Use of Adjuvants to Enhance the Immune Response Induced by a DNA Vaccine Against Bovine Herpesvirus-1

2015 ◽  
Vol 28 (6) ◽  
pp. 343-346 ◽  
Author(s):  
Sebastián Di Giacomo ◽  
Valeria Quattrocchi ◽  
Patricia Zamorano
Keyword(s):  
Immune Response ◽  
Dna Vaccine ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

A combined bovine herpesvirus 1 gB-gD DNA vaccine induces immune response in mice

2005 ◽  
Vol 28 (2) ◽  
pp. 155-166 ◽  
Author(s):  
E CASELLI ◽  
M BONI ◽  
D DILUCA ◽  
D SALVATORI ◽  
A VITA ◽  
...  
Keyword(s):  
Immune Response ◽  
Dna Vaccine ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1

Virology ◽  
2021 ◽  
Author(s):  
Kornuta Claudia Alejandra ◽  
Cheuquepán Felipe ◽  
Bidart Juan Esteban ◽  
Soria Ivana ◽  
Gammella Mariela ◽  
...  
Keyword(s):  
Immune Response ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Commercial Vaccine ◽  
Herpesvirus 1

Induction of immune responses in cattle with a DNA vaccine encoding glycoprotein C of bovine herpesvirus-1

2001 ◽  
Vol 78 (4) ◽  
pp. 293-305 ◽  
Author(s):  
Praveen K. Gupta ◽  
Mohini Saini ◽  
L.K. Gupta ◽  
V.D.P. Rao ◽  
S.K. Bandyopadhyay ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Glycoprotein C ◽  
Herpesvirus 1

Intercellular trafficking of the major tegument protein VP22 of bovine herpesvirus-1 and its application to improve a DNA vaccine

2005 ◽  
Vol 151 (5) ◽  
pp. 985-993 ◽  
Author(s):  
C. F. Zheng ◽  
R. Brownlie ◽  
D. Y. Huang ◽  
L. A. Babiuk ◽  
S. van Drunen Littel-van den Hurk
Keyword(s):  
Dna Vaccine ◽  
Bovine Herpesvirus ◽  
Tegument Protein ◽  
Bovine Herpesvirus 1 ◽  
Intercellular Trafficking ◽  
Herpesvirus 1 ◽  
Protein Vp22

scholarly journals Immunity to Bovine Herpesvirus 1: I. Viral lifecycle and innate immunity

2013 ◽  
Vol 14 (1) ◽  
pp. 88-102 ◽  
Author(s):  
Randall L. Levings ◽  
James A. Roth
Keyword(s):  
Immune Response ◽  
Latent Infection ◽  
Bovine Herpesvirus ◽  
Lytic Replication ◽  
Host Cells ◽  
Type I Interferons ◽  
Disease Spread ◽  
Type I ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

AbstractBovine herpesvirus 1 (BHV-1) causes a variety of diseases and is globally distributed. It infects via mucosal epithelium, leading to rapid lytic replication and latent infection, primarily in sensory ganglia. Large amounts of virus can be excreted by the host on primary infection or upon recrudescence of latent infection, resulting in disease spread. The bovine immune response to BHV-1 is rapid, robust, balanced, and long-lasting. The innate immune system is the first to respond to the infection, with type I interferons (IFNs), inflammatory cytokines, killing of infected host cells, and priming of a balanced adaptive immune response. The virus possesses a variety of immune evasion strategies, including inhibition of type I IFN production, chemokine and complement binding, infection of macrophages and neutrophils, and latency. BHV-1 immune suppression contributes to the severity of its disease manifestations and to the bovine respiratory disease complex, the leading cause of cattle death loss in the USA.

Induction of Immune Response to Bovine Herpesvirus-1 with Anti-idiotypic Antibodies

1991 ◽  
Vol 4 (2) ◽  
pp. 111-122 ◽  
Author(s):  
D.J. ORTEN ◽  
P.O. REDDY ◽  
D.N. REDDY ◽  
W. XUE ◽  
O.Y. ABDELMAGID ◽  
...  
Keyword(s):  
Immune Response ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

An Improved DNA Vaccine Against Bovine Herpesvirus-1 Using CD40L and a Chemical Adjuvant Induces Specific Cytotoxicity in Mice

2020 ◽  
Author(s):  
Cecilia A. Langellotti ◽  
Mariela Gammella ◽  
Ivana Soria ◽  
Carolina Bellusci ◽  
Valeria Quattrocchi ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Specific Cytotoxicity ◽  
Herpesvirus 1

Immunity to bovine herpesvirus 1: II. Adaptive immunity and vaccinology

2013 ◽  
Vol 14 (1) ◽  
pp. 103-123 ◽  
Author(s):  
Randall L. Levings ◽  
James A. Roth
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Cytotoxic T Lymphocyte ◽  
Clinical Signs ◽  
Human Herpesvirus ◽  
Bovine Herpesvirus ◽  
Genetically Engineered ◽  
Cell Mediated Immunity ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

AbstractBovine herpesvirus 1 (BHV-1) infection is widespread and causes a variety of diseases. Although similar in many respects to the human immune response to human herpesvirus 1, the differences in the bovine virus proteins, immune system components and strategies, physiology, and lifestyle mean the bovine immune response to BHV-1 is unique. The innate immune system initially responds to infection, and primes a balanced adaptive immune response. Cell-mediated immunity, including cytotoxic T lymphocyte killing of infected cells, is critical to recovery from infection. Humoral immunity, including neutralizing antibody and antibody-dependent cell-mediated cytotoxicity, is important to prevention or control of (re-)infection. BHV-1 immune evasion strategies include suppression of major histocompatibility complex presentation of viral antigen, helper T-cell killing, and latency. Immune suppression caused by the virus potentiates secondary infections and contributes to the costly bovine respiratory disease complex. Vaccination against BHV-1 is widely practiced. The many vaccines reported include replicating and non-replicating, conventional and genetically engineered, as well as marker and non-marker preparations. Current development focuses on delivery of major BHV-1 glycoproteins to elicit a balanced, protective immune response, while excluding serologic markers and virulence or other undesirable factors. In North America, vaccines are used to prevent or reduce clinical signs, whereas in some European Union countries marker vaccines have been employed in the eradication of BHV-1 disease.

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