scholarly journals Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones

2009 ◽  
Vol 169 (11) ◽  
pp. 1319-1326 ◽  
Author(s):  
M. S. Kramer ◽  
J. Lydon ◽  
L. Seguin ◽  
L. Goulet ◽  
S. R. Kahn ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Preterm Birth ◽  
Stress Hormones ◽  
Spontaneous Preterm Birth

scholarly journals IL-37 Exerts Anti-Inflammatory Effects in Fetal Membranes of Spontaneous Preterm Birth via the NF-κB and IL-6/STAT3 Signaling Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Lulu Wang ◽  
Zheng Liu ◽  
Dongni Huang ◽  
Yuxin Ran ◽  
Hanwen Zhang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Signaling Pathway ◽  
Biological Effects ◽  
Clinical Samples ◽  
Fetal Membranes ◽  
Spontaneous Preterm Birth ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Anti Inflammatory

Spontaneous preterm birth (sPTB), defined as delivery before 37 weeks of gestation, is thought to be a multifactorial syndrome. However, the inflammatory imbalance at the maternal-fetal interface promotes excessive secretion of inflammatory factors and induces apoptosis and degradation of the extracellular matrix (ECM), which can subsequently lead to preterm birth. As an anti-inflammatory molecule in the IL-1 family, interleukin-37 (IL-37) mainly plays an inhibiting role in a variety of inflammatory diseases. However, as a typical inflammatory disease, no previous studies have been carried out to explore the role of IL-37 in sPTB. In this study, a series of molecular biological experiments were performed in clinical samples and human amniotic epithelial cell line (Wistar Institute Susan Hayflick (WISH)) to investigate the deficiency role of IL-37 and the potential mechanism. Firstly, the results indicated that the expression of IL-37 in human peripheral plasma and fetal membranes was significantly decreased in the sPTB group. Afterward, it is proved that IL-37 could significantly suppress the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in WISH cells. Simultaneously, once silence IL-37, LPS-induced apoptosis and activity of matrix metalloproteinases (MMPs) 2 and 9 were significantly increased. In addition, the western blot data showed that IL-37 performed its biological effects by inhibiting the NF-κB and IL-6/STAT3 pathway. In conclusion, our results suggest that IL-37 limits excessive inflammation and subsequently inhibits ECM remodeling and apoptosis through the NF-κB and IL-6/STAT3 signaling pathway in the fetal membranes.

Role of progestogens in women at risk for spontaneous preterm birth: the final word?

The Lancet ◽  
2021 ◽  
Vol 397 (10280) ◽  
pp. 1158-1159
Author(s):  
Sherrine A Ibrahim ◽  
David M Haas
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Spontaneous Preterm Birth ◽  
Final Word

scholarly journals Mediterranean-Style Diet and Birth Outcomes in an Urban, Multiethnic, and Low-Income US Population

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1188
Author(s):  
Dong Keun Rhee ◽  
Yuelong Ji ◽  
Xiumei Hong ◽  
Colleen Pearson ◽  
Xiaobin Wang ◽  
...  
Keyword(s):  
African American ◽  
Birth Weight ◽  
Preterm Birth ◽  
African American Women ◽  
Birth Outcomes ◽  
Low Income ◽  
Spontaneous Preterm Birth ◽  
Hispanic White ◽  
Pregnancy And Birth

Findings on the role of Mediterranean-style diet (MSD) on duration of pregnancy and birth weight have been inconsistent and based largely on Non-Hispanic white populations, making it unclear as to whether they could extend to African Americans who are at a higher risk of unfavorable birth outcomes. Our study addresses this gap using a large urban, multiethnic, predominantly low-income cohort of mother-infant dyads from Boston, MA, USA. Dietary information was obtained via food frequency questionnaires; health information including birth outcomes were extracted from medical records. A Mediterranean-style diet score (MSDS) was formulated based on intake history, and linear and log-binomial regressions were performed to assess its association with birth outcomes. After adjustment, the lowest MSDS quintile from the overall sample was found to be associated with an increased relative risk (RR) of overall preterm birth (RR 1.18; 95% CI: 1.06–1.31), spontaneous preterm birth (1.28; 1.11–1.49), late preterm birth (1.21; 1.05–1.39), and low birth weight (1.11; 1.01–1.22), compared to the highest quintile. The findings were similar for the African American sample. Our study adds to the current understanding of the diet’s influence on birth outcomes by demonstrating that adherence to MSD may improve birth outcomes for African American women.

scholarly journals A possible role of aryl hydrocarbon receptor in spontaneous preterm birth

2015 ◽  
Vol 84 (5) ◽  
pp. 494-497 ◽  
Author(s):  
Yan Li ◽  
Kai Wang ◽  
Qing-Yun Zou ◽  
Chi Zhou ◽  
Ronald R. Magness ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Aryl Hydrocarbon Receptor ◽  
Spontaneous Preterm Birth ◽  
Aryl Hydrocarbon

scholarly journals Mid-gestation serum lipidomic profile associations with spontaneous preterm birth are influenced by body mass index

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0239115
Author(s):  
Kamil Borkowski ◽  
John W. Newman ◽  
Nima Aghaeepour ◽  
Jonathan A. Mayo ◽  
Ivana Blazenović ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Body Mass ◽  
Elevated Serum ◽  
Normal Weight ◽  
Estrogen Metabolism ◽  
Obese Women ◽  
Epoxyeicosatrienoic Acid ◽  
Spontaneous Preterm Birth ◽  
Unsaturated Triglycerides

Spontaneous preterm birth (sPTB) is a major cause of infant morbidity and mortality. While metabolic changes leading to preterm birth are unknown, several factors including dyslipidemia and inflammation have been implicated and paradoxically both low (<18.5 kg/m2) and high (>30 kg/m2) body mass indices (BMIs) are risk factors for this condition. The objective of the study was to identify BMI-associated metabolic perturbations and potential mid-gestation serum biomarkers of preterm birth in a cohort of underweight, normal weight and obese women experiencing either sPTB or full-term deliveries (n = 102; n = 17/group). For this purpose, we combined untargeted metabolomics and lipidomics with targeted metabolic profiling of major regulators of inflammation and metabolism, including oxylipins, endocannabinoids, bile acids and ceramides. Women who were obese and had sPTB showed elevated oxidative stress and dyslipidemia characterized by elevated serum free fatty acids. Women who were underweight-associated sPTB also showed evidence of dyslipidemia characterized by elevated phospholipids, unsaturated triglycerides, sphingomyelins, cholesteryl esters and long-chain acylcarnitines. In normal weight women experiencing sPTB, the relative abundance of 14(15)-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acids to other regioisomers were altered at mid-pregnancy. This phenomenon is not yet associated with any biological process, but may be linked to estrogen metabolism. These changes were differentially modulated across BMI groups. In conclusion, using metabolomics we observed distinct BMI-dependent metabolic manifestations among women who had sPTB. These observations suggest the potential to predict sPTB mid-gestation using a new set of metabolomic markers and BMI stratification. This study opens the door to further investigate the role of cytochrome P450/epoxide hydrolase metabolism in sPTB.

Role of periodontitis in systemic health: spontaneous preterm birth

1998 ◽  
Vol 62 (10) ◽  
pp. 852-858 ◽  
Author(s):  
S Offenbacher ◽  
JD Beck ◽  
S Lieff ◽  
G Slade
Keyword(s):  
Preterm Birth ◽  
Spontaneous Preterm Birth ◽  
Systemic Health
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