scholarly journals Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colorectal cancer at high risk for the development of peritoneal metastases. A matched case-control study

2015 ◽  
Vol 26 ◽  
pp. vi42
Author(s):  
D. Baratti ◽  
S. Kusamura ◽  
F. Pietrantonio ◽  
M. Guaglio ◽  
R. Berenato ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Intraperitoneal Chemotherapy ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Case Control Study ◽  
Case Control ◽  
Peritoneal Metastases ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Drinking Water Source, Chlorinated Water, and Colorectal Cancer: A Matched Case-Control Study in Ethiopia

2022 ◽  
Vol 16 ◽  
pp. 117863022110644
Author(s):  
Nebiyou Tafesse ◽  
Massimiliano Porcelli ◽  
Sirak Robele Gari ◽  
Argaw Ambelu
Keyword(s):  
Colorectal Cancer ◽  
Drinking Water ◽  
Case Control Study ◽  
Tap Water ◽  
Addis Ababa ◽  
Case Control ◽  
Matched Case ◽  
Stratified Analysis ◽  
Matched Case Control Study ◽  
Control Study

Background: There is no study conducted on the association between disinfection byproducts (DBPs) in chlorinated drinking water and colorectal cancer (CRC) in Ethiopia. Therefore, this study aimed to determine the relation between chlorine based DBPs in drinking water and CRC in Addis Ababa, Ethiopia. Methods: A facility based matched case control study was conducted involving 224 cases and 448 population controls from June 2020 to May 2021. Cases were defined as histologically confirmed CRC cases. Cases were matched with controls by residence, age, and sex using frequency and individual matching. Geocoding of cases, health facility, and georeferencing of controls were carried out. Data was collected using a pretested structured questionnaire. Pearson Chi square and Fisher’s exact tests were employed to assess associations. Stratified analysis was used to detect confounding factors and effect modification. A multivariable conditional logistic regression was used to identify risk factors of CRC. Results: Of 214 CRC cases, 148 (69.2%) used chlorinated water whereas out of 428 controls 161 (37.6%) used chlorinated water. In the final regression model, drinking chlorinated surface water (adjusted matched odds ratio [adjusted mOR] = 2.6; 95% CI 1.7-4.0), history of swimming (adjusted mOR = 2.4; 95% CI 1.4-4.1), years at the place of current residence (adjusted mOR = 1.5; 95% CI 1.1-2.2), hot tap water use for showering (adjusted mOR; 3.8 = 95% CI 2.5-5.9) were significantly associated with CRC. The stratified analysis confirmed that smoking and meat ingestion were not effect modifiers and confounders. Conclusion: Drinking chlorinated water for extended years is a significant risk factor for CRC in Addis Ababa, Ethiopia. In addition, hot tap water use for showering, and swimming history are risk factors for CRC. This information is essential to design integrated interventions that consider chlorination by-products and exposure routes toward the prevention and control of CRC in Ethiopia. Initiating alternative methods to chlorine disinfection of drinking water is also essential.

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