scholarly journals Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: Increased t allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

2005 ◽  
Vol 52 (8) ◽  
pp. 2396-2402 ◽  
Author(s):  
Hui Wu ◽  
Rita M. Cantor ◽  
Deborah S. Cunninghame Graham ◽  
Cecilia M. Lingren ◽  
Lisa Farwell ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Allele Frequency ◽  
Association Analysis ◽  
Protein Tyrosine Phosphatase ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Tyrosine Phosphatase ◽  
Systemic Lupus ◽  
Autoimmune Thyroid

R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity

2013 ◽  
Vol 25 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Rasha Tarif Hamza ◽  
Khaled S. Awwad ◽  
Khaled A. Temsah ◽  
Amira I. Hamed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Protein Tyrosine Phosphatase ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Tyrosine Phosphatase ◽  
Systemic Lupus ◽  
Protein Tyrosine ◽  
Autoimmune Thyroid

Abstract Background: Some studies showed associations of the minor T allele of the C1858T single nucleotide polymorphism (SNP) corresponding to the R620W amino acid substitution of protein tyrosine phosphatase (PTPN22) with multiple autoimmune diseases, including systemic lupus erythematosus (SLE). Objectives: To study the frequency of PTPN22 R620W polymorphism among Egyptian patients with SLE and to test the association of the T allele with autoimmune thyroid disease in such patients. Methods: Clinical evaluation, measurement of thyroid hormones and antibodies, and genotyping of PTPN22 R620W polymorphism were done for 60 SLE patients and 60 age- and sex-matched healthy subjects. Results: Nineteen SLE cases (31.67%) had thyroid dysfunction with subclinical hypothyroidism being the most frequent form of thyroid dysfunction (20%) followed by primary hypothyroidism (6.67%), subclinical hyperthyroidism (3.33%) and primary hyperthyroidism (1.67%). Autoimmune thyroid disease was detected in 36.67% of cases. Systemic lupus erythematosus disease activity index (SLEDAI) score did not differ between patients with thyroid dysfunction and euthyroid patients (p=0.061) nor with the frequency of positive thyroid peroxidise antibodies (TPOAb, p=0.092) and antithyroglobulin antibodies (ATGAb, p=0.1). T allele frequency did not differ between cases and controls (p=1.19) and was associated with autoimmune thyroid disease in Egyptian SLE patients (p=0.002). Conclusions: R620W polymorphism of the PTPN22 gene is not a major risk allele for SLE susceptibility among Egyptian SLE patients but appears to be a risk factor for concurrent autoimmune thyroid disease and SLE.

scholarly journals Autoimmune thyroid disease and associated rheumatic disorders

2005 ◽  
Vol 133 (Suppl. 1) ◽  
pp. 55-60 ◽  
Author(s):  
Djunajdar Kerimovic-Morina
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Systemic Lupus ◽  
Autoimmune Thyroid ◽  
Antithyroid Antibodies

Musculosceletal manifestations were found in patients with hyperthyroidism as well as hypothyroidism. This article will review the available evidence that autoimmune thyroid disease is associated with: Sj?gren?s sydrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis, rheumatoid arthritis (RA) and spondyloarthropathies. Possible pathogenesis of these manifestations has not been completely established. Sj?gren?s syndrome occurs in about 1/10 of patients with autoimmune thyroid disease; patients with SLE and antithyroid antibodies were significantly older than those pattiens without antibodies. Patients with systemic sclerosis and thyroid disease were significantly younger than those without antibodies. Thyroid disfunction was found three times more often in women with RA than in women with noninflammatory rheumatic diseases, and those with thyroid disease tended to have a shorter duration of arthritis.

scholarly journals Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease

2005 ◽  
Vol 52 (11) ◽  
pp. 3646-3650 ◽  
Author(s):  
Bahram Namjou ◽  
Jennifer A. Kelly ◽  
Jeff Kilpatrick ◽  
Kenneth M. Kaufman ◽  
Swapan K. Nath ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Systemic Lupus ◽  
Autoimmune Thyroid

Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus

2014 ◽  
Vol 83 (6) ◽  
pp. 943-950 ◽  
Author(s):  
Juan-Sebastian Franco ◽  
Jenny Amaya-Amaya ◽  
Nicolás Molano-González ◽  
Julian Caro-Moreno ◽  
Mónica Rodríguez-Jiménez ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Systemic Lupus ◽  
Autoimmune Thyroid
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