ability of the algorithm to detect PPI network differences and to thus suggest molecular mechanisms that differentiate cellular states.

scholarly journals 7-Bromo-1-ethyl-β-carboline, an Alkaloid from the New Zealand Marine Bryozoan Pterocella vesiculosa

2013 ◽  
Vol 8 (6) ◽  
pp. 1934578X1300800
Author(s):  
Michèle R. Prinsep ◽  
Mérine Dumté
Keyword(s):  
New Zealand ◽  
Structural Elucidation ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Marine Bryozoan

A new alkaloid, 7-bromo-1-ethyl-β-carboline (1) has been isolated from the New Zealand marine bryozoan Pterocella vesiculosa (Lamarck, 1816). Structural elucidation was achieved through NMR spectroscopic and mass spectrometric analysis.

scholarly journals Lipids of human meibum: mass-spectrometric analysis and structural elucidation

2007 ◽  
Vol 48 (10) ◽  
pp. 2220-2235 ◽  
Author(s):  
Igor A. Butovich ◽  
Eduardo Uchiyama ◽  
James P. McCulley
Keyword(s):  
Structural Elucidation ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis

A Questionnaire Survey on General Status and Opinions about Clinical Mass Spectrometric Analysis in Korea (2018)

2019 ◽  
Vol 9 (3) ◽  
pp. 161
Author(s):  
Sung-Eun Cho ◽  
Hyojin Chae ◽  
Hyung-Doo Park ◽  
Sail Chun ◽  
Yong-Wha Lee ◽  
...  
Keyword(s):  
Questionnaire Survey ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
General Status

Mechanisms of Dopant Depth Profile Modification During Mass Spectrometric Analysis of Multilayer Structure

2015 ◽  
Vol 60 (6) ◽  
pp. 511-520 ◽  
Author(s):  
A.A. Efremov ◽  
◽  
V.G. Litovchenko ◽  
V.P. Melnik ◽  
O.S. Oberemok ◽  
...  
Keyword(s):  
Depth Profile ◽  
Multilayer Structure ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Profile Modification

Mass Spectrometric Analysis of Porcine Rhodopsin¶

2002 ◽  
Vol 75 (3) ◽  
pp. 316 ◽  
Author(s):  
Zsolt Ablonczy ◽  
Patrice Goletz ◽  
Daniel R. Knapp ◽  
Rosalie K. Crouch
Keyword(s):  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis
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