scholarly journals Cause-Specific Life Expectancies After 35 Years of Age for Human Immunodeficiency Syndrome-Infected and Human Immunodeficiency Syndrome-Negative Individuals Followed Simultaneously in Long-term Cohort Studies, 1984–2008

2013 ◽  
Vol 177 (2) ◽  
pp. 116-125 ◽  
Author(s):  
Nikolas Wada ◽  
Lisa P. Jacobson ◽  
Mardge Cohen ◽  
Audrey French ◽  
John Phair ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Immunodeficiency Syndrome ◽  
Human Immunodeficiency Syndrome

scholarly journals Partial loss of interleukin 2 receptor gamma function in pigs provides mechanistic insights for the study of human immunodeficiency syndrome

Oncotarget ◽  
2016 ◽  
Vol 7 (32) ◽  
pp. 50914-50926 ◽  
Author(s):  
Yun-Jung Choi ◽  
Kiho Lee ◽  
Woo-Jin Park ◽  
Deug-Nam Kwon ◽  
Chankyu Park ◽  
...  
Keyword(s):  
Gamma Function ◽  
Interleukin 2 ◽  
Partial Loss ◽  
Interleukin 2 Receptor ◽  
Immunodeficiency Syndrome ◽  
Human Immunodeficiency Syndrome

scholarly journals S230. LONG-TERM ANTIPSYCHOTIC MEDICATION IN SCHIZOPHRENIA: BENEFITS, RISKS AND FOLLOW-UP: DATA FROM FINNISH COHORT STUDIES AND SYSTEMATIC REVIEW

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S415-S416
Author(s):  
Matti Isohanni ◽  
Jouko Miettunen ◽  
Erika Jääskeläinen ◽  
Jani Moilanen ◽  
Anja Hulkko ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Antipsychotic Medication

B cell acute lymphocytic leukemia in adults. Clinical, morphologic, and immunologic findings.

1986 ◽  
Vol 4 (5) ◽  
pp. 737-743 ◽  
Author(s):  
P S Gill ◽  
P R Meyer ◽  
Z Pavlova ◽  
A M Levine
Keyword(s):  
B Cell ◽  
Acute Lymphocytic Leukemia ◽  
Disease Free Survival ◽  
Lymphocytic Leukemia ◽  
Cell Phenotype ◽  
History Of ◽  
Acquired Immunodeficiency ◽  
Immunologic Marker ◽  
Immunodeficiency Syndrome

Acute lymphocytic leukemia (ALL) is a heterogeneous group of disorders, clinically, immunologically, and pathologically. ALL of a B cell phenotype (B-ALL) is the least common. We have studied ten adult patients with B-ALL, none of whom had a tumor mass. The median age was 56 years (range, 30 to 90). A history of an altered immune state was noted in four cases: a distant history of Hashimoto's thyroiditis in one, pregnancy in one, and acquired immunodeficiency syndrome in two. Two patients presented with CNS involvement, and in two additional patients CNS leukemia developed during the course of disease. By the French-American-British (FAB) classification system, L3 leukemic morphology was present in nine, whereas L2 was present in one. Circulating leukemic blasts varied from less than 500/dL to greater than 15,000/dL. Eight patients were thrombocytopenic, and eight were anemic at presentation. Immunologic marker studies on leukemic blasts revealed monoclonal kappa light chain marking in nine and monoclonal lambda in one. Following chemotherapy, complete remission was achieved in three patients, two of whom experienced relapse within 9 months. The median survival for the group was 3 months, and only one patient experienced long-term, disease-free survival. We conclude that B-ALL in the adult presents with the classic L3 morphologic picture in the majority and is associated with extremely short survival.

scholarly journals A human immunodeficiency syndrome caused by mutations in CARMIL2

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
T. Schober ◽  
T. Magg ◽  
M. Laschinger ◽  
M. Rohlfs ◽  
N. D. Linhares ◽  
...  
Keyword(s):  
Immunodeficiency Syndrome ◽  
Human Immunodeficiency Syndrome

What conclusions should we draw from the data?

1995 ◽  
Vol 84 (02) ◽  
pp. 95-101 ◽  
Author(s):  
Andrew Vickers
Keyword(s):  
Cohort Studies ◽  
External Validity ◽  
Large Scale ◽  
Critical Appraisal ◽  
Internal Validity ◽  
Research Process ◽  
Clinical Value ◽  
Blind Trials

AbstractCritical appraisal of a scientific trial involves deciding on its internal validity— whether the hypothesis has been correctly accepted or rejected—and its external validity—the extent to which the trial's findings can be generalized. Discourse on homoeopathic research has focused on the former at the expense of the latter and an analysis of homoeopathic research demonstrates that it has low external validity. One solution would be to split the research process in two. Large scale, triple-blind trials could be used to determine the extent to which the action of homoeopathy may be explained by placebo. Importantly, no assessment of external validity would be made. Audit and cohort studies could then be used to examine questions usually associated with external validity, such as the conditions most suitable for treatment and the long-term clinical value of homoeopathy.

Can population cohort studies assess the long-term impact of anesthesia in children?

2018 ◽  
Vol 28 (10) ◽  
pp. 930-931 ◽  
Author(s):  
Susanna Ritchie-McLean ◽  
Sally Wilmshurst
Keyword(s):  
Cohort Studies ◽  
Population Cohort ◽  
Long Term Impact
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