scholarly journals Sleep Duration, Kidney Function, and Their Effects on Cerebral Small Vessel Disease in Elderly Hypertensive Patients

2015 ◽  
Vol 28 (7) ◽  
pp. 884-893 ◽  
Author(s):  
M. Nagai ◽  
S. Hoshide ◽  
M. Takahashi ◽  
M. Shimpo ◽  
K. Kario
Keyword(s):  
Kidney Function ◽  
Sleep Duration ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Hypertensive Patients ◽  
Vessel Disease ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

scholarly journals Microalbuminuria and the Combination of MRI Markers of Cerebral Small Vessel Disease

2016 ◽  
Vol 42 (1-2) ◽  
pp. 66-72 ◽  
Author(s):  
Andrea Vilar-Bergua ◽  
Iolanda Riba-Llena ◽  
Natalia Ramos ◽  
Xavier Mundet ◽  
Eugenia Espinel ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Basal Ganglia ◽  
Glomerular Filtration ◽  
Kidney Function ◽  
Filtration Rate ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Perivascular Spaces ◽  
Vessel Disease

Background: Kidney function has been related to the presence of individual markers of cerebral small vessel disease (CSVD), as lacunes, white matter hyperintensities (WMH) or microbleeds. We aimed at studying the relationship of kidney dysfunction with the combination of several markers of CSVD. Methods: Subjects are those included in the ISSYS cohort (Investigating Silent Strokes in hypertensives: a magnetic resonance imaging study). A scale ranging from 0 to 4 points was applied based on the presence (one point each) of lacunes, deep microbleeds, moderate to extensive basal ganglia enlarged perivascular spaces (EPVS), and periventricular or deep WMH. We determined the creatinine-based glomerular filtration rate and the urinary albumin-to-creatinine ratio (UACR) as markers of kidney function and studied their association with the scale of CSVD in univariate and ordinal logistic regression analyses. Results: Among the 975 patients included, 28.2% presented one or more CSVD markers, being the most prevalent marker (either alone or in combination) basal ganglia EPVS. The UACR was elevated at increasing the scores of the CSVD scale and remained as independent predictor of the combination of markers (common OR per natural log unit increase in UACR: 1.23, 1.07-1.41) after controlling per age, gender, cardiovascular risk, antihypertensive treatment and hypertension duration. In contrast, no associations were found between the CSVD scores and the creatinine-based estimated glomerular filtration rate. Conclusions: A significant proportion of stroke-free hypertensives present at least one imaging marker of CSVD. UACR but not creatinine-based glomerular filtration rate is associated with the combination of markers of CSVD.

scholarly journals Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients

2019 ◽  
Vol 9 (9) ◽  
pp. 91
Author(s):  
Zenaida Milagros Hernández-Díaz ◽  
Marisol Peña-Sánchez ◽  
Alina González-Quevedo Monteagudo ◽  
Sergio González-García ◽  
Paula Andrea Arias-Cadena ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Vascular Damage ◽  
Small Vessel ◽  
Hypertensive Retinopathy ◽  
Hypertensive Patients ◽  
Lacunar Infarcts ◽  
Vessel Disease ◽  
Subclinical Vascular Damage

Background: Cerebral small vessel disease (CSVD) is frequent in patients with cardiovascular risk factors including arterial hypertension, and it is associated with vascular damage in other organs and the risk of stroke, cognitive impairment, and dementia. Early diagnosis of CSVD could prevent deleterious consequences. Objective: To characterize CSVD associated with indicators of subclinical vascular damage in asymptomatic hypertensive patients. Materials and Methods: Participants were hypertensive (HT) and non-hypertensive (non-HT) individuals; without signs of cerebrovascular disease, dementia, and chronic renal failure. For CSVD, white matter hyperintensities (WMH), enlarged Virchow–Robin perivascular spaces (EVRPS), lacunar infarcts, and microbleeds were investigated. Subclinical vascular damage was evaluated (hypertensive retinopathy, microalbuminuria, and extracranial carotid morphology: intima media thickness (IMT) and atheroma plaque). Results: CSVD MRI findings were more frequent in HT; as well as greater intimal thickening. The IMT + plaque was significantly associated with all MRI variables; but retinopathy was correlated with EVRPS and lacunar infarcts. Only microalbuminuria was related to the greater severity of WMH in HT. Multivariate analysis evidenced that CSVD was independently associated with the combination of indicators of vascular damage and systolic blood pressure. Conclusions: Combining indicators of subclinical vascular damage, such as carotid morphological variables, microalbuminuria, and hypertensive retinopathy for early detection of CSVD in asymptomatic hypertensive patients could prove to be useful to take actions for the prevention of irreversible brain damage, which could lead to cognitive impairment, dementia and stroke.

Kidney function changes and their relation with the progression of cerebral small vessel disease and cognitive decline

2020 ◽  
Vol 409 ◽  
pp. 116635 ◽  
Author(s):  
Joan Jiménez-Balado ◽  
Iolanda Riba-Llena ◽  
Jesús Pizarro ◽  
Antoni Palasí ◽  
Anna Penalba ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Kidney Function ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Cerebral Small Vessel Disease and Kidney Function Predict Long-Term Survival in Patients With Acute Stroke

Stroke ◽  
2010 ◽  
Vol 41 (9) ◽  
pp. 1914-1920 ◽  
Author(s):  
Niku K.J. Oksala ◽  
Tapani Salonen ◽  
Timo Strandberg ◽  
Anni Oksala ◽  
Tarja Pohjasvaara ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Kidney Function ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Term Survival ◽  
Long Term Survival ◽  
Vessel Disease

scholarly journals Kidney Function Is Related to Cerebral Small Vessel Disease

Stroke ◽  
2008 ◽  
Vol 39 (1) ◽  
pp. 55-61 ◽  
Author(s):  
M. Arfan Ikram ◽  
Meike W. Vernooij ◽  
Albert Hofman ◽  
Wiro J. Niessen ◽  
Aad van der Lugt ◽  
...  
Keyword(s):  
Kidney Function ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease

2018 ◽  
Vol 20 (9) ◽  
pp. 1260-1265 ◽  
Author(s):  
Aleksandra M. Pavlovic ◽  
Tatjana Pekmezovic ◽  
Jasna Zidverc Trajkovic ◽  
Gordana Tomic ◽  
Edita Cvitan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Brain Lesions ◽  
Small Vessel ◽  
Hypertensive Patients ◽  
Vessel Disease ◽  
Increased Risk

scholarly journals Increased Aortic Pulse Wave Velocity Is Associated With Silent Cerebral Small-Vessel Disease in Hypertensive Patients

Hypertension ◽  
2008 ◽  
Vol 52 (6) ◽  
pp. 1120-1126 ◽  
Author(s):  
Léon H.G. Henskens ◽  
Abraham A. Kroon ◽  
Robert J. van Oostenbrugge ◽  
Ed H.B.M. Gronenschild ◽  
Monique M.J.J. Fuss-Lejeune ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Small Vessel Disease ◽  
Aortic Pulse Wave Velocity ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Hypertensive Patients ◽  
Vessel Disease
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