Augmented Humoral and Cellular Immune Responses Induced by Canine Adenovirus Type 1 DNA Vaccine in BALB/c Mice

2007 ◽  
Vol 20 (3) ◽  
pp. 461-468 ◽  
Author(s):  
Jun-Xia Wang ◽  
Long Zheng ◽  
Shu-Xia Song ◽  
Xia Zhang ◽  
Li-Min Li ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Adenovirus Type ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals A polyvalent influenza DNA vaccine applied by needle-free intradermal delivery induces cross-reactive humoral and cellular immune responses in pigs

Vaccine ◽  
2016 ◽  
Vol 34 (32) ◽  
pp. 3634-3640 ◽  
Author(s):  
Marie Borggren ◽  
Jens Nielsen ◽  
Ingrid Karlsson ◽  
Tina S. Dalgaard ◽  
Ramona Trebbien ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Cellular Immune Responses ◽  
Intradermal Delivery ◽  
Cellular Immune

scholarly journals Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine

Vaccine ◽  
2008 ◽  
Vol 26 (49) ◽  
pp. 6225-6231 ◽  
Author(s):  
Krystle A. Lang ◽  
Jian Yan ◽  
Ruxandra Draghia-Akli ◽  
Amir Khan ◽  
David B. Weiner
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Rhesus Macaques ◽  
Hcv Genotype ◽  
Cellular Immune Responses ◽  
Genotype 1A ◽  
Cellular Immune

Augmented humoral and cellular immune responses of a hepatitis B DNA vaccine encoding HBsAg by protein boosting

Vaccine ◽  
2005 ◽  
Vol 23 (14) ◽  
pp. 1649-1656 ◽  
Author(s):  
He Xiao-wen ◽  
Sun Shu-han ◽  
Hu Zhen-lin ◽  
Li Jun ◽  
Jiang Lei ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Cellular Immune Responses of Schistosomiasis Patients Are Altered by Human Immunodeficiency Virus Type 1 Coinfection

2001 ◽  
Vol 184 (4) ◽  
pp. 488-496 ◽  
Author(s):  
Pauline N. M. Mwinzi ◽  
Diana M. S. Karanja ◽  
Daniel G. Colley ◽  
Alloys S. S. Orago ◽  
W. Evan Secor
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cellular Immune Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune

scholarly journals Human Immunodeficiency Virus Type 1-Hepatitis C Virus Coinfection: Intraindividual Comparison of Cellular Immune Responses against Two Persistent Viruses

2002 ◽  
Vol 76 (6) ◽  
pp. 2817-2826 ◽  
Author(s):  
Georg M. Lauer ◽  
Tam N. Nguyen ◽  
Cheryl L. Day ◽  
Gregory K. Robbins ◽  
Theresa Flynn ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
T Lymphocyte ◽  
Viral Loads ◽  
Cellular Immune Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune ◽  
Lymphocyte Responses ◽  
Hiv 1

ABSTRACT Both human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) lead to chronic infection in a high percentage of persons, and an expanding epidemic of HIV-1-HCV coinfection has recently been identified. These individuals provide an opportunity for simultaneous assessment of immune responses to two viral infections associated with chronic plasma viremia. In this study we analyzed the breadth and magnitude of the CD8+- and CD4+-T-lymphocyte responses in 22 individuals infected with both HIV-1 and HCV. A CD8+-T-lymphocyte response against HIV-1 was readily detected in all subjects over a broad range of viral loads. In marked contrast, HCV-specific CD8+-T-lymphocyte responses were rarely detected, despite viral loads in plasma that were on average 1,000-fold higher. The few HCV-specific responses that were observed were relatively weak and limited in breadth. CD4-proliferative responses against HIV-1 were detected in about half of the coinfected subjects tested, but no proliferative response against any HCV protein was found in these coinfected persons. These data demonstrate a major discordance in immune responses to two persistent RNA viruses. In addition, they show a consistent and profound impairment in cellular immune responses to HCV compared to HIV-1 in HIV-1-HCV-coinfected persons.

Antitumor Effect of a DNA Vaccine Harboring Prostate Cancer-Specific Antigen with IL-12 as an Intramolecular Adjuvant

2017 ◽  
Vol 27 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Yu Yang ◽  
Zhiqiang Shao ◽  
Jiangping Gao
Keyword(s):  
Prostate Cancer ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Dna Vaccines ◽  
Electric Pulse ◽  
Specific Antigen ◽  
Interleukin 12 ◽  
Cellular Immune Responses ◽  
Prostate Cancer Therapy ◽  
Cellular Immune

To improve the lower immune intensity of DNA vaccines, we developed a DNA vaccine based on prostate cancer-specific antigen (PSA), which has been suggested as a potential target for prostate cancer therapy, and enhanced the DNA vaccine potency using interleukin-12 (IL-12) as an intramolecular adjuvant. A series of DNA plasmids encoding human PSA, IL-12, and their conjugates was constructed and injected into female mice intramuscularly, followed by an electric pulse. The humoral and cellular immune responses after immunization were detected by ELISA and ELISPOT, respectively. To evaluate the therapeutic efficacy of these plasmids, a mouse model with a PSA-expressing tumor was constructed. Mice vaccinated with PSA-IL-12 plasmids elicited the strongest PSA-specific humoral and cellular immune responses. Furthermore, these vaccinations inhibited the growth of PSA-expressing tumors and prolonged mouse survival. These observations emphasize the potential of the IL-12 gene as an intramolecular adjuvant for DNA vaccines. Moreover, the vaccine based on PSA and IL-12 may be a promising treatment for prostate cancer.

The Humoral and Cellular Immune Responses in Mice Induced by DNA Vaccine Expressing the Sporozoite Surface Protein ofCryptosporidium parvum

2004 ◽  
Vol 23 (5) ◽  
pp. 335-339 ◽  
Author(s):  
Hongxuan He ◽  
Baohua Zhao ◽  
Liyan Liu ◽  
Kai Zhou ◽  
Ximing Qin ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Surface Protein ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine

2014 ◽  
Vol 10 (8) ◽  
pp. 2357-2365 ◽  
Author(s):  
Brian Latimer ◽  
Roberta Toporovski ◽  
Jian Yan ◽  
Panyupa Pankhong ◽  
Matthew P Morrow ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Rhesus Macaques ◽  
Hcv Genotype ◽  
Cellular Immune Responses ◽  
Genotype 1A ◽  
Cellular Immune

Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes

2003 ◽  
Vol 19 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Parth Narendran ◽  
Alistair J. Williams ◽  
Kathryn Elsegood ◽  
Nicola J. Leech ◽  
Colin M. Dayan
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Newly Diagnosed ◽  
Cellular Immune Responses ◽  
Cellular Immune
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