scholarly journals Vitamin D supplementation has minor effects on parathyroid hormone and bone turnover markers in vitamin D–deficient bedridden older patients

2007 ◽  
Vol 37 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Mikko Björkman ◽  
Antti Sorva ◽  
Juha Risteli ◽  
Reijo Tilvis
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Older Patients ◽  
Vitamin D Supplementation ◽  
Turnover Markers

scholarly journals Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study

2008 ◽  
Vol 100 (1) ◽  
pp. 197-207 ◽  
Author(s):  
Rikke Andersen ◽  
Christian Mølgaard ◽  
Lene T. Skovgaard ◽  
Christine Brot ◽  
Kevin D. Cashman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Vitamin D Supplementation ◽  
Whole Body ◽  
Pakistani Origin ◽  
Pakistani Immigrants ◽  
Turnover Markers ◽  
Double Blinded

Severe vitamin D deficiency is common among Muslim immigrants. The dose necessary to correct the deficiency and its consequence for bone health are not known for immigrants. The aim was to assess the effect of relatively low dosages of supplemental vitamin D on vitamin D and bone status in Pakistani immigrants. This 1-year-long randomised double-blinded placebo-controlled intervention with vitamin D3 (10 and 20 μg/d) included girls (10·1–14·7 years), women (18·1–52·7 years) and men (17·9–63·5 years) of Pakistani origin living in Denmark. The main endpoints were serum 25-hydroxyvitamin D (S-25OHD), parathyroid hormone, bone turnover markers and bone mass. The study showed that supplementation with 10 and 20 μg vitamin D3 per d increased S-25OHD concentrations similarly in vitamin D-deficient Pakistani women (4-fold), and that 10 μg increased S-25OHD concentrations 2-fold and 20 μg 3-fold in Pakistani men. S-25OHD concentrations increased at 6 months and were stable thereafter. Baseline S-25OHD concentrations tended to be lower in girls and women than in men; females achieved about 46 nmol/l and men 55 nmol/l after supplementation. Serum intact parathyroid hormone concentrations decreased at 6 months, but there was no significant effect of the intervention on bone turnover markers and dual-energy X-ray absorptiometry measurements of the whole body and lumbar spine.

scholarly journals Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency

Bone ◽  
2019 ◽  
Vol 124 ◽  
pp. 7-13 ◽  
Author(s):  
Rolf Jorde ◽  
Astrid Kamilla Stunes ◽  
Julia Kubiak ◽  
Ragnar Joakimsen ◽  
Guri Grimnes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
Bone Turnover Markers ◽  
Vitamin D Supplementation ◽  
Related Substances ◽  
Turnover Markers

scholarly journals Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial

Nutrients ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 432 ◽  
Author(s):  
Verena Schwetz ◽  
Christian Trummer ◽  
Marlene Pandis ◽  
Martin Grübler ◽  
Nicolas Verheyen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Randomized Controlled ◽  
Turnover Markers

scholarly journals The Effects of Season-Long Vitamin D Supplementation on Collegiate Swimmers and Divers

2013 ◽  
Vol 23 (5) ◽  
pp. 431-440 ◽  
Author(s):  
Regina M. Lewis ◽  
Maja Redzic ◽  
D. Travis Thomas
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Bone Turnover ◽  
Inflammatory Cytokines ◽  
Bone Turnover Markers ◽  
Female Athletes ◽  
Vitamin D Supplementation ◽  
Mineral Density ◽  
Turnover Markers ◽  
Total Body

The purpose of this 6-month randomized, placebo-controlled trial was to determine the effect of season-long (September–March) vitamin D supplementation on changes in vitamin D status, which is measured as 25(OH) D, body composition, inflammation, and frequency of illness and injury. Forty-five male and female athletes were randomized to 4,000 IU vitamin D (n = 23) or placebo (n = 22). Bone turnover markers (NTx and BSAP), 25(OH)D, and inflammatory cytokines (TNF-alpha, IL-6, and IL1-β) were measured at baseline, midpoint, and endpoint. Body composition was assessed by DXA and injury and illness data were collected. All athletes had sufficient 25(OH)D (> 32 ng/ml) at baseline (mean: 57 ng/ml). At midpoint and endpoint, 13% and 16% of the total sample had 25(OH)D < 32 ng/ml, respectively. 25(OH)D was not positively correlated with bone mineral density (BMD) in the total body, proximal dual femur, or lumbar spine. In men, total body (p = .04) and trunk (p = .04) mineral-free lean mass (MFL) were positively correlated with 25(OH)D. In women, right femoral neck BMD (p = .02) was positively correlated with 25(OH)D. 25(OH)D did not correlate with changes in bone turnover markers or inflammatory cytokines. Illness (n = 1) and injury (n = 13) were not related to 25(OH)D; however, 77% of injuries coincided with decreases in 25(OH)D. Our data suggests that 4,000 IU vitamin D supplementation is an inexpensive intervention that effectively increased 25(OH)D, which was positively correlated to bone measures in the proximal dual femur and MFL. Future studies with larger sample sizes and improved supplement compliance are needed to expand our understanding of the effects of vitamin D supplementation in athletes.

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