scholarly journals Epigenetic Modulators Enhance Constitutive and Liver-Specific Reporter Expression in Murine Liver Progenitor Cell Lines

2015 ◽  
Vol 21 (10) ◽  
pp. 1080-1087 ◽  
Author(s):  
Luke Aris Diepeveen ◽  
Michel Elyse Watson ◽  
Sarah Beth McSpadden ◽  
Robyn Patricia Strauss ◽  
Bernard Andrew Callus ◽  
...  
Keyword(s):  
Cell Lines ◽  
Progenitor Cell ◽  
Reporter Expression ◽  
Murine Liver ◽  
Liver Progenitor Cell

scholarly journals Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

Hepatology ◽  
2015 ◽  
Vol 62 (4) ◽  
pp. 1272-1284 ◽  
Author(s):  
Caryn L. Elsegood ◽  
Chun Wei Chan ◽  
Mariapia A. Degli-Esposti ◽  
Matthew E. Wikstrom ◽  
Alice Domenichini ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Kupffer Cell ◽  
Progenitor Cell ◽  
Murine Liver ◽  
Liver Progenitor Cell

scholarly journals Human Liver Progenitor Cell Lines Are Readily Established From Non-Tumorous Tissue Adjacent to Hepatocellular Carcinoma

2010 ◽  
Vol 19 (8) ◽  
pp. 1277-1284 ◽  
Author(s):  
Aibin Zhang ◽  
Roslyn London ◽  
Frederik Michael Schulz ◽  
Philippe Wilfred Roger Giguère-Simmonds ◽  
Luc Delriviere ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Human Liver ◽  
Progenitor Cell ◽  
Liver Progenitor Cell

scholarly journals Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 523
Author(s):  
Abhirup Bagchi ◽  
Aneesha Nath ◽  
Vasanth Thamodaran ◽  
Smitha Ijee ◽  
Dhavapriya Palani ◽  
...  
Keyword(s):  
Cell Lines ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Progenitor Cell ◽  
Mononuclear Cells ◽  
Red Cell ◽  
Peripheral Blood Mononuclear ◽  
Erythroid Progenitor ◽  
Erythroid Progenitor Cell ◽  
Blood Mononuclear Cells

Reliable human erythroid progenitor cell (EPC) lines that can differentiate to the later stages of erythropoiesis are important cellular models for studying molecular mechanisms of human erythropoiesis in normal and pathological conditions. Two immortalized erythroid progenitor cells (iEPCs), HUDEP-2 and BEL-A, generated from CD34+ hematopoietic progenitors by the doxycycline (dox) inducible expression of human papillomavirus E6 and E7 (HEE) genes, are currently being used extensively to study transcriptional regulation of human erythropoiesis and identify novel therapeutic targets for red cell diseases. However, the generation of iEPCs from patients with red cell diseases is challenging as obtaining a sufficient number of CD34+ cells require bone marrow aspiration or their mobilization to peripheral blood using drugs. This study established a protocol for culturing early-stage EPCs from peripheral blood (PB) and their immortalization by expressing HEE genes. We generated two iEPCs, PBiEPC-1 and PBiEPC-2, from the peripheral blood mononuclear cells (PBMNCs) of two healthy donors. These cell lines showed stable doubling times with the properties of erythroid progenitors. PBiEPC-1 showed robust terminal differentiation with high enucleation efficiency, and it could be successfully gene manipulated by gene knockdown and knockout strategies with high efficiencies without affecting its differentiation. This protocol is suitable for generating a bank of iEPCs from patients with rare red cell genetic disorders for studying disease mechanisms and drug discovery.

scholarly journals Establishment of Human Trophoblast Progenitor Cell Lines from the Chorion

Stem Cells ◽  
2011 ◽  
pp. N/A-N/A ◽  
Author(s):  
Olga Genbacev ◽  
Matthew Donne ◽  
Mirhan Kapidzic ◽  
Matthew Gormley ◽  
Julie Lamb ◽  
...  
Keyword(s):  
Cell Lines ◽  
Progenitor Cell ◽  
Human Trophoblast

Adaptive remodeling of the biliary tree: the essence of liver progenitor cell expansion

2015 ◽  
Vol 22 (7) ◽  
pp. 546-550 ◽  
Author(s):  
Cindy Yuet-Yin Kok ◽  
Atsushi Miyajima ◽  
Tohru Itoh
Keyword(s):  
Cell Expansion ◽  
Progenitor Cell ◽  
Biliary Tree ◽  
Liver Progenitor Cell

scholarly journals Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish

2018 ◽  
Vol 18 (3) ◽  
pp. 157-170 ◽  
Author(s):  
Mehwish Khaliq ◽  
Sungjin Ko ◽  
Yinzi Liu ◽  
Hualin Wang ◽  
Yonghua Sun ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cell ◽  
Liver Progenitor Cell
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