scholarly journals Molecular signal integration. Interplay between serine, threonine, and tyrosine phosphorylation.

1992 ◽  
Vol 3 (6) ◽  
pp. 583-592 ◽  
Author(s):  
J Posada ◽  
J A Cooper
Keyword(s):  
Tyrosine Phosphorylation ◽  
Signal Integration ◽  
Molecular Signal

scholarly journals A Molecular Signal Integration Network Underpinning Arabidopsis Seed Germination

2020 ◽  
Vol 30 (19) ◽  
pp. 3703-3712.e4 ◽  
Author(s):  
Hao Xu ◽  
Ourania Lantzouni ◽  
Tonko Bruggink ◽  
Rene Benjamins ◽  
Frank Lanfermeijer ◽  
...  
Keyword(s):  
Seed Germination ◽  
Signal Integration ◽  
Arabidopsis Seed ◽  
Molecular Signal

EGFR induced-tyrosine phosphorylation of ZO-1 may regulate the liver metastasis of colorecial cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A168-A168
Author(s):  
T KAIHARA ◽  
T KUSAKA ◽  
H KAWAMATA ◽  
Y ODA ◽  
J IMURA ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Tyrosine Phosphorylation

Protein-tyrosine Kinase p72 syk Is Activated by Platelet Activating Factor in Platelets

1994 ◽  
Vol 72 (06) ◽  
pp. 937-941 ◽  
Author(s):  
Karim Rezaul ◽  
Shigeru Yanagi ◽  
Kiyonao Sada ◽  
Takanobu Taniguchi ◽  
Hirohei Yamamura
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Phosphorylation ◽  
Protein Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Critical Role ◽  
Platelet Activating Factor ◽  
Kinase Assay ◽  
Potential Candidate ◽  
Protein Tyrosine ◽  
Induced Aggregation

SummaryIt has been demonstrated that activation of platelets by platelet-activating factor (PAF) results in a dramatic increase in tyrosine phosphorylation of several cellular proteins. We report here that p72 syk is a potential candidate for the protein-tyrosine phosphorylation following PAF stimulation in porcine platelets. Immunoprecipitation kinase assay revealed that PAF stimulation resulted in a rapid activation of p72 syk which peaked at 10 s. The level of activation was found to be dose dependent and could be completely inhibited by the PAF receptor antagonist, CV3988. Phosphorylation at the tyrosine residues of p72 syk coincided with activation of yllsyk. Pretreatment of platelets with aspirin and apyrase did not affect PAF induced activation of p72 syk .Furthermore, genistein, a potent protein-tyrosine-kinase inhibitor, diminished PAF-induced p72 syk activation and Ca2+ mobilization as well as platelet aggregation. These results suggest that p72 syk may play a critical role in PAF-induced aggregation, possibly through regulation of Ca2+ mobilization.

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