scholarly journals Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial

2007 ◽  
Vol 37 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Tracey Tsang ◽  
Rhonda Orr ◽  
Paul Lam ◽  
Elizabeth Comino ◽  
Maria Fiatarone Singh
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Insulin Sensitivity ◽  
Glucose Homeostasis ◽  
Tai Chi ◽  
Controlled Trial ◽  
Double Blind

scholarly journals Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Rosiglitazone

PPAR Research ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ying-Chuen Lai ◽  
Hung-Yuan Li ◽  
Ta-Jen Wu ◽  
Chi-Yuan Jeng ◽  
Lee-Ming Chuang
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Total Cholesterol ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Model Assessment ◽  
Double Blind ◽  
Acid Labile Subunit ◽  
Acid Labile

Silencing of acid-labile subunit (ALS) improved glucose metabolism in animal models. The aim of this study is to evaluate the effects of rosiglitazone (RSG) on ALS levels in individuals with type 2 diabetes. A randomized, double-blind, placebo-controlled trial was conducted. Subjects with type 2 diabetes mellitus were randomly distributed to an RSG-treated(n=30)or a placebo(n=31)group. Patients were evaluated prior to treatment at baseline and at 12 and 24 weeks after treatment. At baseline, ALS levels were negatively associated with low-density lipoprotein cholesterol (LDLc) levels and homeostatic model assessment version 2 insulin sensitivity (HOMA2-%S). Over 24 weeks, there was a significantly greater reduction in ALS levels in the nonobese RSG-treated individuals than placebo-treated group. The effect of RSG on ALS was not significant in obese individuals. Fasting plasma glucose and hemoglobin A1c were reduced, but total cholesterol and LDLc were increased, in patients on RSG. Change in ALS levels predicted changes in total cholesterol and HOMA2-%S over time. This study suggested a BMI-dependent effect of RSG treatment on ALS levels. Reduction of ALS by RSG increases the risk of atherosclerosis in individuals with type 2 diabetes.

scholarly journals The Effects of Tai Chi on Peripheral Somatosensation, Balance, and Fitness in Hispanic Older Adults with Type 2 Diabetes: A Pilot and Feasibility Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Elisabeth I. Cavegn ◽  
Jody L. Riskowski
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Plantar Pressure ◽  
Tai Chi ◽  
Controlled Trial ◽  
Neuromuscular Control ◽  
Convenience Sample ◽  
Study Results ◽  
Ankle Proprioception

Peripheral neuropathy and loss of somatosensation in older adults with type 2 diabetes can increase risk of falls and disability. In nondiabetic older adult population Tai Chi has been shown to enhance balance and fitness through improvements in somatosensation and neuromuscular control, and it is unclear if Tai Chi would elicit similar benefits in older adults with diabetes. Therefore, the purpose of this study was to investigate the effects of an 8-week, three-hour-per-week Tai Chi intervention on peripheral somatosensation in older adults with type 2 diabetes. Participants were eight Hispanic older adults with type 2 diabetes who participated in the Tai Chi intervention and a convenience sample of Hispanic older adults as a referent group. Baseline and postintervention assessments included ankle proprioception, foot tactile sense, plantar pressure distribution, balance, and fitness. After intervention, older adults with type 2 diabetes showed significant improvements in ankle proprioception and fitness and decreased plantar pressure in the forefoot, with no statistical effect noted in balance or tactile sensation. Study results suggest that Tai Chi may be beneficial for older adults with diabetes as it improves ankle proprioception; however, study findings need to be confirmed in a larger sample size randomized controlled trial.

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