scholarly journals SignaFish: A Zebrafish-Specific Signaling Pathway Resource

Zebrafish ◽  
2016 ◽  
Vol 13 (6) ◽  
pp. 541-544 ◽  
Author(s):  
Kitti Csályi ◽  
Dávid Fazekas ◽  
Tamás Kadlecsik ◽  
Dénes Türei ◽  
Leila Gul ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Specific Signaling Pathway

scholarly journals Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation

Blood ◽  
2016 ◽  
Vol 127 (5) ◽  
pp. 626-636 ◽  
Author(s):  
Brian Estevez ◽  
Kyungho Kim ◽  
M. Keegan Delaney ◽  
Aleksandra Stojanovic-Terpo ◽  
Bo Shen ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Platelet Activation ◽  
Cytoplasmic Domain ◽  
Platelet Response ◽  
Protease Activated Receptors ◽  
Glycoprotein Ib ◽  
Low Concentrations ◽  
Key Points ◽  
Specific Signaling Pathway

Key Points GPIb-IX signaling cooperates with PAR signaling to promote platelet response to low concentrations of thrombin, which are important in vivo. Thrombin induces a GPIb-IX–specific signaling pathway that requires the cytoplasmic domain of GPIbα, 14-3-3 protein, Rac1, and LIMK1.

scholarly journals SignaFish: a zebrafish-specific signaling pathway resource

2016 ◽  
Author(s):  
Kitti Csályi ◽  
Dávid Fazekas ◽  
Tamás Kadlecsik ◽  
Dénes Türei ◽  
Leila Gul ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Fruit Fly ◽  
Model Organisms ◽  
Signaling Networks ◽  
Cell Fates ◽  
Invertebrate Model ◽  
Signaling Interactions ◽  
Model Fish Species ◽  
Specific Signaling Pathway ◽  
Model Fish

Understanding living systems requires an in depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication and contribute to cell fates during development. Several resources exist to provide high-throughput datasets or manually curated interaction information from human or invertebrate model organisms. We previously developed SignaLink, a uniformly curated, multi-layered signaling resource containing information for human and for the model organisms nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster. Until now, the use of the SignaLink database for zebrafish pathway analysis was limited. To overcome this limitation we created SignaFish (http://signafish.org), a fish-specific signaling resource, built using the concept of SignaLink. SignaFish contains more than 200 curation based signaling interactions, 132 further interactions listed in other resources, and it also lists potential miRNA based regulatory connections for 7 major signaling pathways. From the SignaFish website, users can reach other web resources, such as ZFIN. SignaFish provides signaling or signaling-related interactions that can be examined for each gene, or downloaded for each signaling pathway. We believe that the SignaFish resource will serve as a novel navigating point for experimental design and evaluation for the zebrafish community and for researchers focusing on non-model fish species, such as cyclids.

scholarly journals Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors

2001 ◽  
Vol 276 (25) ◽  
pp. 22685-22698 ◽  
Author(s):  
Colleen Sweeney ◽  
Douglas Fambrough ◽  
Christine Huard ◽  
A. John Diamonti ◽  
Eric S. Lander ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Erbb Receptors ◽  
Specific Signaling Pathway

scholarly journals Mesangial Cells and Glomerular Endothelial Cells Crosstalk in Rat Anti-Thy-1 Nephritis through VEGFA/VEGFAR2 and Angpt2/Tie2 pathway

2020 ◽  
Author(s):  
yinghua zhao ◽  
Bo Fu ◽  
Pu Chen ◽  
Qinggang Li ◽  
Qing Ouyang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Signaling Pathway ◽  
Mesangial Cells ◽  
Proliferative Glomerulonephritis ◽  
Mesangial Proliferative Glomerulonephritis ◽  
Surface Receptor ◽  
Mimic Peptide ◽  
Specific Signaling Pathway

Abstract BACKGROUNDMesangial proliferative glomerulonephritis is characterized by the proliferation of mesangial cells (MCs). Endothelial cells (ECs) are affected by signals from MCs, resulting in capillary proliferation, but the specific signaling pathway associated with this activity remains unclear.RESULTSIn this study, the expression of PCNA, RECA-1 and CD34 in the glomeruli increased on the 7th day after anti-Thy-1 nephritis establishment, indicating the occurrence of ECs proliferation. After coculturing MCs and ECs in vitro, we observed that activated MCs could promote ECs proliferation, migration and α-SMA expression. Moreover, activated ECs had the same effects on MCs. RT-qPCR showed that activated MCs could increasingly secrete VEGFA, and Angpt2 expression in VEGFA-activated ECs was enhanced. Considering that Angpt2-mediated inhibition of ECs surface receptor Tie2 phosphorylation causes ECs proliferation, we hypothesized that VEGFA/VEGFR2 and Angpt2/Tie2 signaling is involved in the interaction between MCs and ECs. Our results showed that blocking VEGFA or adding the Angpt2 antagonist Angpt1 to the coculture system decreased the number of EdU-positive cells，Angpt2，p-VEGFR2 and p-MAPK expression, but increased p-Tie2 in ECs. To determine whether Angpt1 could effectively alleviate the pathological changes of anti-Thy-1 nephritis, we performed Vasculotide (Angpt1 mimic peptide) treatment assays in vivo. The results confirmed that the addition of Vasculotide could effectively reduce PCNA, RECA-1 and α-SMA expression and promote p-Tie2.CONCLUSIONIn summary, the study showed that the VEGFA/VEGFR2 and Angpt2/Tie2 signaling pathway mediate interactions between MCs and ECs, providing an important theoretical basis for the treatment of mesangial proliferative glomerulonephritis.

scholarly journals RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

Oncogene ◽  
2012 ◽  
Vol 31 (45) ◽  
pp. 4740-4749 ◽  
Author(s):  
B Li ◽  
M A Antonyak ◽  
J Zhang ◽  
R A Cerione
Keyword(s):  
Cancer Cells ◽  
Signaling Pathway ◽  
Specific Signaling Pathway

scholarly journals Rapid Phosphorylation of a Syntaxin during the Avr9/Cf-9-Race-Specific Signaling Pathway

2005 ◽  
Vol 138 (4) ◽  
pp. 2406-2416 ◽  
Author(s):  
Antje Heese ◽  
Andrea A. Ludwig ◽  
Jonathan D.G. Jones
Keyword(s):  
Signaling Pathway ◽  
Specific Signaling Pathway
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