Cytoreductive surgery and HIPEC offers similar outcomes in patients with rectal peritoneal metastases compared to colon cancer patients: a matched case control study

2016 ◽  
Vol 113 (5) ◽  
pp. 548-553 ◽  
Author(s):  
Geert A. Simkens ◽  
Thijs R. van Oudheusden ◽  
Hidde J. Braam ◽  
Marinus J. Wiezer ◽  
Simon W. Nienhuijs ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Cytoreductive Surgery ◽  
Case Control Study ◽  
Case Control ◽  
Peritoneal Metastases ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989–2012: a matched case–control study

Gut ◽  
2019 ◽  
Vol 68 (11) ◽  
pp. 1971-1978 ◽  
Author(s):  
Jiajia Zhang ◽  
Charles Haines ◽  
Alastair J M Watson ◽  
Andrew R Hart ◽  
Mary Jane Platt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Case Control Study ◽  
Antibiotic Use ◽  
Case Control ◽  
Proximal Colon ◽  
Oral Antibiotic ◽  
Antibiotic Exposure ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

BackgroundMicrobiome dysbiosis predisposes to colorectal cancer (CRC), but a population-based study of oral antibiotic exposure and risk patterns is lacking.ObjectiveTo assess the association between oral antibiotic use and CRC risk.DesignA matched case–control study (incident CRC cases and up to five matched controls) was performed using the Clinical Practice Research Datalink from 1989 to 2012.Results28 980 CRC cases and 137 077 controls were identified. Oral antibiotic use was associated with CRC risk, but effects differed by anatomical location. Antibiotic use increased the risk of colon cancer in a dose-dependent fashion (ptrend <0.001). The risk was observed after minimal use, and was greatest in the proximal colon and with antibiotics with anti-anaerobic activity. In contrast, an inverse association was detected between antibiotic use and rectal cancers (ptrend=0.003), particularly with length of antibiotic exposure >60 days (adjusted OR (aOR), 0.85, 95% CI 0.79 to 0.93) as compared with no antibiotic exposure. Penicillins, particularly ampicillin/amoxicillin increased the risk of colon cancer (aOR=1.09 (1.05 to 1.13)), whereas tetracyclines reduced the risk of rectal cancer (aOR=0.90 (0.84 to 0.97)). Significant interactions were detected between antibiotic use and tumour location (colon vs rectum, pinteraction<0.001; proximal colon versus distal colon, pinteraction=0.019). The antibiotic–cancer association was found for antibiotic exposure occurring >10 years before diagnosis (aOR=1.17 (1.06 to 1.31)).ConclusionOral antibiotic use is associated with an increased risk of colon cancer but a reduced risk of rectal cancer. This effect heterogeneity may suggest differences in gut microbiota and carcinogenesis mechanisms along the lower intestinal tract.

Endometrial cancer patients and tibolone: A matched case–control study

Maturitas ◽  
2006 ◽  
Vol 55 (3) ◽  
pp. 264-269 ◽  
Author(s):  
Kwang-Beom Lee ◽  
Jong-Min Lee ◽  
Jae-Kwan Lee ◽  
Chi-Heum Cho
Keyword(s):  
Endometrial Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Standard versus Limited Colon Resection for High Risk T1 Colon Cancer. A Matched Case-Control Study

2014 ◽  
Vol 23 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Marco La Torre ◽  
Giuseppe Nigri ◽  
Federica Mazzuca ◽  
Mario Ferri ◽  
Andrea Botticelli ◽  
...  
Keyword(s):  
Colon Cancer ◽  
High Risk ◽  
Case Control Study ◽  
Case Control ◽  
Colon Resection ◽  
Colon Polyps ◽  
Segmental Colectomy ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Background & Aims: National Comprehensive Cancer Network (NCCN) recommends a colectomy in presence of high risk T1 colon polyps considering the risk of incomplete lymph node dissection or presence of residual disease. We evaluated the outcomes of segmental versus standard colon resection for high risk T1 colon cancers, in order to demonstrate if segmental colectomy (SegCR) allows same short-term and oncological results compared to standard radical colectomy (StaCR).Methods. A matched case-control study on patients who had undergone segmental versus standard colon resection was performed. One-hundred and two patients with high risk T1 colon cancer after endoscopic polypectomy, divided in 2 homogeneous groups of 51 cases, were analyzed, and intra-operative, post-operative and oncological data were compared.Results. Segmental colectomy allowed less operative time and intra-operative blood loss compared to StaCR (p < 0.001). Hospital stay after SegCR was shorter compared to StaCR (p < 0.001). No differences were found in terms of overall morbidity and mortality rates. Five-year actuarial overall, disease-free and disease-specific survival after StaCR were similar to SegCR (87%, 96% and 95% vs. 88%, 97% and 94%, respectively, p = 0.51, p=0.33, p=0.78).Conclusions. According to our findings, SegCR can be a valid alternative to StaCR for high risk T1 colon polyps. Segmental colectomy allows better peri-operative outcomes compared to StaCR ensuring the same oncological long-term outcomes.

Sign in / Sign up

Export Citation Format

Share Document