Needle-Free Jet Injection of a Mixture of Japanese Encephalitis DNA and Protein Vaccines: A Strategy to Effectively Enhance Immunogenicity of the DNA Vaccine in a Murine Model

2005 ◽  
Vol 18 (1) ◽  
pp. 205-212 ◽  
Author(s):  
Jun-Ichi Imoto ◽  
Eiji Konishi
Keyword(s):  
Dna Vaccine ◽  
Japanese Encephalitis ◽  
Murine Model ◽  
Jet Injection ◽  
Free Jet ◽  
Protein Vaccines

scholarly journals Integration of needle-free jet injection with advanced electroporation delivery enhances the magnitude, kinetics, and persistence of engineered DNA vaccine induced immune responses

Vaccine ◽  
2019 ◽  
Vol 37 (29) ◽  
pp. 3832-3839 ◽  
Author(s):  
Jingjing Jiang ◽  
Stephanie J. Ramos ◽  
Preeti Bangalore ◽  
Paul Fisher ◽  
Kristine Germar ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Jet Injection ◽  
Free Jet

scholarly journals Protective efficacy of a SARS-CoV-2 DNA vaccine in wild-type and immunosuppressed Syrian hamsters

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Rebecca L. Brocato ◽  
Steven A. Kwilas ◽  
Robert K. Kim ◽  
Xiankun Zeng ◽  
Lucia M. Principe ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Neutralizing Antibodies ◽  
Protective Efficacy ◽  
Phase 1 ◽  
Severe Disease ◽  
Disease Model ◽  
Wild Type ◽  
Jet Injection ◽  
Syrian Hamsters ◽  
Dna Targeting

AbstractA worldwide effort to counter the COVID-19 pandemic has resulted in hundreds of candidate vaccines moving through various stages of research and development, including several vaccines in phase 1, 2 and 3 clinical trials. A relatively small number of these vaccines have been evaluated in SARS-CoV-2 disease models, and fewer in a severe disease model. Here, a SARS-CoV-2 DNA targeting the spike protein and delivered by jet injection, nCoV-S(JET), elicited neutralizing antibodies in hamsters and was protective in both wild-type and transiently immunosuppressed hamster models. This study highlights the DNA vaccine, nCoV-S(JET), we developed has a great potential to move to next stage of preclinical studies, and it also demonstrates that the transiently-immunosuppressed Syrian hamsters, which recapitulate severe and prolonged COVID-19 disease, can be used for preclinical evaluation of the protective efficacy of spike-based COVID-19 vaccines.

Needle-Free Jet Injection for Vaccine Administration

Vaccinology ◽  
2012 ◽  
pp. 324-335 ◽  
Author(s):  
Brian R. Sloat ◽  
Hoi K. Tran ◽  
Zhengrong Cui
Keyword(s):  
Jet Injection ◽  
Vaccine Administration ◽  
Free Jet

Development of an effective Japanese encephalitis virus-specific DNA vaccine

2006 ◽  
Vol 8 (11) ◽  
pp. 2578-2586 ◽  
Author(s):  
Chang Jer Wu ◽  
Tsung Lin Li ◽  
Hui Wen Huang ◽  
Mi Hua Tao ◽  
Yi Lin Chan
Keyword(s):  
Japanese Encephalitis Virus ◽  
Dna Vaccine ◽  
Japanese Encephalitis ◽  
Encephalitis Virus
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