Incentivizing New Veterinary Pharmaceutical Products to Combat Antibiotic Resistance

2019 ◽  
Vol 42 (4) ◽  
pp. 653-673 ◽  
Author(s):  
Stacy Sneeringer ◽  
Matt Clancy
Keyword(s):  
Antibiotic Resistance ◽  
Pharmaceutical Products ◽  
Veterinary Pharmaceutical

Human exposures to veterinary pharmaceutical products reported to Australia’s largest poison information centre

2019 ◽  
Vol 57 (10) ◽  
pp. 855-866 ◽  
Author(s):  
Claire E. Wylie ◽  
Rose Cairns ◽  
Jared A. Brown ◽  
Nicholas A. Buckley
Keyword(s):  
Pharmaceutical Products ◽  
Information Centre ◽  
Veterinary Pharmaceutical

scholarly journals Issues Related to the Use of Canines in Toxicologic Pathology—Issues With Pharmacokinetics and Metabolism

2003 ◽  
Vol 31 (1_suppl) ◽  
pp. 17-24 ◽  
Author(s):  
Jay Tibbitts
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Protein Binding ◽  
Species Differences ◽  
Drug Disposition ◽  
Pharmaceutical Products ◽  
Dose Selection ◽  
Gastrointestinal Physiology ◽  
Veterinary Pharmaceutical

The dog is a commonly used animal model by virtue of its size, well-characterized physiology, and ease of handling. For these reasons and others, dogs are also useful in pharmacokinetic and metabolism studies during the development of both human and veterinary pharmaceutical products. In comparison with humans, or with other animals, dogs have some unique physiologic attributes that can affect the disposition of drugs. Species differences in gastrointestinal physiology, metabolism, renal function, and protein binding can affect the correlation of the pharmacokinetics and toxicology of dogs with those of other species. With the use of relevant examples, this article will provide an introduction to characteristics of dog physiology and their impact on pharmacokinetics, metabolism, drug disposition, toxicity, and dose selection.

scholarly journals Cross-Contamination of Enrofloxacin in Veterinary Medicinal and Nutritional Products in Korea

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 128
Author(s):  
JeongWoo Kang ◽  
Md. Akil Hossain ◽  
Hae-chul Park ◽  
Ok me Jeong ◽  
Sung-won Park ◽  
...  
Keyword(s):  
Pharmaceutical Products ◽  
Poultry Meat ◽  
Inappropriate Drug ◽  
Human Consumption ◽  
Poultry Production ◽  
Veterinary Pharmaceutical ◽  
Liquid Chromatography Tandem Mass ◽  
Drug Manufacturing ◽  
Drug Contamination ◽  
Meat And Eggs

Poultry meat and eggs are vital sources of protein for human consumption worldwide. The use of several nutritional and medicinal products, including antibiotics, is crucial for efficient and safe poultry production. Accumulation of drug residues in meat and eggs from inappropriate drug use is a major concern to public health. Recently, enrofloxacin was detected (2.4–3.8 ppb) in edible eggs produced in Jeju Island, Korea. Although the farm from which the enrofloxacin-contaminated eggs were collected did not use enrofloxacin-containing products, they reported extensive use of a nutritional product (NPJ). Accordingly, in this study, we investigated whether enrofloxacin contamination had occurred accidentally in various widely used veterinary pharmaceutical products. Enrofloxacin content (4.57–179.08 ppm) in different lots of the NPJ was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Furthermore, 76 veterinary pharmaceutical products that are widely used in poultry farms in Korea and claim to not contain enrofloxacin were collected and analyzed by LC-MS/MS. Among them, a florfenicol product and a sulfatrimethoprime product were found to contain 3.00 and 0.57 ppm enrofloxacin, respectively. These results suggest that appropriate manufacturing standards are not being followed and that strict monitoring of drug manufacturing is necessary in Korea to avoid drug contamination.

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