scholarly journals Perspective: Advancing Understanding of Population Nutrient–Health Relations via Metabolomics and Precision Phenotypes

2019 ◽  
Vol 10 (6) ◽  
pp. 944-952 ◽  
Author(s):  
Stephanie Andraos ◽  
Melissa Wake ◽  
Richard Saffery ◽  
David Burgner ◽  
Martin Kussmann ◽  
...  

ABSTRACT Diet and lifestyle are vital to population health, but their true contribution is difficult to quantify using traditional methods. Nutrient–health relations are typically based on epidemiological associations that are assessed at the population level, traditionally using self-reported dietary and lifestyle data. Unfortunately, such measures are inherently inaccurate. New technologies such as metabolomics can measure nutritional and micronutrient profiles in body fluids, providing objective evaluation of nutritional status. A critical step toward accurate health prediction models would be the building of integrated repositories of nutritional measures combining subjective methods of reporting with objective metabolomics profiles and precise phenotypic data. Here we outline a roadmap to achieve this goal and discuss both the advantages and risks of this approach. We also highlight the uncertain associations between the complexity of high-dimensional data generated in ‘omics research (along with the public confusion this may engender) and the rapid adoption of ‘omics approaches by nutrition and health companies to develop nutritional products and services.

2018 ◽  
pp. 255-262
Author(s):  
Brent A Barrett ◽  
Marty J Faville ◽  
Kioumars Ghamkhar ◽  
Marcelo J Carena

The rate of genetic gain represented in the Forage Value Index of perennial ryegrass (Lolium perenne) is a major factor underpinning sustained profitability in pastoral farming. Effective new technologies for trait data acquisition and parent plant selection are used in many animal and crop improvement programmes to lift the rate of gain, but have yet to be developed and integrated in forage breeding. For forage improvement, hypotheses tested were: a) genomic selection (GS) offers a viable breeding strategy, and b) key enabling technologies for non-destructive, high-throughput phenotyping (HTP) in the field will improve trait data acquisition. To evaluate GS, extensive molecular marker and phenotypic datasets in structured populations of perennial ryegrass were developed. Phenotypic data for seasonal dry matter yield (DMY), the core trait in the Dairy NZ Forage Value Index, were obtained replicated field trials. Data on heading date (HD) as a useful trait to assess the efficacy of GS for simply inherited traits, were also collected. Genomic prediction models were developed for seasonal DMY and HD. Application of GS for HD was effective in selecting for both early and late heading, with movement of up to 7 days in a single generation of selection. The HTP research used iterative development of computational methods supporting a repeatable, non-invasive means of accurately and rapidly measuring DMY of perennial ryegrass in single row plots. These findings demonstrate effective genetic prediction and phenotyping approaches which may enable breeders to lift the rate of genetic gain in perennial ryegrass.


2018 ◽  
Vol 7 (1) ◽  
pp. 157-164
Author(s):  
Rubiane Inara Wagner ◽  
Patrícia Molz ◽  
Camila Schreiner Pereira

O objetivo deste estudo foi comparar a frequência do consumo de alimentos processados e ultraprocessados e verificar a associação entre estado nutricional por adolescentes do ensino público e privado do município de Arroio do Tigre, RS. Trata-se de um estudo transversal realizado com adolescentes, com idade entre 10 e 15 anos, de uma escola pública e uma privada de Arroio do Tigre, RS. O estado nutricional foi avaliado pelo índice de massa corporal. Aplicou-se um questionário de frequência alimentar contendo alimentos processados e ultraprocessados. A amostra foi composta por 64 adolescentes com idade média de 12,03±1,15 anos, sendo 53,1% da escola pública. A maioria dos adolescentes encontravam-se eutróficos (p=0,343), e quando comparado com o consumo de alimentos processados e ultraprocessados, a maioria dos escolares eutróficos relataram maior frequência no consumo de balas e chicletes (50,0%) e barra de cereais (51,0%), de 1 a 3 vezes por semana (p=0,004; p=0,029, respectivamente). Houve também uma maior frequência de consumo de alimentos processados e ultraprocessados como pizza (73,5%; p0,001), refrigerante (58,8%; p=0,036) e biscoito recheado (58,8%; p=0,008) entre 1 a 3 vezes por semana na escola pública em comparação a escola privada. O consumo de suco de pacote (p=0,013) foi relatado não ser consumido pela maioria dos alunos da escola particular em comparação a escola pública. Os dados encontrados evidenciam um consumo expressivo de alimentos processados e ultraprocessados pelos adolescentes de ambas as escolas, destacando alimentos com alto teor de açúcar e sódio.Palavras-chave: Hábitos alimentares. Adolescentes. Alimentos industrializados. ABSTRACT: The objective of this study was to compare the frequency of consumption of processed and ultraprocessed foods and to verify the association between nutritional status by adolescents from public and private schools in the municipality of Arroio do Tigre, RS. This was a cross-sectional study conducted with adolescents, aged 10 to 15 years, from a public school and a private school in Arroio do Tigre, RS. Nutritional status was assessed by body mass index. A food frequency questionnaire containing processed and ultraprocessed foods was applied. The sample consisted of 64 adolescents with a mean age of 12.03±1.15 years, 53.1% of the public school. Most of the adolescents were eutrophic (p=0.343), and when compared to the consumption of processed and ultraprocessed foods, most eutrophic schoolchildren reported a higher frequency of bullets and chewing gum (50.0%) and cereal bars (51.0%), 1 to 3 times per week (p=0.004, p=0.029, respectively). There was also a higher frequency of consumption of processed and ultraprocessed foods such as pizza (73.5%, p0.001), refrigerant (58.8%, p=0.036) and stuffed biscuit (58.8%, p=0.008) between 1 to 3 times a week in public school compared to private school. Consumption of packet juice (p=0.013) was reported not to be consumed by the majority of private school students compared to public school. Conclusion: The data found evidenced an expressive consumption of processed and ultraprocessed foods by the adolescents of both schools, highlighting foods with high sugar and sodium content.Keywords: Food Habits. Adolescents. Industrialized Foods.


2012 ◽  
Vol 153 (26) ◽  
pp. 1023-1030 ◽  
Author(s):  
Éva Martos ◽  
Viktória Anna Kovács ◽  
Márta Bakacs ◽  
Csilla Kaposvári ◽  
Andrea Lugasi

Obesity is a leading public health problem, but representative data on measured prevalence among Hungarian adults has been missing since the late eighties. Aim and method: Joining in European Health Interview Survey the aim of the OTAP2009 study was to provide data representative by age and gender on the prevalence of obesity and abdominal obesity among Hungarian adults based on their measured anthropometric data. Results: Participation rate was 35% (n = 1165). Data shows that nearly two-thirds of adults are overweight or obese. 26.2% of men and 30.4% of women are obese. Prevalence of morbid obesity is 3.1% and 2.6% in men and women, respectively. Abdominal obesity is more prevalent among women than men (51.0% vs. 33.2%), and rate is increasing parallel with age in both gender. In elderly, 55% of men and almost 80% of women are abdominally obese. Conclusions: Besides interventions of population level for tackling obesity, individual preventive measures are indispensable. Orv. Hetil., 2012, 153, 1023–1030.


Author(s):  
Michael Szollosy

This chapter introduces the “Perspectives” section of the Handbook of Living Machines offering an overview of the different contributions gathered here that consider how biomimetic and biohybrid systems will transform our personal lives and social organizations, and how we might respond to the challenges that these transformations will inevitably pose to our ‘posthuman’ worlds. The authors in this section see it as essential that those who aspire to create living machines engage with the public to confront misconceptions, deep anxieties, and unrealistic aspirations that presently dominate the cultural imagination, and to include potential users in questions of design and utility as new technologies are being developed. Human augmentation and enhancement are other important themes addressed, raising important questions about what it means fundamentally to be ‘human’. These questions and challenges are addressed through the lens of the social and personal impacts of new technologies on human selves, the public imagination, ethics, and human relationships.


Buildings ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 95
Author(s):  
Ghazal Makvandia ◽  
Md. Safiuddin

Efforts have been put in place to minimize the effects of construction activities and occupancy, but the problem of greenhouse gas (GHG) emissions continues to have detrimental effects on the environment. As an effort to reduce GHG emissions, particularly carbon emissions, countable commercial, industrial, institutional, and residential net-zero energy (NZE) buildings were built around the globe during the past few years, and they are still operating. But there exist many challenges and barriers for the construction of NZE buildings. This study identifies the obstacles to developing NZE buildings, with a focus on single-family homes, in the Greater Toronto Area (GTA). The study sought to identify the technical, organizational, and social challenges of constructing NZE buildings, realize the importance of the public awareness in making NZE homes, and provide recommendations on how to raise public knowledge. A qualitative approach was employed to collect the primary data through survey and interviews. The secondary data obtained from the literature review were also used to realize the benefits, challenges, and current situation of NZE buildings. Research results indicate that the construction of NZE buildings is faced with a myriad of challenges, including technical issues, the lack of governmental and institutional supports, and the lack of standardized measures. The public awareness of NZE homes has been found to be very low, thus limiting the uptake and adoption of the new technologies used in this type of homes. The present study also recommends that the government and the academic institutions should strive to support the NZE building technology through curriculum changes, technological uptake, and financial incentives to buyers and developers. The implementation of these recommendations may enhance the success and popularity of NZE homes in the GTA.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mohamed Z. Elbashir ◽  
Steve G. Sutton ◽  
Vicky Arnold ◽  
Philip A. Collier

Purpose Recent research and policy reports indicate public sector organizations struggle to leverage information technology-based performance measurement systems and fail to effectively evaluate performance beyond financial metrics. This study aims to focus on organizational factors that influence the assimilation of business intelligence (BI) systems into integrated management control systems and the corollary impact on improving business process performance within public sector organizations. Design/methodology/approach The complete Australian client list was acquired from a leading BI vendor; and the authors surveyed all public sector organizations, receiving 226 individual responses representing 160 public sector organizations in Australia. Using latent construct measurement, structural equation modeling (SEM)-partial least squares is used to test the theoretical model. Findings When top management promotes knowledge creation among the organization’s operational level employees and support their activities with strong BI infrastructure, the same knowledge and infrastructure capabilities that are critical to assimilation in private sector hold in the public sector. However, public sector organizations generally have difficulty retaining staff with expertise in new technologies and attracting new innovative staff that can leverage smart systems to effect major change in performance measurement. When top management effectively manages knowledge importation from external entities to counteract deficiencies, public sector organizations effectively assimilate BI knowledge into performance measurement yielding strong process performance. Research limitations/implications When top management promotes knowledge creation among the organization’s operational level employees and support their activities with strong BI infrastructure, the same knowledge and infrastructure capabilities critical to assimilation in the private sector hold in the public sector. However, public sector organizations generally have difficulty retaining staff with expertise in new technologies and attracting new innovative staff that can leverage smart systems to effect major change in performance measurement. The research extends the theory behind organizational absorptive capacity by highlighting how knowledge importation can be used as an external source facilitating internal knowledge creation. This collaborative knowledge creation leads to affective assimilation of BI technologies and associated performance gains. Practical implications The results provide guidance to public sector organizations that struggle to measure and validate service outcomes under New Public Management regulations and mandates. Originality/value The results reveal that consistent with the philosophies behind New Public Management strategies, private sector measures for increasing organizational absorptive capacity can be applied in the public sector. However, knowledge importation appears to be a major catalyst in the public sector where the resources to retain skilled professionals with an ability to leverage contemporary technologies into service performance are often very limited. Top management team knowledge and skills are critical to effectively leveraging these internal and external knowledge creation mechanisms.


Author(s):  
S. Rochford ◽  
P. Dodd ◽  
C. Austin

Abstract This article provides an overview of the public health approach to suicide in Ireland. The authors provide detail on the current suicide prevention strategy in Ireland, Connecting for Life, which is a whole-of-government, systemic, multicomponent national strategy. As the strategy enters its final extended phase of implementation over the period 2020–2024, the public health elements of Connecting for Life are presented, including the population level and more targeted approaches. The findings of an interim review of the strategy are discussed, in addition to the local and national implementation structures which are in place to assist implementation and monitoring of the strategy.


2021 ◽  
Author(s):  
Zhuo Zhao ◽  
Rui Li ◽  
Yangmyung Ma ◽  
Iman Islam ◽  
Abdul M. Azam Rajper ◽  
...  

UNSTRUCTURED During COVID-19, the clinical and healthcare demands have been on the rapid rise. Major challenges to addressing the pandemic include a lack of testing kits and shortages of ventilators to treat severe cases of COVID-19, insufficient accessibility to personal protective equipment for both hospitals and the public. New technologies have been developed by scientists, researchers, and companies in response to these demands. In this paper, 90 news articles and scientific reports on COVID-19-related innovations during 2020-2021 were screened and shortlisted to form a pool of candidates yielding a total of 20 publications for review which were then categorized into three sections: personal protective equipment, testing methods, and medical treatments. Each study was analyzed for its engineering characteristics and potential social impact on the COVID-19 pandemic. Finally, the guidelines for future disease prevention, diagnosis and treatment were summarized and discussed.


2021 ◽  
pp. 251484862110614
Author(s):  
Holly Jean Buck

Can fossil-based fuels become carbon neutral or carbon negative? The oil and gas industry is facing pressure to decarbonize, and new technologies are allowing companies and experts to imagine lower-carbon fossil fuels as part of a circular carbon economy. This paper draws on interviews with experts, ethnographic observations at carbontech and carbon management events, and interviews with members of the public along a suggested CO2 pipeline route from Iowa to Texas, to explore: What is driving the sociotechnical imaginary of circular fossil carbon among experts, and what are its prospects? How do people living in the landscapes that are expected to provide carbon utilization and removal services understand their desirability and workability? First, the paper examines a contradiction in views of carbon professionals: while experts understand the scale of infrastructure, energy, and capital required to build a circular carbon economy, they face constraints in advocating for policies commensurate with this scale, though they have developed strategies for managing this disconnect. Second, the paper describes views from the land in the central US, surfacing questions about the sustainability of new technologies, the prospect of carbon dioxide pipelines, and the way circular carbon industries could intersect trends of decline in small rural towns. Experts often fail to consider local priorities and expertise, and people in working landscapes may not see the priorities and plans of experts, constituting a “double unseeing.” Robust energy democracy involves not just resistance to dominant imaginaries of circular carbon, but articulation of alternatives. New forms of expert and community collaboration will be key to transcending this double unseeing and furthering energy democracy.


Sign in / Sign up

Export Citation Format

Share Document